{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T04:04:53Z","timestamp":1777435493298,"version":"3.51.4"},"reference-count":55,"publisher":"SAGE Publications","issue":"7-9","license":[{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Antioxidants &amp; Redox Signaling"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:sec>\n                    <jats:title>Aims:<\/jats:title>\n                    <jats:p>\n                      To investigate the role of the RegSR-NifA regulatory cascade in the oxygen control of nitric oxide (NO) reduction in the soybean endosymbiont\n                      <jats:italic toggle=\"yes\">Bradyrhizobium diazoefficiens<\/jats:italic>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      We have performed an integrated study of\n                      <jats:italic toggle=\"yes\">norCBQD<\/jats:italic>\n                      expression and NO reductase activity in\n                      <jats:italic toggle=\"yes\">regR<\/jats:italic>\n                      ,\n                      <jats:italic toggle=\"yes\">regS<\/jats:italic>\n                      <jats:sub>1<\/jats:sub>\n                      ,\n                      <jats:italic toggle=\"yes\">regS<\/jats:italic>\n                      <jats:sub>2<\/jats:sub>\n                      ,\n                      <jats:italic toggle=\"yes\">regS<\/jats:italic>\n                      <jats:sub>1\/2<\/jats:sub>\n                      , and\n                      <jats:italic toggle=\"yes\">nifA<\/jats:italic>\n                      mutants in response to microoxia (2% O\n                      <jats:sub>2<\/jats:sub>\n                      ) or anoxia. An activating role of RegR and NifA was observed under anoxia. In contrast, under microaerobic conditions, RegR acts as a repressor by binding to a RegR box located between the \u221210 and \u221235 regions within the\n                      <jats:italic toggle=\"yes\">norCBQD<\/jats:italic>\n                      promoter. In addition, both RegS\n                      <jats:sub>1<\/jats:sub>\n                      and RegS\n                      <jats:sub>2<\/jats:sub>\n                      sensors cooperated with RegR in repressing\n                      <jats:italic toggle=\"yes\">norCBQD<\/jats:italic>\n                      genes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Innovation:<\/jats:title>\n                    <jats:p>NO is a reactive gas that, at high levels, acts as a potent inhibitor of symbiotic nitrogen fixation. In this paper, we report new insights into the regulation of NO reductase, the major enzyme involved in NO removal in rhizobia. This knowledge will be crucial for the development of new strategies and management practices in agriculture, in particular, for improving legume production.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>\n                      Our results demonstrate, for the first time, a dual control of the RegSR two-component regulatory system on\n                      <jats:italic toggle=\"yes\">norCBQD<\/jats:italic>\n                      genes control in response to oxygen levels.\n                      <jats:italic toggle=\"yes\">Antioxid. Redox Signal.<\/jats:italic>\n                      42, 408\u2013420.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/ars.2024.0710","type":"journal-article","created":{"date-parts":[[2025,1,27]],"date-time":"2025-01-27T06:49:21Z","timestamp":1737960561000},"page":"408-420","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Dual Oxygen-Responsive Control by RegSR of Nitric Oxide Reduction in the Soybean Endosymbiont\n                    <i>Bradyrhizobium diazoefficiens<\/i>"],"prefix":"10.1177","volume":"42","author":[{"given":"Andrea","family":"Jim\u00e9nez-Leiva","sequence":"first","affiliation":[{"name":"Department of Soil and Plant Microbiology, Estaci\u00f3n Experimental del Zaid\u00edn, CSIC, Granada, Spain."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raquel A.","family":"Ju\u00e1rez-Martos","sequence":"additional","affiliation":[{"name":"Department of Soil and Plant Microbiology, Estaci\u00f3n Experimental del Zaid\u00edn, CSIC, Granada, Spain."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan J.","family":"Cabrera","sequence":"additional","affiliation":[{"name":"Department of Soil and Plant Microbiology, Estaci\u00f3n Experimental del Zaid\u00edn, CSIC, Granada, Spain."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda J.","family":"Torres","sequence":"additional","affiliation":[{"name":"Department of Soil and Plant Microbiology, Estaci\u00f3n Experimental del Zaid\u00edn, CSIC, Granada, Spain."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Socorro","family":"Mesa","sequence":"additional","affiliation":[{"name":"Department of Soil and Plant Microbiology, Estaci\u00f3n Experimental del Zaid\u00edn, CSIC, Granada, Spain."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2410-9484","authenticated-orcid":false,"given":"Mar\u00eda J.","family":"Delgado","sequence":"additional","affiliation":[{"name":"Department of Soil and Plant Microbiology, Estaci\u00f3n Experimental del Zaid\u00edn, CSIC, Granada, Spain."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,3,7]]},"reference":[{"key":"e_1_3_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mib.2023.102399"},{"key":"e_1_3_6_3_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.1996.438968.x"},{"key":"e_1_3_6_4_1","doi-asserted-by":"publisher","DOI":"10.1128\/jb.177.7.1760-1765.1995"},{"key":"e_1_3_6_5_1","doi-asserted-by":"publisher","DOI":"10.1128\/JB.180.15.3853-3863.1998"},{"key":"e_1_3_6_6_1","doi-asserted-by":"crossref","unstructured":"Bedmar EJ Bueno E Correa D et al. 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