{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,26]],"date-time":"2026-07-26T04:12:53Z","timestamp":1785039173396,"version":"3.55.0"},"reference-count":29,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Breastfeeding Medicine"],"published-print":{"date-parts":[[2022,7,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Granulomatous lobular mastitis (GM) is a rare inflammatory breast disease. Reports focusing on GM caused by antipsychotic-induced hyperprolactinemia (HPRL) are very rare.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim:<\/jats:title>\n                    <jats:p>To report a study of GM associated with antipsychotic-induced HPRL and discuss the mechanism and management.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>A retrospective review of patients with GM and psychiatric disorders were carried out. The clinical characteristics, management and outcome were collected and analyzed. The relationship between antipsychotics and GM was evaluated using the Naranjo Adverse Drug Reaction Probability Scale (Naranjo scale).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Nineteen female GM patients with psychiatric diseases, aged 21\u201339 years, who had received antipsychotics for 0.5\u201310.2 years were included. Most patients took multiple antipsychotics, and 10 (52.6%) took risperidone-containing regimens. Increased prolactin (PRL) was detected in all patients (range 35.15\u2013200\u2009ng\/mL). The scores of Naranjo scale were 7\u20138, indicated the antipsychotics probably induced GM. All patients received systemic therapy, and were prescribed bromocriptine. Seven patients (36.8%) decreased the dose of antipsychotics, six (31.6%) switched antipsychotics, three (15.8%) continued the primary antipsychotics, and three (15.8%) discontinued antipsychotics. In addition, 14 patients (73.7%) received corticosteroid, 4 (21.1%) received antimycobacterials. PRL decreased to normal in 1 month. Seven patients (36.8%) received excisional surgery. After 12 months' follow-up (range 9\u201356 months), only three patients (15.8%) had a recurrence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Long-term use of antipsychotics may increase PRL levels, and lead to GM. It is vital to assess PRL level and reduce PRL to normal in patients with GM.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/bfm.2021.0341","type":"journal-article","created":{"date-parts":[[2022,4,21]],"date-time":"2022-04-21T17:10:45Z","timestamp":1650561045000},"page":"599-604","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":17,"title":["Characteristics and Management of Granulomatous Lobular Mastitis Associated with Antipsychotics-Induced Hyperprolactinemia"],"prefix":"10.1177","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5978-2292","authenticated-orcid":false,"given":"Chunxiang","family":"Tian","sequence":"first","affiliation":[{"name":"Department of Breast Surgery and Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeyu","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Breast Surgery and Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaorong","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Breast Surgery and Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Ning","sequence":"additional","affiliation":[{"name":"Department of Breast Surgery and Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,7,12]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1054\/brst.1999.0072"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/tbj.12552"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/tbj.12914"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2019.01.034"},{"key":"e_1_3_3_6_2","first-page":"1","article-title":"Bacteria associated with granulomatous lobular mastitis and the potential for personalized therapy","volume":"15","author":"Li XQ","year":"2020","unstructured":"Li XQ, , Wu HL, , Yuan JP, et al. Bacteria associated with granulomatous lobular mastitis and the potential for personalized therapy. J Invest Surg, 2020; 15:1\u20137.","journal-title":"J Invest Surg"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.2174\/157488711793980138"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.1981.154"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/58.6.642"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.breast.2015.04.003"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjsurg.2017.07.002"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-9776(03)00032-8"},{"key":"e_1_3_3_13_2","first-page":"e15206","article-title":"Idiopathic granulomatous lobular mastitis: An imitation of breast carcinoma","volume":"13","author":"Aydin I","year":"2021","unstructured":"Aydin I, , Kesicioglu T, , Vural S, et al. Idiopathic granulomatous lobular mastitis: An imitation of breast carcinoma. 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Risperidone induced granulomatous mastitis secondary to hyperprolactinemia in a non-pregnant woman\u2014A rare case report in a bipolar disorder. 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