{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T03:35:13Z","timestamp":1789616113318,"version":"build-2803163510"},"reference-count":199,"publisher":"SAGE Publications","issue":"16-18","license":[{"start":{"date-parts":[[2025,5,28]],"date-time":"2025-05-28T00:00:00Z","timestamp":1748390400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Antioxidants &amp; Redox Signaling"],"published-print":{"date-parts":[[2025,12,1]]},"abstract":"<jats:sec>\n                    <jats:title>Significance:<\/jats:title>\n                    <jats:p>Endothelial cells (ECs) are specialized cells lining the interior surface of blood vessels, playing a crucial role in vascular biology. They exhibit remarkable versatility, adapting to various tissue requirements. Their ability to respond to physiological and pathological stimuli ensures proper tissue function and homeostasis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Recent Advances:<\/jats:title>\n                    <jats:p>Hypoxia is when the oxygen level in a given organ, tissue, or cell type drops below the physiological level and is insufficient to maintain adequate homeostasis. ECs respond to hypoxia by activating various mechanisms. Hypoxia-induced changes in ECs can promote survival in low-oxygen environments by altering cellular metabolism and inducing neoangiogenesis. However, hypoxia-induced EC responses can also be detrimental, leading to increased production of reactive oxygen species, heightened inflammation, changes in vascular tone, increased permeability of the endothelial barrier, and a higher risk of coagulation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Critical Issues:<\/jats:title>\n                    <jats:p>\n                      Hypoxia-induced EC responses contribute to the pathogenesis of various diseases, including metabolic diseases (\n                      <jats:italic toggle=\"yes\">e.g.<\/jats:italic>\n                      , diabetes, chronic kidney disease), infectious diseases, chronic inflammation, neoplastic diseases, cardiovascular diseases (\n                      <jats:italic toggle=\"yes\">e.g.<\/jats:italic>\n                      , atherosclerosis, myocardial infarction, and stroke) lung diseases (\n                      <jats:italic toggle=\"yes\">e.g.<\/jats:italic>\n                      , chronic obstructive pulmonary disease and pulmonary hypertension), eye diseases (age-related macular degeneration and retinopathy), and neurodegenerative diseases (\n                      <jats:italic toggle=\"yes\">e.g.<\/jats:italic>\n                      , Alzheimer\u2019s disease and Parkinson\u2019s disease).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Future Directions:<\/jats:title>\n                    <jats:p>\n                      Detailed, disease-specific investigations are essential to delineate how endothelial hypoxia responses contribute to various pathologies. Understanding these mechanisms could reveal whether targeting endothelial hypoxia holds therapeutic potential.\n                      <jats:italic toggle=\"yes\">Antioxid. Redox Signal.<\/jats:italic>\n                      43, 849\u2013868.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/ars.2025.1022","type":"journal-article","created":{"date-parts":[[2025,5,28]],"date-time":"2025-05-28T12:55:38Z","timestamp":1748436938000},"page":"849-868","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":13,"title":["Hypoxia-Induced Changes in Endothelial Cell Phenotype and Function"],"prefix":"10.1177","volume":"43","author":[{"given":"Andrea","family":"T\u00f3th","sequence":"first","affiliation":[{"name":"MTA-DE Lend\u00fclet Vascular Pathophysiology Research Group, Research Centre for Molecular Medicine, Faculty of Medicine, University of Debrecen, Debrecen, Hungary."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4942-7091","authenticated-orcid":false,"given":"Vikt\u00f3ria","family":"Jeney","sequence":"additional","affiliation":[{"name":"MTA-DE Lend\u00fclet Vascular Pathophysiology Research Group, Research Centre for Molecular Medicine, Faculty of Medicine, University of Debrecen, Debrecen, Hungary."