{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T09:54:41Z","timestamp":1777456481838,"version":"3.51.4"},"reference-count":22,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Breastfeeding Medicine"],"published-print":{"date-parts":[[2024,8,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>: Migraine attacks are common in women of reproductive age. Although attacks are often less severe and less frequent during pregnancy, they regularly reoccur shortly after delivery. When first-line analgesic treatment is insufficient, triptans may be used for acute treatment of migraine attacks. Milk levels of occasional triptan use have shown to be low, and no adverse effects in breastfed infants have been reported. However, the available knowledge on the safety of triptans during breastfeeding is still limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Four (inter)national pharmacovigilance databases were searched for breastfeeding related adverse drug reactions of triptans. These included the Dutch Pregnancy Drug Register and three databases of spontaneous reports (Netherlands Pharmacovigilance Centre Lareb, the European Medicines Agency [EudraVigilance], and the World Health Organization [VigiBase]).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>A total of 26 reports on 27 breastfeeding related adverse drug reactions were identified (one report involved two separate adverse drug reactions). These involve three main complaints: painful breasts and\/or nipples, painful milk ejection reflex, and a decrease in milk production.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion and Conclusion:<\/jats:title>\n                    <jats:p>The hypothesized pharmacological mechanism relates to the serotonin-receptor agonistic properties of triptans. These may lead to vasoconstriction in the breasts and nipples, including the vasculature surrounding the milk ducts and alveoli, and may also influence the hormonal function and levels of prolactin. The reported adverse drug reactions do not negatively impact the overall compatibility of triptans with breastfeeding. However, breastfeeding women may experience them as unsettling. Awareness of these potential adverse drug reactions is essential and should be weighed against the potential adverse effects of (untreated) symptoms of migraine attacks.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/bfm.2024.0022","type":"journal-article","created":{"date-parts":[[2024,4,2]],"date-time":"2024-04-02T09:30:18Z","timestamp":1712050218000},"page":"645-651","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Breastfeeding-Related Adverse Drug Reactions of Triptans: A Descriptive Analysis Using Four Pharmacovigilance Databases"],"prefix":"10.1177","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5185-2372","authenticated-orcid":false,"given":"Maartje","family":"Conijn","sequence":"first","affiliation":[{"name":"Netherlands Pharmacovigilance Centre Lareb, Den Bosch, The Netherlands."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Veronique","family":"Maas","sequence":"additional","affiliation":[{"name":"Netherlands Pharmacovigilance Centre Lareb, Den Bosch, The Netherlands."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miranda","family":"van Tuyl","sequence":"additional","affiliation":[{"name":"Netherlands Pharmacovigilance Centre Lareb, Den Bosch, The Netherlands."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4130-5869","authenticated-orcid":false,"given":"Michael","family":"Ceulemans","sequence":"additional","affiliation":[{"name":"KU Leuven, Department of Pharmaceutical and Pharmacological Sciences, Leuven, Belgium."},{"name":"L-C&amp;Y, KU Leuven Child and Youth Institute, Leuven, Belgium."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Judith","family":"Hendriks","sequence":"additional","affiliation":[{"name":"Netherlands Pharmacovigilance Centre Lareb, Den Bosch, The Netherlands."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Florence","family":"van Hunsel","sequence":"additional","affiliation":[{"name":"Netherlands Pharmacovigilance Centre Lareb, Den Bosch, The Netherlands."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annerose","family":"van der Mijle","sequence":"additional","affiliation":[{"name":"Netherlands Pharmacovigilance Centre Lareb, Den Bosch, The Netherlands."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2024,8,26]]},"reference":[{"issue":"1","key":"e_1_3_5_2_2","first-page":"023","article-title":"Global, regional, and national epidemiology of migraine and tension-type headache in youths and young adults aged 15-39 years from 1990 to 2019: Findings from the global burden of disease study 2019","volume":"24","author":"Li XY","year":"2023","unstructured":"Li XY, , Yang CH, , Lv JJ, et al. Global, regional, and national epidemiology of migraine and tension-type headache in youths and young adults aged 15-39 years from 1990 to 2019: Findings from the global burden of disease study 2019. J Headache Pain, 2023; 24(1):023\u201301659.","journal-title":"J Headache Pain"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-020-04643-8"},{"issue":"3","key":"e_1_3_5_4_2","first-page":"e36828","article-title":"Relation and treatment approach of migraine in pregnancy and breastfeeding","volume":"15","author":"Turankar T","year":"2023","unstructured":"Turankar T, , Sorte A, , Wanjari MB, et al. Relation and treatment approach of migraine in pregnancy and breastfeeding. 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