{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T22:08:21Z","timestamp":1778882901440,"version":"3.51.4"},"reference-count":18,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Cannabis &amp; Cannabinoid Research"],"published-print":{"date-parts":[[2023,8,1]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>Observational studies have reported associations between cannabis use and coronary heart disease. Since diabetes is a coronary heart disease equivalent, we hypothesized that cannabis use would be associated with prevalent angina among individuals with diabetes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This analysis included 1314 participants with diabetes (age 47.4\u00b19.0 years, 49.5% male, 28.3% Caucasians) from the National Health and Nutrition Examination Survey years 2011\u20132018. Cannabis use was self-reported. Prevalent angina was defined by self-reported physician diagnosis. Multivariable logistic regression models were used to examine the association between prevalent angina and cannabis use.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Approximately 3.3% (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      =43) of participants had prevalent angina and 45.7% (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      =601) were ever cannabis users. After adjustment, ever cannabis users did not have significantly increased odds of prevalent angina compared with never users (odds ratio: 3.29, 95% confidence interval [95% CI]: 0.88\u201312.22,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      =0.08). However, those who had used cannabis at least once per month for at least 1 year had greater than fivefold increased odds of prevalent angina (odds ratio: 5.73, 95% CI: 1.26\u201326.04,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      =0.03). Current cannabis users had greater than fivefold increased odds of prevalent angina (odds ratio: 5.35, 95% CI: 1.26\u201322.70,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      =0.03), with a dose\u2013response increase based on level of use. Effect modification was present among those with history of cocaine use (interaction\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      -value &lt;0.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Among individuals with diabetes, cannabis use is associated with prevalent angina with apparent dose response. This finding supports emerging evidence that cannabis may have negative cardiovascular (CV) health effects, and an individualized CV risk assessment should be pursued among those with diabetes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/can.2021.0175","type":"journal-article","created":{"date-parts":[[2022,6,29]],"date-time":"2022-06-29T15:57:36Z","timestamp":1656518256000},"page":"679-683","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Cannabis Use Is Associated with Prevalent Angina in Individuals with Diabetes"],"prefix":"10.1177","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5577-0307","authenticated-orcid":false,"given":"Travis M.","family":"Skipina","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Wake Forest School of Medicine, Winston Salem, North Carolina, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bharathi","family":"Upadhya","sequence":"additional","affiliation":[{"name":"Cardiovascular Medicine Section, Department of Internal Medicine, Wake Forest School of Medicine, Winston Salem, North Carolina, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elsayed Z.","family":"Soliman","sequence":"additional","affiliation":[{"name":"Cardiovascular Medicine Section, Department of Internal Medicine, Wake Forest School of Medicine, Winston Salem, North Carolina, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2023,8,9]]},"reference":[{"key":"e_1_3_3_2_2","unstructured":"Lipari RN Van Horn SL. 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