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,5,28]]},"reference":[{"key":"e_1_3_2_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2015.05.042"},{"key":"e_1_3_2_3_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00258.2016"},{"key":"e_1_3_2_4_1","doi-asserted-by":"publisher","DOI":"10.2119\/molmed.2011.00339"},{"key":"e_1_3_2_5_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a006429"},{"key":"e_1_3_2_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000255690.03436.ae"},{"key":"e_1_3_2_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.115.05886"},{"key":"e_1_3_2_8_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.202003-0719OC"},{"key":"e_1_3_2_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fchem.2020.592688"},{"key":"e_1_3_2_10_1","doi-asserted-by":"publisher","DOI":"10.1203\/pdr.0b013e318045beae"},{"key":"e_1_3_2_11_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1653708"},{"key":"e_1_3_2_12_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1993.264.5.C1102"},{"key":"e_1_3_2_13_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2012.237834"},{"key":"e_1_3_2_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2005.02.001"},{"key":"e_1_3_2_15_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.119.312509"},{"key":"e_1_3_2_16_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201802650RR"},{"key":"e_1_3_2_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-021-04379-z"},{"key":"e_1_3_2_18_1","doi-asserted-by":"publisher","DOI":"10.1159\/000181546"},{"key":"e_1_3_2_19_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI86387"},{"key":"e_1_3_2_20_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M611569200"},{"key":"e_1_3_2_21_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.01323"},{"key":"e_1_3_2_22_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.87.2.682"},{"key":"e_1_3_2_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/jth.12310"},{"key":"e_1_3_2_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1367"},{"key":"e_1_3_2_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/biof.1988"},{"key":"e_1_3_2_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2016.03.007"},{"key":"e_1_3_2_27_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-09-3541"},{"key":"e_1_3_2_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2016.10.006"},{"key":"e_1_3_2_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature04478"},{"key":"e_1_3_2_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1582-4934.2011.01258.x"},{"key":"e_1_3_2_31_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14092291"},{"key":"e_1_3_2_32_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2015.6329"},{"key":"e_1_3_2_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2009.08.015"},{"key":"e_1_3_2_34_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M001914200"},{"key":"e_1_3_2_35_1","doi-asserted-by":"publisher","DOI":"10.2147\/NSS.S442186"},{"key":"e_1_3_2_36_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2318904121"},{"key":"e_1_3_2_37_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2009.2861"},{"key":"e_1_3_2_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2020.11.006"},{"key":"e_1_3_2_39_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1912409116"},{"key":"e_1_3_2_40_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0232072"},{"key":"e_1_3_2_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2006.09.003"},{"key":"e_1_3_2_42_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.111.030775"},{"key":"e_1_3_2_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mito.2007.02.011"},{"key":"e_1_3_2_44_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.1992.263.3.L325"},{"key":"e_1_3_2_45_1","doi-asserted-by":"publisher","DOI":"10.3389\/FCVM.2023.1168339\/FULL"},{"key":"e_1_3_2_46_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-61779-906-8_6"},{"key":"e_1_3_2_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0092-8674(00)81812-7"},{"key":"e_1_3_2_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.CMET.2013.08.001"},{"key":"e_1_3_2_49_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-64479-6"},{"key":"e_1_3_2_50_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-biochem-050410-100030"},{"key":"e_1_3_2_51_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.094060"},{"key":"e_1_3_2_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2024.02.005"},{"key":"e_1_3_2_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2014.06.012"},{"key":"e_1_3_2_54_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.116.302855"},{"key":"e_1_3_2_55_1","doi-asserted-by":"publisher","DOI":"10.1152\/PHYSREV.00001.2017"},{"key":"e_1_3_2_56_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.120.316851"},{"key":"e_1_3_2_57_1","doi-asserted-by":"publisher","DOI":"10.1096\/FJ.09-134882"},{"key":"e_1_3_2_58_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-09-671982"},{"key":"e_1_3_2_59_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms11853"},{"key":"e_1_3_2_60_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