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Currently, ovarian tissue cryopreservation (OTC) is the only option for fertility preservation available to preadolescent females. Ovarian tissue can be harvested for cryopreservation laparoscopically without delaying cancer treatment. Although OTC is an experimental and rapidly evolving area of research, it has shown success in humans, with several live births reported thus far. Therefore, an analysis of OTC and its suitability for preadolescent females is appropriate at this time. Future research directions will allow OTC to transition from an experimental method with limited availability to a viable option for preadolescent cancer patients. 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