{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T17:12:38Z","timestamp":1782321158029,"version":"3.54.5"},"reference-count":24,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Cannabis &amp; Cannabinoid Research"],"published-print":{"date-parts":[[2023,2,1]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>A recent law (DCTO-2020-883-APN-PTE\u2014Law No. 27,350. Regulation) passed in Argentina put an end to the ban imposed for the last 60 years on cannabis cultivation within the country. The law permits restricted access to cannabis derivatives for medicinal, therapeutic, and palliative use by individuals and communities, allowing self- and community-based cannabis production. This is cause for concern in view of the lack of quality controls for cannabis derivatives. The several varieties of cannabis grown in Argentina have different chemical profiles and are processed in a variety of ways\u2014mostly by alcohol extraction or maceration at different temperatures and for different amounts of times\u2014making the cannabinoid content of these preparations highly variable. Determining the characteristics of home- and community-grown cannabis products will facilitate the implementation of public policies conducive to their safety and improvement.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>The aim of this study was to determine the cannabinoid chemotypes used for therapeutic purposes in Argentina and evaluate whether the cannabinoids present in homemade derivatives are comparable to those in commercially available products.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>High performance liquid chromatography with ultraviolet and diode array detector (HPLC\/UV-DAD) analysis of 436 samples (oils, resins, and inflorescences) was carried out to determine the identity and concentration of five cannabinoids: tetrahydrocannabinolic acid (THCA), tetrahydrocannabinol (THC), cannabidiolic acid (CBDA), cannabidiol (CBD), and cannabinol (CBN). From three different sources, the samples represent the type of medical cannabis preparations to which patients have access.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>The results indicate that the medium-to-low cannabinoid concentration in a significant number of homemade oil samples is similar to that found in commercial products. Most of the samples have a THC\/CBD ratio &gt;1 or only contain THC. Acidic cannabinoids were detected in homemade preparations, but were not reported in package inserts of commercial products.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Our results indicate that despite their considerable variability, homemade preparations as a whole show cannabinoid levels and profiles equivalent to the commercially available products commonly used for medicinal, therapeutic, and palliative purposes in Argentina.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/can.2020.0117","type":"journal-article","created":{"date-parts":[[2021,3,26]],"date-time":"2021-03-26T16:29:52Z","timestamp":1616776192000},"page":"197-206","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["Cannabinoid Content in Cannabis Flowers and Homemade Cannabis-Based Products Used for Therapeutic Purposes in Argentina"],"prefix":"10.1177","volume":"8","author":[{"given":"Daniela","family":"Sedan","sequence":"first","affiliation":[{"name":"Environmental Research Center, National Council for Scientific and Technical Research CIM UNLP-CONICET, La Plata, Argentina."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristian","family":"Vaccarini","sequence":"additional","affiliation":[{"name":"Environmental Research Center, National Council for Scientific and Technical Research CIM UNLP-CONICET, La Plata, Argentina."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo","family":"Demetrio","sequence":"additional","affiliation":[{"name":"Environmental Research Center, National Council for Scientific and Technical Research CIM UNLP-CONICET, La Plata, Argentina."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelo","family":"Morante","sequence":"additional","affiliation":[{"name":"Medicine School of La Plata National University UNLP, La Plata, Argentina."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romina","family":"Montiel","sequence":"additional","affiliation":[{"name":"Palliative Care Service of the Oncology Institute Angel H. Roffo IOAR, National University of Buenos Aires, UBA, Buenos Aires, Argentina."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alvaro","family":"Saur\u00ed","sequence":"additional","affiliation":[{"name":"Palliative Care Service of the Oncology Institute Angel H. Roffo IOAR, National University of Buenos Aires, UBA, Buenos Aires, Argentina."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dario","family":"Andrinolo","sequence":"additional","affiliation":[{"name":"Environmental Research Center, National Council for Scientific and Technical Research CIM UNLP-CONICET, La Plata, Argentina."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,2,6]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s13311-015-0374-6"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.beem.2008.10.013"},{"key":"e_1_3_4_4_2","first-page":"3","volume-title":"Cannabis sativa","author":"ElSohly MA","unstructured":"ElSohly MA, , Gul W. Constituents of Cannabis sativa. In: Pertwee R, ed. Handbook of cannabis. 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The Haworth Press: Binghamton New York 2002. pp. 27\u201336."},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1089\/can.2016.0032"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.108.020909"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2011.01238.x"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2009.11.004"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jnatprod.9b01200"},{"key":"e_1_3_4_19_2","unstructured":"Ramos Atance JA . Efectos Terap\u00e9uticos de los Cannabinoides . Ed: Instituto Universitario de Investigaci\u00f3n en Neuroqu\u00edmica de la Universidad Complutense de Madrid. 2017. http:\/\/www.seic.es\/wp-content\/uploads\/2013\/10\/EFECTOS-TERAP%C3%89UTICOS-DE-LOS-CANNABINOIDES.pdf (accessed March15 2021)."},{"key":"e_1_3_4_20_2","first-page":"1521","article-title":"Oral cannabidiol use in children with autism spectrum disorder to treat related symptoms and co-morbidities","volume":"9","author":"Berkovitch M","year":"2018","unstructured":"Berkovitch M, , Barchel D, , Stolar O, et al. Oral cannabidiol use in children with autism spectrum disorder to treat related symptoms and co-morbidities. 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