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In combination, these transport mechanisms set the resting potential, regulate cell volume, and strongly modulate responses of the chondrocyte to endocrine agents and physicochemical alterations in the surrounding extracellular microenvironment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>\n                      Mathematical modeling was used to assess the functional roles of energy-requiring active transport, the Na\n                      <jats:sup>+<\/jats:sup>\n                      \/K\n                      <jats:sup>+<\/jats:sup>\n                      pump, in chondrocytes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Our findings illustrate plausible physiological roles for the Na\n                      <jats:sup>+<\/jats:sup>\n                      \/K\n                      <jats:sup>+<\/jats:sup>\n                      pump in regulating the resting membrane potential and suggest ways in which specific molecular components of pump can respond to the unique electrochemical environment of the chondrocyte.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>This analysis provides a basis for linking chondrocyte electrophysiology to metabolism and yields insights into novel ways of manipulating or regulating responsiveness to external stimuli both under baseline conditions and in chronic diseases such as osteoarthritis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/bioe.2020.0036","type":"journal-article","created":{"date-parts":[[2020,9,17]],"date-time":"2020-09-17T10:49:22Z","timestamp":1600339762000},"page":"258-268","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Physiological Effects of the Electrogenic Current Generated by the Na\n                    <sup>+<\/sup>\n                    \/K\n                    <sup>+<\/sup>\n                    Pump in Mammalian Articular Chondrocytes"],"prefix":"10.1177","volume":"2","author":[{"given":"Mary M.","family":"Maleckar","sequence":"first","affiliation":[{"name":"Simula Research Laboratory, Inc., Oslo, Norway."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pablo","family":"Mart\u00edn-Vasallo","sequence":"additional","affiliation":[{"name":"UD of Biochemistry and Molecular Biology, Universidad de La Laguna, San Crist\u00f3bal de La Laguna, Spain."},{"name":"Instituto de Tecnolog\u00edas Biom\u00e9dicas de Canarias, Universidad de La Laguna, San Crist\u00f3bal de La Laguna, Spain."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wayne R.","family":"Giles","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology, University of Calgary, Calgary, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali","family":"Mobasheri","sequence":"additional","affiliation":[{"name":"Research Unit of Medical Imaging, Physics and Technology, Faculty of Medicine, University of Oulu, Oulu, Finland."},{"name":"Department of Regenerative Medicine, State Research Institute Centre for Innovative Medicine, Vilnius, Lithuania."},{"name":"Department of Orthopedics, Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, The Netherlands."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2020,9,16]]},"reference":[{"key":"e_1_3_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.berh.2011.11.013"},{"key":"e_1_3_6_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7580.2006.00546.x"},{"key":"e_1_3_6_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/wsbm.157"},{"key":"e_1_3_6_5_2","doi-asserted-by":"publisher","DOI":"10.4137\/CMAMD.S22147"},{"key":"e_1_3_6_6_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.16415"},{"key":"e_1_3_6_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.34520"},{"key":"e_1_3_6_8_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0125192"},{"key":"e_1_3_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2011.01.003"},{"key":"e_1_3_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1357-2725(02)00301-1"},{"key":"e_1_3_6_11_2","first-page":"893","article-title":"Ion transport in chondrocytes: Membrane transporters involved in intracellular ion homeostasis and the regulation of cell volume, free [Ca2+] and pH","volume":"13","author":"Mobasheri A","year":"1998","unstructured":"Mobasheri A, , Mobasheri R, , Francis MJ, et al. 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