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In this study, a bacterial chromosomal plasmid DNA was used as a model biomolecule that represents a complex polymeric nucleic acid containing genetic information. The plasmid DNA was exposed to UV radiation through a medium containing air, water, iron (Fe\n                    <jats:sup>3+<\/jats:sup>\n                    ), or silica-iron rich aqueous solutions. Our results demonstrate that the plasmid DNA underwent covalent breakage in an aqueous solution when exposed to UV radiation but was shielded against damage due to the presence of iron and silica. It is demonstrated that a suspension of\n                    <jats:italic toggle=\"yes\">ca.<\/jats:italic>\n                    40\u2009nm colloidal particles of silica gel embedded with Fe\n                    <jats:sup>3+<\/jats:sup>\n                    ions adsorbed on silanol groups that formed nanoclusters of noncrystalline iron hydroxide is an extremely efficient shelter against intense UV radiation. The implications for our understanding of primitive Earth and Earth-like planets, moons, and asteroids are discussed. The stability of a chromosomal DNA molecule against UV radiation in the presence of iron and silica may provide support on how macromolecules endured early Earth environments and brought forth important implications on early molecular survival against UV radiation.\n                  <\/jats:p>","DOI":"10.1089\/ast.2022.0004","type":"journal-article","created":{"date-parts":[[2022,10,18]],"date-time":"2022-10-18T20:12:06Z","timestamp":1666123926000},"page":"33-42","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["Investigations on the Role of Iron (III) and Silica-Iron (III) for DNA Protection Against Highly Intense UV Radiation: Tracking the Connection of Prebiotic Chemistry to Biology"],"prefix":"10.1177","volume":"23","author":[{"given":"Luis A.","family":"Gonz\u00e1lez-Ram\u00edrez","sequence":"first","affiliation":[{"name":"Laboratorio de Estudios Cristalogr\u00e1ficos, Instituto Andaluz de Ciencias de la Tierra, CSIC-UGR, Armilla, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abel","family":"Moreno","sequence":"additional","affiliation":[{"name":"Laboratorio de Estudios Cristalogr\u00e1ficos, Instituto Andaluz de Ciencias de la Tierra, CSIC-UGR, Armilla, Spain."},{"name":"Instituto de Qu\u00edmica, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Ciudad de M\u00e9xico, M\u00e9xico."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph D.","family":"Ng","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, University of Alabama in Huntsville, Huntsville, Alabama, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan M.","family":"Garc\u00eda-Ruiz","sequence":"additional","affiliation":[{"name":"Laboratorio de Estudios Cristalogr\u00e1ficos, Instituto Andaluz de Ciencias de la Tierra, CSIC-UGR, Armilla, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,10,18]]},"reference":[{"key":"e_1_3_2_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01808177"},{"key":"e_1_3_2_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-7037(81)90250-7"},{"key":"e_1_3_2_4_1","doi-asserted-by":"publisher","unstructured":"Cismasu AC Michel FM Tcaciuc AP et al. 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