42255-019-0117-9"},{"key":"e_1_3_2_61_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.117.309249"},{"key":"e_1_3_2_62_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.067868"},{"key":"e_1_3_2_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mam.2008.08.006"},{"key":"e_1_3_2_64_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.602532"},{"key":"e_1_3_2_65_1","doi-asserted-by":"publisher","DOI":"10.1039\/c7ib00068e"},{"key":"e_1_3_2_66_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00092.2016"},{"key":"e_1_3_2_67_1","doi-asserted-by":"publisher","DOI":"10.1042\/CS20160812"},{"key":"e_1_3_2_68_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199507273330403"},{"key":"e_1_3_2_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2011.10.491"},{"key":"e_1_3_2_70_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.115.306301"},{"key":"e_1_3_2_71_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.1041570317"},{"key":"e_1_3_2_72_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2013.5403"},{"key":"e_1_3_2_73_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-023-04897-w"},{"key":"e_1_3_2_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2004.11.009"},{"key":"e_1_3_2_75_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature08945"},{"key":"e_1_3_2_76_1","doi-asserted-by":"publisher","DOI":"10.1002\/stem.316"},{"key":"e_1_3_2_77_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12013-012-9491-6"},{"key":"e_1_3_2_78_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23137012"},{"key":"e_1_3_2_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2024.01.028"},{"key":"e_1_3_2_80_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1999.79.4.1283"},{"key":"e_1_3_2_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2017.04.025"},{"key":"e_1_3_2_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(90)90327-n"},{"key":"e_1_3_2_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2006.08.026"},{"key":"e_1_3_2_84_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00758.2015"},{"key":"e_1_3_2_85_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.23.24.9361-9374.2003"},{"key":"e_1_3_2_86_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.84.24.9265"},{"key":"e_1_3_2_87_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1059817"},{"key":"e_1_3_2_88_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2018.00110"},{"key":"e_1_3_2_89_1","doi-asserted-by":"publisher","DOI":"10.1126\/SCIENCE.1059796"},{"key":"e_1_3_2_90_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom11070982"},{"key":"e_1_3_2_91_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.30.17771"},{"key":"e_1_3_2_92_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2023.05.011"},{"key":"e_1_3_2_93_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00395-016-0546-5"},{"key":"e_1_3_2_94_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.01.015"},{"key":"e_1_3_2_95_1","doi-asserted-by":"publisher","DOI":"10.2174\/1874467211104030176"},{"key":"e_1_3_2_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2017.01.012"},{"key":"e_1_3_2_97_1","doi-asserted-by":"publisher","DOI":"10.15252\/embj.201796436"},{"key":"e_1_3_2_98_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.111.300233"},{"key":"e_1_3_2_99_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2012.06.004"},{"key":"e_1_3_2_100_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa035655"},{"key":"e_1_3_2_101_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.116.306534"},{"key":"e_1_3_2_102_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.1041530308"},{"key":"e_1_3_2_103_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI115367"},{"key":"e_1_3_2_104_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00424-017-1935-9"},{"key":"e_1_3_2_105_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00068.2010"},{"key":"e_1_3_2_106_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0092-8674(00)81282-9"},{"key":"e_1_3_2_107_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2009.02.018"},{"key":"e_1_3_2_108_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.20955"},{"key":"e_1_3_2_109_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-020-0227-y"},{"key":"e_1_3_2_110_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41401-021-00647-y"},{"key":"e_1_3_2_111_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2016.04.194"},{"key":"e_1_3_2_112_1","doi-asserted-by":"publisher","DOI":"10.1146\/ANNUREV-PHYSIOL-020518-114731"},{"key":"e_1_3_2_113_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00011-021-01518-2"},{"key":"e_1_3_2