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With the currently available treatments, vomiting and especially nausea remain problematic, highlighting the need for alternative treatments.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion:<\/jats:title>\n                    <jats:p>\n                      Here we review\n                      <jats:italic toggle=\"yes\">in vitro<\/jats:italic>\n                      and\n                      <jats:italic toggle=\"yes\">in vivo<\/jats:italic>\n                      evidence for the effectiveness of the nonpsychoactive cannabinoid cannabidiol (CBD) in managing nausea and vomiting. In addition, we also review the evidence for CBD's acidic precursor, cannabidiolic acid (CBDA), and a methylated version of CBDA (CBDA-ME) in these phenomena. Finally, we explore the potential role of CBD in the treatment of cannabinoid hyperemesis syndrome.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>CBD has demonstrated efficacy in reducing nausea and vomiting, with CBDA and CBDA-ME being more potent. The data suggest a need for these compounds to be evaluated in clinical trials for their ability to reduce nausea and\/or vomiting.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/can.2021.0041","type":"journal-article","created":{"date-parts":[[2021,6,11]],"date-time":"2021-06-11T17:12:10Z","timestamp":1623431530000},"page":"266-274","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":33,"title":["Therapeutic Potential of Cannabidiol, Cannabidiolic Acid, and Cannabidiolic Acid Methyl Ester as Treatments for Nausea and Vomiting"],"prefix":"10.1177","volume":"6","author":[{"given":"Erin M.","family":"Rock","sequence":"first","affiliation":[{"name":"Collaborative Neuroscience Program, Department of Psychology, University of Guelph, Guelph, Ontario, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheryl L.","family":"Limebeer","sequence":"additional","affiliation":[{"name":"Collaborative Neuroscience Program, Department of Psychology, University of Guelph, Guelph, Ontario, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger G.","family":"Pertwee","sequence":"additional","affiliation":[{"name":"School of Medicine, Medical Sciences and Nutrition, Institute of Medical Sciences, University of Aberdeen, Aberdeen, Scotland, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raphael","family":"Mechoulam","sequence":"additional","affiliation":[{"name":"Institute for Drug Research, Medical Faculty, The Hebrew University of Jerusalem, Jerusalem, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3494-9754","authenticated-orcid":false,"given":"Linda A.","family":"Parker","sequence":"additional","affiliation":[{"name":"Collaborative Neuroscience Program, Department of Psychology, University of Guelph, Guelph, Ontario, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,8,5]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1515442"},{"key":"e_1_3_3_3_2","first-page":"3141","article-title":"Chemotherapy-induced nausea and vomiting in clinical practice: impact on patients' quality of life","volume":"20","author":"Fern\u00e1ndez-Ortega P","year":"2012","unstructured":"Fern\u00e1ndez-Ortega P, , Caloto MT, , Chirveches E, et al. 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