{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T10:48:37Z","timestamp":1790765317555,"version":"4.1.0"},"reference-count":67,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Cannabis &amp; Cannabinoid Research"],"published-print":{"date-parts":[[2022,2,1]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>\n                      Cannabinoid hyperemesis syndrome (CHS) is characterized by intense nausea and vomiting brought on by the use of high-dose \u0394\n                      <jats:sup>9<\/jats:sup>\n                      -tetrahydrocannabinol (THC), the main psychotropic compound in cannabis. Cannabidiol (CBD), a nonpsychotropic compound found in cannabis, has been shown to interfere with some acute aversive effects of THC. In this study, we evaluated if CBD would interfere with THC-induced nausea through a 5-HT\n                      <jats:sub>1A<\/jats:sub>\n                      receptor mechanism as it has been shown to interfere with nausea produced by lithium chloride (LiCl). Since CHS has been attributed to a dysregulated stress response, we also evaluated if CBD would interfere with THC-induced increase in corticosterone (CORT).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>\n                      The potential of CBD (5\u2009mg\/kg, ip) to suppress THC-induced conditioned gaping (a measure of nausea) was evaluated in rats, as well as the potential of the 5-HT\n                      <jats:sub>1A<\/jats:sub>\n                      receptor antagonist, WAY-100635 (WAY; 0.1\u2009mg\/kg, ip), to reverse the suppression of THC-induced conditioned gaping by CBD. Last, the effect of CBD (5\u2009mg\/kg, ip) on THC-induced increase in serum CORT concentration was evaluated.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Pretreatment with CBD (5\u2009mg\/kg, ip) interfered with the establishment of THC-induced conditioned gaping (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      =0.007, relative to vehicle [VEH] pretreatment), and this was reversed by pretreatment with 0.1\u2009mg\/kg WAY. This dose of WAY had no effect on gaping on its own. THC (10\u2009mg\/kg, ip) significantly increased serum CORT compared with VEH-treated rats (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      =0.04). CBD (5\u2009mg\/kg, ip) pretreatment reversed the THC-induced increase in CORT.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>\n                      CBD attenuated THC-induced nausea as well as THC-induced elevation in CORT. The attenuation of THC-induced conditioned gaping by CBD was mediated by its action on 5-HT\n                      <jats:sub>1A<\/jats:sub>\n                      receptors, similar to that of LiCl-induced nausea.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/can.2020.0083","type":"journal-article","created":{"date-parts":[[2020,12,21]],"date-time":"2020-12-21T17:00:50Z","timestamp":1608570050000},"page":"58-64","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":16,"title":["Cannabidiol Interferes with Establishment of \u0394\n                    <sup>9<\/sup>\n                    -Tetrahydrocannabinol-Induced Nausea Through a 5-HT\n                    <sub>1A<\/sub>\n                    Mechanism"],"prefix":"10.1177","volume":"7","author":[{"given":"Marieka V.","family":"DeVuono","sequence":"first","affiliation":[{"name":"Department of Psychology and Collaborative Neuroscience Program, University of Guelph, Guelph, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivia","family":"La Caprara","sequence":"additional","affiliation":[{"name":"Department of Psychology and Collaborative Neuroscience Program, University of Guelph, Guelph, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gavin N.","family":"Petrie","sequence":"additional","affiliation":[{"name":"Department of Cell Biology and Anatomy, Hotchkiss Brain Institute, University of Calgary, Calgary, Canada."},{"name":"Department of Psychiatry, Hotchkiss Brain Institute, University of Calgary, Calgary, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheryl L.","family":"Limebeer","sequence":"additional","affiliation":[{"name":"Department of Psychology and Collaborative Neuroscience Program, University of Guelph, Guelph, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin M.","family":"Rock","sequence":"additional","affiliation":[{"name":"Department of Psychology and Collaborative Neuroscience Program, University of Guelph, Guelph, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew N.","family":"Hill","sequence":"additional","affiliation":[{"name":"Department of Cell Biology and Anatomy, Hotchkiss Brain Institute, University of Calgary, Calgary, Canada."},{"name":"Department of Psychiatry, Hotchkiss Brain Institute, University of Calgary, Calgary, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda A.","family":"Parker","sequence":"additional","affiliation":[{"name":"Department of Psychology and Collaborative Neuroscience Program, University of Guelph, Guelph, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,2,10]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2003.036350"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s13181-016-0595-z"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.13606"},{"key":"e_1_3_3_5_2","doi-asserted-by":"crossref","unstructured":"DeVuono MV Parker LA . 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