{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T02:42:39Z","timestamp":1784169759631,"version":"3.55.0"},"reference-count":206,"publisher":"SAGE Publications","issue":"1-3","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Antioxidants &amp; Redox Signaling"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:sec>\n                    <jats:title>Significance:<\/jats:title>\n                    <jats:p>\n                      Hydrogen sulfide (H\n                      <jats:sub>2<\/jats:sub>\n                      S) is a recently recognized gasotransmitter involved in physiological and pathological conditions in mammals. It protects organs from oxidative stress, inflammation, hypertension, and cell death. With abundant expression of H\n                      <jats:sub>2<\/jats:sub>\n                      S-production enzymes, the liver is closely linked to H\n                      <jats:sub>2<\/jats:sub>\n                      S signaling.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Recent Advances:<\/jats:title>\n                    <jats:p>\n                      Hepatic H\n                      <jats:sub>2<\/jats:sub>\n                      S comes from various sources, including gut microbiota, exogenous sulfur salts, and endogenous production. Recent studies highlight the importance of hepatic H\n                      <jats:sub>2<\/jats:sub>\n                      S in liver diseases such as nonalcoholic fatty liver disease (NAFLD), liver injury, and cancer, particularly at advanced stages. Endogenous H\n                      <jats:sub>2<\/jats:sub>\n                      S production deficiency is associated with severe liver disease, while exogenous H\n                      <jats:sub>2<\/jats:sub>\n                      S donors protect against liver dysfunction.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Critical Issues:<\/jats:title>\n                    <jats:p>\n                      However, the roles of H\n                      <jats:sub>2<\/jats:sub>\n                      S in NAFLD, liver injury, and liver cancer are still debated, and its effects depend on donor type, dosage, treatment duration, and cell type, suggesting a multifaceted role. This review aimed to critically evaluate H\n                      <jats:sub>2<\/jats:sub>\n                      S production, metabolism, mode of action, and roles in liver function and disease.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Future Direction:<\/jats:title>\n                    <jats:p>\n                      Understanding H\n                      <jats:sub>2<\/jats:sub>\n                      S's precise roles and mechanisms in liver health will advance potential therapeutic applications in preclinical and clinical research. Targeting H\n                      <jats:sub>2<\/jats:sub>\n                      S-producing enzymes and exogenous H\n                      <jats:sub>2<\/jats:sub>\n                      S sources, alone or in combination with other drugs, could be explored. Quantifying endogenous H\n                      <jats:sub>2<\/jats:sub>\n                      S levels may aid in diagnosing and managing liver diseases.\n                      <jats:italic toggle=\"yes\">Antioxid. Redox Signal.<\/jats:italic>\n                      40, 122\u2013144.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/ars.2023.0404","type":"journal-article","created":{"date-parts":[[2023,11,2]],"date-time":"2023-11-02T11:33:33Z","timestamp":1698924813000},"page":"122-144","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":26,"title":["Hydrogen Sulfide and Liver Health: Insights into Liver Diseases"],"prefix":"10.1177","volume":"40","author":[{"given":"Thuy T.P.","family":"Nguyen","sequence":"first","affiliation":[{"name":"Department of Animal Science, College of Agriculture and Life Science, Chonnam National University, Gwangju, Republic of Korea."},{"name":"Division of Radiation and Genome Stability, Department of Radiation Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phuc 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