{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:09:39Z","timestamp":1787008179451,"version":"build-2736575974"},"reference-count":28,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Biopreservation and Biobanking"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:p>\n                    Parathyroidectomy is a standard practice to treat recurrent or persistent hyperparathyroidism. However, this can lead to the onset of hypoparathyroidism, treatable with the autotransplantation of parathyroid tissue (PT). Tissue can be transplanted immediately after parathyroidectomy or cryopreserved and transplanted only in case of necessity. Since 2011, the Cord Blood Bank and Cardiovascular Tissue Bank of Emilia-Romagna has been storing PT for potential autologous transplantation. To date, there are highly variable data about the viability and function of PT after thawing. However, it is not clear if the PT quality is affected by different cryopreservation protocols and\/or by the storage time. The aim of this study was to assess the\n                    <jats:italic toggle=\"yes\">ex vivo<\/jats:italic>\n                    function and viability of the PTs of ten patients stored in the Bank. Tissue morphology was evaluated before and after cryopreservation through histological investigations. PT function was analyzed by assessing the ability of cryopreserved PT to synthesize and secrete parathyroid hormone (PTH) in response to different calcium concentrations. Moreover, viability and function were also investigated on tissue-isolated cells in culture. These data show that tested tissues appear to be viable and able to produce PTH even after 5 years of storage, and the histological architecture is well preserved.\n                  <\/jats:p>","DOI":"10.1089\/bio.2018.0140","type":"journal-article","created":{"date-parts":[[2019,4,26]],"date-time":"2019-04-26T10:51:30Z","timestamp":1556275890000},"page":"418-424","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["Parathyroid Tissue Cryopreservation: Does the Storage Time Affect Viability and Functionality?"],"prefix":"10.1177","volume":"17","author":[{"given":"Annalisa","family":"Aiti","sequence":"first","affiliation":[{"name":"Emilia Romagna Cord Blood Bank, Immunohaematology and Transfusion Medicine, St. Orsola-Malpighi University Hospital, Bologna, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Rossi","sequence":"additional","affiliation":[{"name":"Unit of Histology, Embryology and Applied Biology, Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Alviano","sequence":"additional","affiliation":[{"name":"Unit of Histology, Embryology and Applied Biology, Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Morara","sequence":"additional","affiliation":[{"name":"Emilia Romagna Cord Blood Bank, Immunohaematology and Transfusion Medicine, St. Orsola-Malpighi University Hospital, Bologna, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Burgio","sequence":"additional","affiliation":[{"name":"Otolaringology Unit, St. Orsola-Malpighi University Hospital, Bologna, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleonora","family":"Cioccoloni","sequence":"additional","affiliation":[{"name":"Otolaringology Unit, St. Orsola-Malpighi University Hospital, Bologna, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ottavio","family":"Cavicchi","sequence":"additional","affiliation":[{"name":"Otolaringology Unit, St. Orsola-Malpighi University Hospital, Bologna, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianandrea","family":"Pasquinelli","sequence":"additional","affiliation":[{"name":"Unit of Surgical Pathology, Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Bonsi","sequence":"additional","affiliation":[{"name":"Unit of Histology, Embryology and Applied Biology, Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Buzzi","sequence":"additional","affiliation":[{"name":"Emilia Romagna Cord Blood Bank, Immunohaematology and Transfusion Medicine, St. Orsola-Malpighi University Hospital, Bologna, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2019,10,10]]},"reference":[{"key":"e_1_3_2_2_2","first-page":"249","article-title":"Parathyroid disorders","volume":"88","author":"Michels TC","year":"2013","unstructured":"Michels TC, , Kelly KM. Parathyroid disorders. Am Fam Physician, 2013; 88:249\u2013257.","journal-title":"Am Fam Physician"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200012213432508"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)60507-9"},{"key":"e_1_3_2_5_2","first-page":"2389","article-title":"Clinical practice","volume":"365","author":"Marcocci C","year":"2011","unstructured":"Marcocci C, , Cetani F. Clinical practice. Primary hyperparathyroidism. N Engl J Med, 2011; 365:2389\u20132397.","journal-title":"Primary hyperparathyroidism. 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