{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T12:59:21Z","timestamp":1777467561979,"version":"3.51.4"},"reference-count":10,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T00:00:00Z","timestamp":1543622400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T00:00:00Z","timestamp":1543622400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Biopreservation and Biobanking"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>The Cooperative Human Tissue Network, Midwestern Division, is a National Cancer Institute-funded program that provides quality research biospecimens to qualified investigators. Consented human tissues are procured according to researcher specifications for weight (size) and preservation type; weights of samples in significant demand and limited supply are negotiated. Weights of procured tissues are entered into a dedicated biospecimen database. This study seeks to provide guidance for acceptable tissue weights for researchers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Tissue weights by year and anatomic site were retrieved from the database for primary malignant tissues. The total number of tissues included was 5141. Statistical evaluation of data included the number of tissues for each year, anatomic site as well as minimum, maximum, average weights, standard deviation, and standard error. Anatomic sites with few tissues were excluded.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\u201cStock price\u201d type graphs were constructed to show an average as \u201cvolume\u201d with both full weight ranges and range that accommodated 80% of tissues. Average weight and number of sample trends varied by anatomic site. Tissues fell into four weight groups; 10 and 90 percentile boundaries were calculated for each. Smallest average research tissue weights for middle 80% were recorded for prostate and oropharynx (140\u2009mg). Second weight group included tonsil, thyroid, breast, oral cavity, larynx, pancreas, salivary gland, skin, tongue, lung, and parotid (265\u2009mg). The third group included stomach, cervix, colon, esophagus, endometrium, bone, brain, bladder, small bowel, uterus, liver, kidney lymph node, adrenal, and ovary (513\u2009mg). The fourth and heaviest weight group included soft tissue tumors and spleen (1201\u2009mg).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Since tissue weights are not usually included in recommendations for research tissue procurement or for frozen tissues stored in biorepositories, we offer this data as a practical guide to researcher acceptable tissue weights for selected sites based on a 3-year researcher request and acceptance history.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/bio.2018.0068","type":"journal-article","created":{"date-parts":[[2018,10,31]],"date-time":"2018-10-31T16:59:25Z","timestamp":1541005165000},"page":"463-466","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Acceptable Weight Ranges for Research Tissue Procurement and Biorepositories, 2015\u20132017"],"prefix":"10.1177","volume":"16","author":[{"given":"David G.","family":"Nohle","sequence":"first","affiliation":[{"name":"Ohio Consortium, Cooperative Human Tissue Network (CHTN) Midwestern Division, Columbus, Ohio."},{"name":"Department of Pathology, The Ohio State University, Columbus, Ohio."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Randal L.","family":"Mandt","sequence":"additional","affiliation":[{"name":"Ohio Consortium, Cooperative Human Tissue Network (CHTN) Midwestern Division, Columbus, Ohio."},{"name":"Department of Pathology, The Ohio State University, Columbus, Ohio."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta E.","family":"Couce","sequence":"additional","affiliation":[{"name":"Ohio Consortium, Cooperative Human Tissue Network (CHTN) Midwestern Division, Columbus, Ohio."},{"name":"Department of Pathology, Case Western Reserve University, Cleveland, Ohio."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anil V.","family":"Parwani","sequence":"additional","affiliation":[{"name":"Ohio Consortium, Cooperative Human Tissue Network (CHTN) Midwestern Division, Columbus, Ohio."},{"name":"Department of Pathology, The Ohio State University, Columbus, Ohio."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leona W.","family":"Ayers","sequence":"additional","affiliation":[{"name":"Ohio Consortium, Cooperative Human Tissue Network (CHTN) Midwestern Division, Columbus, Ohio."},{"name":"Department of Pathology, The Ohio State University, Columbus, Ohio."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2018,12,17]]},"reference":[{"key":"e_1_3_3_2_2","unstructured":"CHTN Midwestern Division. Available at: https:\/\/wexnermedical.osu.edu\/human-tissue-resource-network\/collaborative-human-tissue-network (accessed October5 2018)."},{"key":"e_1_3_3_3_2","unstructured":"CHTN. Available at: https:\/\/www.chtn.org\/ (accessed October5 2018)."},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-3204-7_1"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2013-0691-RA"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1089\/bio.2016.0018"},{"key":"e_1_3_3_7_2","unstructured":"NCI Best Practices for Biospecimen Resources. Available at: https:\/\/biospecimens.cancer.gov\/bestpractices\/ (accessed October5 2018)."},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1089\/bio.2018.0001"},{"key":"e_1_3_3_9_2","first-page":"A33","volume-title":"ISBER Annual Meeting and Exhibit, Westin Harbour Castle Hotel","author":"Mandt RL","year":"2017","unstructured":"Mandt RL, , Nohle DG, , MacLennan GT, et al. Midwestern Cooperative Human Tissue Network (MW CHTN\/NCI) provides investigator requested custom biospecimen preparation and preservation types, 2016. ISBER Annual Meeting and Exhibit, Westin Harbour Castle Hotel, Toronto, Canada, May 9\u201312, 2017. Published abstract in Biopreserv Biobank. 2017; 15:A33."},{"key":"e_1_3_3_10_2","unstructured":"The Cooperative Human Tissue Network. Histologic quality control assessment of tissue samples procured for research purposes: Procedures used by The Cooperative Human Tissue Network. Prepared: December 2006; Updated: November 2014. Available at: https:\/\/www.chtn.org\/quality.html (accessed October5 2018)."},{"key":"e_1_3_3_11_2","volume-title":"International Society for Biological and Environmental Repositories (ISBER) 2018 Annual Meeting","author":"Mandt RL","year":"2018","unstructured":"Mandt RL, , Nohle DG, , Couce ME, et al. MW CHTN researcher requested tissue sample sizes (weight) distributed, 2015\u20132017: Supporting data for biorepository research tissue sample weights for storage. International Society for Biological and Environmental Repositories (ISBER) 2018 Annual Meeting, Hyatt Regency Dallas, Dallas, TX, May 20\u201324, 2018."}],"container-title":["Biopreservation and Biobanking"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/bio.2018.0068","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/bio.2018.0068","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/bio.2018.0068","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T13:31:13Z","timestamp":1777383073000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/full\/10.1089\/bio.2018.0068"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12]]},"references-count":10,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2018,12]]}},"alternative-id":["10.1089\/bio.2018.0068"],"URL":"https:\/\/doi.org\/10.1089\/bio.2018.0068","relation":{},"ISSN":["1947-5535","1947-5543"],"issn-type":[{"value":"1947-5535","type":"print"},{"value":"1947-5543","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,12]]}}}