{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T04:04:30Z","timestamp":1777435470166,"version":"3.51.4"},"reference-count":194,"publisher":"SAGE Publications","issue":"7-9","license":[{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Antioxidants &amp; Redox Signaling"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:sec>\n                    <jats:title>Significance:<\/jats:title>\n                    <jats:p>\n                      Musculoskeletal diseases seriously affect global health, but their importance is greatly underestimated. These diseases often afflict the elderly, leading to disability, paralysis, and other complications. Hydrogen sulfide (H\n                      <jats:sub>2<\/jats:sub>\n                      S) plays an important role in the occurrence and development of musculoskeletal diseases, which may have potential therapeutic significance for these diseases.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Recent Advances:<\/jats:title>\n                    <jats:p>\n                      Recently, it has been found that many musculoskeletal diseases, such as osteoporosis, periodontitis, muscle atrophy, muscle ischemia\u2013reperfusion injury, muscle contraction under high fever, arthritis, and disc herniation, can be alleviated by treatment with H\n                      <jats:sub>2<\/jats:sub>\n                      S. H\n                      <jats:sub>2<\/jats:sub>\n                      S may be conducive to the development of multiple myeloma. The mechanism of action of H\n                      <jats:sub>2<\/jats:sub>\n                      S in the musculoskeletal system has been partly elucidated. A variety of H\n                      <jats:sub>2<\/jats:sub>\n                      S donors and nano-delivery systems provide promising prospects for H\n                      <jats:sub>2<\/jats:sub>\n                      S-based therapies.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Critical Issues:<\/jats:title>\n                    <jats:p>\n                      Related research remains at the level of cell or animal experiments, but clinical research is lacking. The roles of H\n                      <jats:sub>2<\/jats:sub>\n                      S in more musculoskeletal disorders remain largely unknown. The serious consequences of musculoskeletal diseases have not been widely concerned. Targeted delivery of H\n                      <jats:sub>2<\/jats:sub>\n                      S remains a challenging task in musculoskeletal diseases.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Future Directions:<\/jats:title>\n                    <jats:p>\n                      Develop therapeutic drugs for musculoskeletal diseases based on H\n                      <jats:sub>2<\/jats:sub>\n                      S and test their safety, efficacy, and tolerance. Explore the combination of current drugs for musculoskeletal diseases with H\n                      <jats:sub>2<\/jats:sub>\n                      S-releasing components to improve the therapeutic efficacy and avoid side effects. Carry out relevant clinical trials to verify the possibility of its widespread use.\n                      <jats:italic toggle=\"yes\">Antioxid. Redox Signal.<\/jats:italic>\n                      42, 321\u2013340.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/ars.2024.0625","type":"journal-article","created":{"date-parts":[[2024,9,14]],"date-time":"2024-09-14T09:22:56Z","timestamp":1726305776000},"page":"321-340","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Hydrogen Sulfide in Musculoskeletal Diseases: Molecular Mechanisms and Therapeutic Opportunities"],"prefix":"10.1177","volume":"42","author":[{"given":"Ya-Fang","family":"Liu","sequence":"first","affiliation":[{"name":"Henan International Joint Laboratory for Nuclear Protein Regulation, School of Basic Medical Sciences, School of Stomatology, Henan University, Kaifeng, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan-Xia","family":"Zhang","sequence":"additional","affiliation":[{"name":"Henan International Joint Laboratory for 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