{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T20:22:05Z","timestamp":1791922925765,"version":"4.3.4"},"reference-count":15,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2023,3,30]],"date-time":"2023-03-30T00:00:00Z","timestamp":1680134400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Cannabis &amp; Cannabinoid Research"],"published-print":{"date-parts":[[2023,4,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>\n                      Cannabidiol (CBD) is one of the main nonpsychoactive components of\n                      <jats:italic toggle=\"yes\">Cannabis sativa<\/jats:italic>\n                      and may represent an alternative treatment for Restless Legs Syndrome\/Willis-Ekbom Disease (RLS\/WED) in patients with Parkinson's disease (PD) and REM (Rapid Eye Movement) sleep behavior disorder (RBD).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>\n                      Our purpose was a\n                      <jats:italic toggle=\"yes\">post hoc<\/jats:italic>\n                      exploratory analysis to evaluate the CBD's efficacy to improve the severity of RLS\/WED symptoms in patients with PD and RBD.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      A\n                      <jats:italic toggle=\"yes\">post hoc<\/jats:italic>\n                      exploratory analysis of a phase II\/III, a parallel, double-blind, placebo-controlled clinical trial was conducted in 18 patients with RLS\/WED and PD plus RBD associated. Six patients were randomized to the CBD group in doses of 75\u2013300\u2009mg, and twelve received placebo capsules. They were followed up for 14 weeks. The primary outcome was the severity of RLS\/WED by Restless Legs Syndrome Rating Scale of the International Restless Legs Syndrome Study Group (IRLSSG).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>CBD showed no difference in relationship to placebo for primary and secondary outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>CBD showed no reduction in the severity of RLS\/WED manifestation in patients with PD and RBD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/can.2021.0158","type":"journal-article","created":{"date-parts":[[2022,6,24]],"date-time":"2022-06-24T16:41:46Z","timestamp":1656088906000},"page":"374-378","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["The Effect of Cannabidiol for Restless Legs Syndrome\/Willis-Ekbom Disease in Parkinson's Disease Patients with REM Sleep Behavior Disorder: A\n                    <i>Post Hoc<\/i>\n                    Exploratory Analysis of Phase 2\/3 Clinical Trial"],"prefix":"10.1177","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6750-6477","authenticated-orcid":false,"given":"Carlos Mauricio Oliveira","family":"de Almeida","sequence":"first","affiliation":[{"name":"School of Health Sciences, State University of Amazonas, Manaus, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuelina Mariana Capellari","family":"Brito","sequence":"additional","affiliation":[{"name":"Division of Neurology, Department of Neuroscience and Sciences of Behavior, Faculty of Medicine, University of S\u00e3o Paulo, Ribeir\u00e3o Preto, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nayanne Beckmann","family":"Bosaipo","sequence":"additional","affiliation":[{"name":"Division of Neurology, Department of Neuroscience and Sciences of Behavior, Faculty of Medicine, University of S\u00e3o Paulo, Ribeir\u00e3o Preto, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela Vieira","family":"Pimentel","sequence":"additional","affiliation":[{"name":"Division of Neurology, Department of Neuroscience and Sciences of Behavior, Faculty of Medicine, University of S\u00e3o Paulo, Ribeir\u00e3o Preto, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manoel Alves","family":"Sobreira-Neto","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, Federal University of Cear\u00e1, Fortaleza, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vitor","family":"Tumas","sequence":"additional","affiliation":[{"name":"Division of Neurology, Department of Neuroscience and Sciences of Behavior, Faculty of Medicine, University of S\u00e3o Paulo, Ribeir\u00e3o Preto, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio Waldo","family":"Zuardi","sequence":"additional","affiliation":[{"name":"Division of Neurology, Department of Neuroscience and Sciences of Behavior, Faculty of Medicine, University of S\u00e3o Paulo, Ribeir\u00e3o Preto, Brazil."},{"name":"National Institute of Science and Technology in Translational Medicine, CNPq\/FAPESP\/CAPES, Ribeir\u00e3o Preto, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose Alexandre de Souza","family":"Crippa","sequence":"additional","affiliation":[{"name":"Division of Neurology, Department of Neuroscience and Sciences of Behavior, Faculty of Medicine, University of S\u00e3o Paulo, Ribeir\u00e3o Preto, Brazil."},{"name":"National Institute of Science and Technology in Translational Medicine, CNPq\/FAPESP\/CAPES, Ribeir\u00e3o Preto, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaime Eduardo Cec\u00edlio","family":"Hallak","sequence":"additional","affiliation":[{"name":"Division of Neurology, Department of Neuroscience and Sciences of Behavior, Faculty of Medicine, University of S\u00e3o Paulo, Ribeir\u00e3o Preto, Brazil."},{"name":"National Institute of Science and Technology in Translational Medicine, CNPq\/FAPESP\/CAPES, Ribeir\u00e3o Preto, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan Luiz","family":"Eckeli","sequence":"additional","affiliation":[{"name":"Division of Neurology, Department of Neuroscience and Sciences of Behavior, Faculty of Medicine, University of S\u00e3o Paulo, Ribeir\u00e3o Preto, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,3,30]]},"reference":[{"key":"e_1_3_5_2_2","first-page":"101","article-title":"Restless legs syndrome: diagnostic criteria, special considerations, and epidemiology","volume":"4","author":"Allen RP","year":"2003","unstructured":"Allen RP, , Picchietti D, , Hening WA, et al. Restless legs syndrome: diagnostic criteria, special considerations, and epidemiology. A report from the restless legs syndrome diagnosis and epidemiology workshop at the National Institutes of Health. Sleep Med. 2003; 4:101\u2013119.","journal-title":"A report from the restless legs syndrome diagnosis and epidemiology workshop at the National Institutes of Health. 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