{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T11:13:01Z","timestamp":1774005181398,"version":"3.50.1"},"reference-count":39,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T00:00:00Z","timestamp":1535760000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T00:00:00Z","timestamp":1535760000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Caffeine and Adenosine Research"],"published-print":{"date-parts":[[2018,9,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background and Aim:<\/jats:title>\n                    <jats:p>To analyze the influence on weight gain of infants exposed to two dosage regimens of oral caffeine citrate (CC) for apnea of prematurity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Retrospective descriptive observational study of an eligible very low birth weight cohort over a 15-year period in an Irish University hospital. Data were analyzed between two distinct postnatal ages: 14\u201328 and 29\u201356 days.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      During the 15-year study, 457 infants were prescribed caffeine. Among the 14\u201328-day group, after applying exclusion criteria, 418 infants qualified. Two hundred forty-eight infants received 5\u2009mg\/(kg\u00b7day) and 170 received 10\u2009mg\/(kg\u00b7day) of CC. Among the 29\u201356-day group, 362 infants were identified and after applying exclusions, 332 fulfilled entry criteria [214 on 5\u2009mg\/(kg\u00b7day) and 118 on 10\u2009mg\/(kg\u00b7day) regimen]. Baseline characteristics of infants were comparable between groups without statistically significant differences. Mean daily weight gain (MDWG) in grams from day 14 to 28 showed a higher rate of increase for the 5\u2009mg\/(kg\u00b7day) group compared with the 10\u2009mg\/(kg\u00b7day) group (17.2\u2009\u00b1\u200912\u2009g vs. 13.0\u2009\u00b1\u200910.2\u2009g [\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.04]). From day 29 to 56, also MDWG was higher among infants on 5\u2009mg\/(kg\u00b7day) of CC compared with 10\u2009mg\/(kg\u00b7day) group (15.6\u2009\u00b1\u200910.8\u2009g vs. 10.2\u2009\u00b1\u20099.8\u2009g [\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.011]).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>While a variety of measures are optimized to promote postnatal weight gain of premature infants close to an ideal intrauterine growth curve, not paying sufficient attention to one of the most widely used catabolic agents in neonatology is questionable and warrants vigilance. Additional nutritional measures could be offered to those with prolonged caffeine exposure.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/caff.2018.0005","type":"journal-article","created":{"date-parts":[[2018,9,10]],"date-time":"2018-09-10T15:04:39Z","timestamp":1536591879000},"page":"99-106","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":13,"title":["Caffeine Treatment for Apnea of Prematurity and the Influence on Dose-Dependent Postnatal Weight Gain Observed Over 15 Years"],"prefix":"10.1177","volume":"8","author":[{"given":"Roy K.","family":"Philip","sequence":"first","affiliation":[{"name":"University Maternity Hospital Limerick (UMHL)","place":["Ireland"]},{"name":"University of Limerick","place":["Ireland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abu","family":"Ismail","sequence":"additional","affiliation":[{"name":"University Maternity Hospital Limerick (UMHL)","place":["Ireland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernadette","family":"Murphy","sequence":"additional","affiliation":[{"name":"University Hospital Limerick (UHL)","place":["Ireland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adnan","family":"Mirza","sequence":"additional","affiliation":[{"name":"University Maternity Hospital Limerick (UMHL)","place":["Ireland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Collette","family":"Quinn","sequence":"additional","affiliation":[{"name":"University Maternity Hospital Limerick (UMHL)","place":["Ireland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margo","family":"Dunworth","sequence":"additional","affiliation":[{"name":"University Maternity Hospital Limerick (UMHL)","place":["Ireland"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2018,9,1]]},"reference":[{"issue":"2","key":"e_1_3_4_2_2","doi-asserted-by":"crossref","first-page":"S47","DOI":"10.1542\/peds.2005-0620H","article-title":"Summary proceedings from the apnea-of-prematurity group","volume":"117","author":"Finer NN","year":"2006","unstructured":"Finer NN, , Higgins R, , Kattwinkel J, , Martin RJ. 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