{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T09:46:22Z","timestamp":1777455982480,"version":"3.51.4"},"reference-count":28,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Breastfeeding Medicine"],"published-print":{"date-parts":[[2022,2,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>The colostrum contains macrophage migration inhibitory factor (MIF), which plays an important role in protecting newborns from infections. As such, colostrum may be specifically important to prevent early onset neonatal sepsis among neonates born after premature rupture of membranes (PROM). However, the effect of PROM on the colostral MIF concentration has not been previously described. The aim of this study is to compare the concentration of MIF in the colostrum of mothers with and without PROM.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>The study group consisted of 44 women, 22 of whom had PROM. Colostrum was expressed and collected within 72 hours of birth. MIF concentration was measured using the enzyme-linked immunosorbent assay method and compared between mothers with and without PROM.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      There were no differences between the two groups (PROM group\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u200922, control group\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u200922) with regard to the age of mothers, mode of delivery, neonatal gestational age, birth weight, and sex of the infants (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&gt;\u20090.05). The colostral MIF concentration was significantly higher among mothers with than without PROM (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.0001). There was a positive and significant correlation between the colostral MIF concentration and PROM duration (\n                      <jats:italic toggle=\"yes\">r<\/jats:italic>\n                      \u2009=\u20090.314,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.038).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>PROM was associated with a higher colostral MIF concentration, with this concentration being positively correlated with the duration of PROM. This increased concentration may be important in offering these neonates additional protection against early onset infections, which is a risk associated with PROM.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/bfm.2021.0190","type":"journal-article","created":{"date-parts":[[2022,1,20]],"date-time":"2022-01-20T09:18:14Z","timestamp":1642670294000},"page":"189-193","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Increased Colostral Concentration of Macrophage Migration Inhibitory Factor in Mothers with Premature Rupture of Membranes"],"prefix":"10.1177","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8080-2438","authenticated-orcid":false,"given":"S\u00fcleyman","family":"Bayraktar","sequence":"first","affiliation":[{"name":"Department of Pediatric Intensive Care, Bezmialem Vakif University Faculty of Medicine, Istanbul, Turkey."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bilge","family":"Tanyeri-Bayraktar","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Bezmialem Vakif University Faculty of Medicine, Istanbul, Turkey."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00dclkan","family":"K\u0131l\u0131\u00e7","sequence":"additional","affiliation":[{"name":"Department of Medical Biology, University of Health Sciences Turkey, Istanbul, Turkey."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2022,2,11]]},"reference":[{"key":"e_1_3_6_2_2","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2018-315826"},{"key":"e_1_3_6_3_2","first-page":"e1","article-title":"ACOG practice bulletin no. 188: Prelabor rupture of membranes","volume":"131","author":"Committee on Practice Bulletins-Obstetrics","year":"2018","unstructured":"Committee on Practice Bulletins-Obstetrics. 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