{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T11:46:56Z","timestamp":1789213616236,"version":"build-2803163510"},"reference-count":66,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Brain Connectivity"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>Cerebral small vessel disease (CSVD) is a primary vascular disease of cognitive impairment. Previous studies have predominantly focused on brain linear features. However, the nonlinear measure, brain entropy (BEN), has not been elaborated. Thus, this study aims to investigate if BEN abnormalities could manifest in CSVD patients with cognitive impairment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Thirty-four CSVD patients with cognitive impairment and 37 healthy controls (HCs) were recruited. Analysis of gray matter approximate entropy (ApEn) and sample entropy (SampEn) which are two indices of BEN was calculated. To explore whether BEN can provide unique information, we further performed brain linear methods, namely, amplitude of low frequency fluctuation (ALFF) and regional homogeneity (ReHo), to observe their differences. The ratios of BEN\/ALFF and BEN\/ReHo which represent the coupling of nonlinear and linear features were introduced. Correlation analysis was conducted between imaging indices and cognition. Subsequently, the linear support vector machine (SVM) was used to assess their discriminative ability.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>CSVD patients exhibited lower ApEn and SamEn values in sensorimotor areas, which were correlated with worse memory and executive function. In addition, the results of BEN showed little overlap with ALFF and ReHo in brain regions. Correlation analysis also revealed a relationship between the two ratios and cognition. SVM analysis using BEN and its ratios as features achieved an accuracy of 74.64% (sensitivity: 86.49%, specificity: 61.76%, and AUC: 0.82439).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Our study reveals that the reduction of sensorimotor system complexity is correlated with cognition. BEN exhibits distinctive characteristics in brain activity. Combining BEN and the ratios can be new biomarkers to diagnose CSVD with cognitive impairment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Impact Statement<\/jats:title>\n                    <jats:p>Cerebral small vessel disease (CSVD) is regarded as the most important vascular disease of cognitive impairment. However, conventional brain imaging fails to adequately elucidate the pathogenesis of cognitive disorder related to CSVD. In this regard, exploring brain entropy (BEN) based on resting-state functional magnetic resonance imaging (rs-fMRI) represents a relatively novel and unexplored approach in the context of CSVD. This approach provides novel insights into the pathogenesis, diagnosis, and rehabilitation of cognitive disorder associated with CSVD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/brain.2024.0007","type":"journal-article","created":{"date-parts":[[2024,7,13]],"date-time":"2024-07-13T09:12:56Z","timestamp":1720861976000},"page":"418-429","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["Altered Resting-State Brain Entropy in Cerebral Small Vessel Disease Patients with Cognitive Impairment"],"prefix":"10.1177","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-3741-1291","authenticated-orcid":false,"given":"Ying","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Neurology, The First Affiliated Hospital of Anhui Medical University, Hefei, China."},{"name":"Anhui Province Key Laboratory of Cognition and Neuropsychiatric Disorders, Hefei, 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China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baogen","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Neurology, The First Affiliated Hospital of Anhui Medical University, Hefei, China."},{"name":"Anhui Province Key Laboratory of Cognition and Neuropsychiatric Disorders, Hefei, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanshan","family":"Yin","sequence":"additional","affiliation":[{"name":"Department of Neurology, The First Affiliated Hospital of Anhui Medical University, Hefei, China."},{"name":"Anhui Province Key Laboratory of Cognition and Neuropsychiatric Disorders, Hefei, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Long","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurology, The First Affiliated Hospital of Anhui Medical University, Hefei, China."},{"name":"Anhui Province Key Laboratory of Cognition and Neuropsychiatric Disorders, Hefei, China."},{"name":"Collaborative Innovation Center of Neuropsychiatric Disorders and Mental Health, Anhui Province, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanghua","family":"Tian","sequence":"additional","affiliation":[{"name":"Department of Neurology, The First Affiliated Hospital of Anhui Medical University, Hefei, China."},{"name":"Collaborative Innovation Center of Neuropsychiatric Disorders and Mental Health, Anhui Province, China."},{"name":"The College of Mental Health and Psychological Sciences, Anhui Medical University, Hefei, China."},{"name":"Department of Neurology, The Second Affiliated Hospital of Anhui Medical University, Hefei, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology, The First Affiliated Hospital of Anhui Medical University, Hefei, China."},{"name":"Anhui Province Key Laboratory of Cognition and 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