{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T22:54:10Z","timestamp":1788562450186,"version":"build-2803163510"},"reference-count":87,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Cannabis &amp; Cannabinoid Research"],"published-print":{"date-parts":[[2022,10,1]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>Among adolescents and young adults, cannabis use is prevalent. Prior studies characterizing withdrawal effects in this age range have primarily included treatment seeking or comorbid psychiatric samples; these studies have identified several affected domains, especially sleep, mood, and anxiety. The present study compared a community (i.e., nontreatment seeking) sample of cannabis-using and control participants on mood, anxiety, sleep, and withdrawal inventories during the course of a monitored 3-week cannabis abstinence period.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>Seventy-nine adolescent and young adult participants (cannabis-using group=37 and control group=42) were recruited from the community to undergo 3 weeks of confirmed abstinence (i.e., urine and sweat patch toxicology) and completion of Cannabis Withdrawal Symptom Criteria, State-Trait Anxiety Inventory, Beck's Depression Inventory, and Pittsburgh Sleep Quality Index across the study period. Repeated measures and cross-sectional regressions were used to examine main effects of group and interactions with time (where appropriate), while accounting for recent alcohol use and cotinine levels.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Cannabis-using participants reported higher mood (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      =0.006), overall withdrawal (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      =0.009), and sleep-related withdrawal (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt;0.001) symptoms across abstinence compared to controls. Overall withdrawal severity (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      =0.04) and sleep-related withdrawal symptoms (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      =0.02) demonstrated a quadratic trajectory across the monitored abstinence periods, with an increase from baseline and subsequent decreases in symptom severity. No differences of anxiety scores (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      =0.07) or trajectories (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      =0.18) were observed. By study completion, groups did not differ among sleep quality components (all\n                      <jats:italic toggle=\"yes\">p's<\/jats:italic>\n                      &gt;.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>These findings revealed that nontreatment-seeking cannabis-using adolescents and young adults reported heightened total withdrawal symptoms during a 3-week sustained abstinence period relative to controls. Cannabis-using participants demonstrated an increase in withdrawal symptom trajectory during the first week followed by decreased symptoms from weeks 2 to 3, which contrasts with prior linear decreases observed in cannabis-using adolescent and young adults. More mood symptoms were observed in the cannabis-using group even while excluding for comorbid psychopathologies\u2014along with significantly more sleep problems during the abstinence period. Implications include the necessity to provide psychoeducation for recreational, nontreatment-seeking cannabis-using individuals about cannabis withdrawal, mood symptoms, and sleep quality difficulties when cannabis cessation is attempted, to improve likelihood of long-term sustained abstinence.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/can.2021.0074","type":"journal-article","created":{"date-parts":[[2021,10,22]],"date-time":"2021-10-22T16:10:56Z","timestamp":1634919056000},"page":"690-699","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":16,"title":["Assessment of Withdrawal, Mood, and Sleep Inventories After Monitored 3-Week Abstinence in Cannabis-Using Adolescents and Young Adults"],"prefix":"10.1177","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9180-4909","authenticated-orcid":false,"given":"Ryan M.","family":"Sullivan","sequence":"first","affiliation":[{"name":"Department of Psychology, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander L.","family":"Wallace","sequence":"additional","affiliation":[{"name":"Department of Psychology, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth A.","family":"Stinson","sequence":"additional","affiliation":[{"name":"Department of Psychology, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karina V.","family":"Montoto","sequence":"additional","affiliation":[{"name":"Department of Psychology, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine M.","family":"Kaiver","sequence":"additional","affiliation":[{"name":"Department of Psychology, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natasha E.","family":"Wade","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of California, San Diego, San Diego, California, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krista M.","family":"Lisdahl","sequence":"additional","affiliation":[{"name":"Department of Psychology, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,10,12]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"crossref","unstructured":"Schulenberg JE Johnston LD O'Malley PM et al. 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