_114_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.CMET.2019.08.011"},{"key":"e_1_3_2_115_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2019.01003"},{"key":"e_1_3_2_116_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI118332"},{"key":"e_1_3_2_117_1","doi-asserted-by":"publisher","DOI":"10.1038\/S41586-021-03392-8"},{"key":"e_1_3_2_118_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2017.05.005"},{"key":"e_1_3_2_119_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1992.263.2.C326"},{"key":"e_1_3_2_120_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.123.067579"},{"key":"e_1_3_2_121_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-022-01080-1"},{"key":"e_1_3_2_122_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.115.05578"},{"key":"e_1_3_2_123_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni1275"},{"key":"e_1_3_2_124_1","doi-asserted-by":"publisher","DOI":"10.1016\/0090-6980(86)90208-x"},{"key":"e_1_3_2_125_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00313.2013"},{"key":"e_1_3_2_126_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jproteome.2c00255"},{"key":"e_1_3_2_127_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.582239"},{"key":"e_1_3_2_128_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1994.267.5.H1921"},{"key":"e_1_3_2_129_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00318.2014"},{"key":"e_1_3_2_130_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cr.7290176"},{"key":"e_1_3_2_131_1","doi-asserted-by":"publisher","DOI":"10.1023\/a:1007042729486"},{"key":"e_1_3_2_132_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.107.148015"},{"key":"e_1_3_2_133_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.113.301359"},{"key":"e_1_3_2_134_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.578955"},{"key":"e_1_3_2_135_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M205934200"},{"key":"e_1_3_2_136_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2018.08.026"},{"key":"e_1_3_2_137_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10456-016-9527-4"},{"key":"e_1_3_2_138_1","doi-asserted-by":"publisher","DOI":"10.1023\/a:1009053411094"},{"key":"e_1_3_2_139_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1681.2006.04475.x"},{"key":"e_1_3_2_140_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI114540"},{"key":"e_1_3_2_141_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1992.262.3.C546"},{"key":"e_1_3_2_142_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00533.2008"},{"key":"e_1_3_2_143_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.01230.2006"},{"key":"e_1_3_2_144_1","doi-asserted-by":"publisher","DOI":"10.1086\/690206"},{"key":"e_1_3_2_145_1","doi-asserted-by":"publisher","DOI":"10.1007\/S00018-015-1928-9\/METRICS"},{"key":"e_1_3_2_146_1","doi-asserted-by":"publisher","DOI":"10.4070\/kcj.2010.40.12.651"},{"key":"e_1_3_2_147_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.atv.0000012262.76205.6a"},{"key":"e_1_3_2_148_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000145613.01188.0B"},{"key":"e_1_3_2_149_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00021.2018"},{"key":"e_1_3_2_150_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.1995.65052138.x"},{"key":"e_1_3_2_151_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom10121614"},{"key":"e_1_3_2_152_1","doi-asserted-by":"publisher","DOI":"10.1111\/joim.12016"},{"key":"e_1_3_2_153_1","doi-asserted-by":"publisher","DOI":"10.1002\/stem.295"},{"key":"e_1_3_2_154_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.17.11205"},{"key":"e_1_3_2_155_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2020.12.104"},{"key":"e_1_3_2_156_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02722949"},{"key":"e_1_3_2_157_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1804932115"},{"key":"e_1_3_2_158_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M113.521344"},{"key":"e_1_3_2_159_1","doi-asserted-by":"publisher","DOI":"10.1242\/jeb.201.8.1153"},{"key":"e_1_3_2_160_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.110.219238"},{"issue":"4","key":"e_1_3_2_161_1","first-page":"391","article-title":"Prostacyclin therapy for pulmonary arterial hypertension","volume":"37","author":"Ruan C-H","year":"2010","unstructured":"Ruan C-H, , Dixon RAF, , Willerson JT, et al. Prostacyclin therapy for pulmonary arterial hypertension. Texas Hear Inst J, 2010; 37(4):391\u2013399.","journal-title":"Texas Hear Inst