{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T16:45:57Z","timestamp":1777481157784,"version":"3.51.4"},"reference-count":37,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Cannabis &amp; Cannabinoid Research"],"published-print":{"date-parts":[[2023,10,1]]},"abstract":"<jats:sec>\n                    <jats:title>Rationale:<\/jats:title>\n                    <jats:p>Cannabis use is increasing worldwide, especially among older individuals at risk for chronic ischemic heart disease (IHD). However, little is known about the arrhythmic effects of cannabis use in IHD. Accordingly, we prospectively assessed the relationship between cannabis use, heart rate (HR), and arrhythmias in healthy age-matched controls and subjects with IHD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      Healthy controls (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      =37, 57% men) and subjects with IHD (myocardial infarction \u22653 months ago;\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      =24, 58% men) who used cannabis wore a Zio\n                      <jats:sup>\u00ae<\/jats:sup>\n                      (iRhythm Technologies) monitor for 14 days. Noncannabis using ischemic subjects (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      =35, 51% males) wore Zio monitors for standard clinical indications. Baseline HR was compared with average HR measured for 4\u2009h following consumption and changes in HR and frequency of arrhythmias were correlated with cannabis use.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      In controls, HR increased 20\u2009min (4.99\u00b16.7\u2009bpm,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      =0.08) after use, then declined 4\u2009h following use (\u22127.4\u00b17.7,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt;0.001). Conversely, subjects with IHD showed minimal HR increase (1.6\u00b13.9\u2009bpm) and blunted HR decline (\u22123.4\u00b15.6\u2009bpm,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt;0.001). Supraventricular tachycardia (SVT) (29.7% vs. 58.3%;\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      =0.04) and nonsustained ventricular tachycardia (NSVT) (5.6% vs. 47.8%,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      =0.01) were the most frequently occurring arrhythmias in controls and IHD subjects, respectively. Incidence of SVT decreased as cannabis use increased in both groups. Conversely, NSVT tended to increase with increased use in controls, and was significantly more prevalent in IHD. However, overall arrhythmia burden did not differ between cannabis users and nonusers with IHD.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Our findings demonstrate that chronic cannabis use is associated with only mild HR changes, which are blunted in IHD. In addition, our data suggest that among cannabis users, arrhythmias are more frequent in IHD subjects that in healthy subjects.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/can.2021.0188","type":"journal-article","created":{"date-parts":[[2022,3,30]],"date-time":"2022-03-30T14:09:03Z","timestamp":1648649343000},"page":"867-876","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Arrhythmic Effects of Cannabis in Ischemic Heart Disease"],"prefix":"10.1177","volume":"8","author":[{"given":"Leah","family":"Gillett","sequence":"first","affiliation":[{"name":"Continuing Medical Education, University of Colorado Boulder, Boulder, Colorado, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cecelia","family":"Johnson-Sasso","sequence":"additional","affiliation":[{"name":"Department of Medicine, Northwestern University School of Medicine, Chicago, Illinois, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian","family":"Miller","sequence":"additional","affiliation":[{"name":"Department of Medicine\/Cardiology, University of Colorado, Anschutz Medical Campus, Aurora, Colorado, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Courtney","family":"Shakowski","sequence":"additional","affiliation":[{"name":"Department of Medicine\/Cardiology, University of Colorado, Anschutz Medical Campus, Aurora, Colorado, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2556-8076","authenticated-orcid":false,"given":"Lori A.","family":"Walker","sequence":"additional","affiliation":[{"name":"Department of Medicine\/Cardiology, University of Colorado, Anschutz Medical Campus, Aurora, Colorado, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine","family":"Tompkins","sequence":"additional","affiliation":[{"name":"Department of Medicine\/Cardiology, University of Colorado, Anschutz Medical Campus, Aurora, Colorado, USA."},{"name":"Department of Medicine\/Cardiology, Emory University School of Medicine, Atlanta, Georgia, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2023,10,9]]},"reference":[{"key":"e_1_3_3_2_2","unstructured":"ProCon.org. 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