J"},{"key":"e_1_3_2_162_1","doi-asserted-by":"publisher","DOI":"10.1002\/wsbm.1382"},{"key":"e_1_3_2_163_1","doi-asserted-by":"publisher","DOI":"10.1182\/BLOOD-2010-10-314427"},{"key":"e_1_3_2_164_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.109.205138"},{"key":"e_1_3_2_165_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0092-8674(01)00518-9"},{"key":"e_1_3_2_166_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.01.021"},{"key":"e_1_3_2_167_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2005.07.007"},{"key":"e_1_3_2_168_1","doi-asserted-by":"publisher","DOI":"10.1038\/359843a0"},{"key":"e_1_3_2_169_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.045344"},{"key":"e_1_3_2_170_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.EJPHAR.2017.09.042"},{"key":"e_1_3_2_171_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12026-015-8703-8"},{"key":"e_1_3_2_172_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2018.01.027"},{"key":"e_1_3_2_173_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2016.01.017"},{"key":"e_1_3_2_174_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.12.8039"},{"key":"e_1_3_2_175_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2022.06.015"},{"key":"e_1_3_2_176_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00430.2017"},{"key":"e_1_3_2_177_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00396.2018"},{"key":"e_1_3_2_178_1","doi-asserted-by":"publisher","DOI":"10.1042\/CS20040370"},{"key":"e_1_3_2_179_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.0000020682.73694.ab"},{"key":"e_1_3_2_180_1","doi-asserted-by":"publisher","DOI":"10.1254\/jphs.14046fp"},{"key":"e_1_3_2_181_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41581-022-00587-8"},{"key":"e_1_3_2_182_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.11.1.72"},{"key":"e_1_3_2_183_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stemcr.2017.07.001"},{"key":"e_1_3_2_184_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1997.272.5.C1700"},{"key":"e_1_3_2_185_1","doi-asserted-by":"publisher","DOI":"10.1002\/stem.1048"},{"key":"e_1_3_2_186_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2008.02.044"},{"key":"e_1_3_2_187_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2021.102675"},{"key":"e_1_3_2_188_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000178991.71605.18"},{"key":"e_1_3_2_189_1","doi-asserted-by":"publisher","DOI":"10.1073\/PNAS.92.12.5510"},{"key":"e_1_3_2_190_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2002.037994"},{"key":"e_1_3_2_191_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2012.10.020"},{"key":"e_1_3_2_192_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0891-5849(00)00353-1"},{"key":"e_1_3_2_193_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.115.306841"},{"issue":"12","key":"e_1_3_2_194_1","first-page":"871","article-title":"Secretion of extracellular superoxide dismutase from muscle transduced with recombinant adenovirus inhibits the growth of B16 melanomas in mice","volume":"1","author":"Wheeler MD","year":"2003","unstructured":"Wheeler MD, , Smutney OM, , Samulski RJ. Secretion of extracellular superoxide dismutase from muscle transduced with recombinant adenovirus inhibits the growth of B16 melanomas in mice. Mol Cancer Res, 2003; 1(12):871\u2013881.","journal-title":"Mol Cancer Res"},{"key":"e_1_3_2_195_1","doi-asserted-by":"publisher","DOI":"10.15252\/emmm.201404511"},{"key":"e_1_3_2_196_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.110.216184"},{"key":"e_1_3_2_197_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-018-1291-5"},{"key":"e_1_3_2_198_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2023.11.008"},{"key":"e_1_3_2_199_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2010.06.005"},{"key":"e_1_3_2_200_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2613.2006.00503.x"}],"container-title":["Antioxidants &amp; Redox Signaling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/ars.2025.1022","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/ars.2025.1022","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/ars.2025.1022","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T04:41:18Z","timestamp":1783140078000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/ars.2025.1022"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,28]]},"references-count":199,"journal-issue":{"issue":"16-18","published-print":{"date-parts":[[2025,12,1]]}},"alternative-id":["10.1089\/ars.2025.1022"],"URL":"https:\/\/doi.org\/10.1089\/ars.2025.1022","relation":{},"ISSN":["1523-0864","1557-7716"],"issn-type":[{"value":"1523-0864","type":"print"},{"value":"1557-7716","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,28]]}}}