{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T16:39:37Z","timestamp":1784219977240,"version":"3.55.0"},"reference-count":50,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Cannabis &amp; Cannabinoid Research"],"published-print":{"date-parts":[[2023,12,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To investigate the safety and effectiveness of medical cannabis (MC) in the real-world clinical practice setting.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design:<\/jats:title>\n                    <jats:p>A 4-year prospective noncomparative registry of adult patients who initiated MC for a variety of indications. This paper reports on patients followed for up to 12 months, with interim visits at 3, 6, and 9 months after enrollment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting:<\/jats:title>\n                    <jats:p>Public or private outpatient clinics certified to authorize MC in the province of Quebec, Canada.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants:<\/jats:title>\n                    <jats:p>Overall, 2991 adult (age \u226518 years) patients (mean age 51 years; 50.2% women) were enrolled between May 2015 and October 2018, with the last follow-up ending in May 2019.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interventions\/Exposures:<\/jats:title>\n                    <jats:p>Cannabis products (dried, oil, or other) purchased from a Canadian licensed cannabis producer as authorized by physicians.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main Outcome Measures:<\/jats:title>\n                    <jats:p>The primary outcomes were self-reported pain severity, interference and relief (Brief Pain Inventory [BPI]), symptoms using the Revised Edmonton Symptom Assessment System (ESAS-r) and health-related quality of life dimensions (EQ-5D-5L) at baseline and each follow-up visit. The secondary outcomes were self-reported adverse events (AEs) and characteristics of cannabis treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      All patient-reported outcomes (BPI, ESAS-r, and EQ-5D-5L) showed a statistically significant improvement at 3 months (all\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt;0.01), which was maintained or further improved (for pain interference, tiredness, and well-being) over the remainder of the 12-month follow-up. Results also revealed clinically significant improvements in pain interference and tiredness, anxiety, and well-being from baseline. There were 79 AE reports (77 patients), 16 met the regulatory definition of seriousness, in which only 8 AEs were certainly or probably related to MC.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>MC directed by physicians appears to be safe and effective within 3 months of initiation for a variety of medical indications.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/can.2022.0041","type":"journal-article","created":{"date-parts":[[2022,12,29]],"date-time":"2022-12-29T09:10:46Z","timestamp":1672305046000},"page":"1106-1116","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":15,"title":["The Quebec Cannabis Registry: Investigating the Safety and Effectiveness of Medical Cannabis"],"prefix":"10.1177","volume":"8","author":[{"given":"Antonio","family":"Vigano","sequence":"first","affiliation":[{"name":"Medical Cannabis Program in Oncology, Cedars Cancer Center, McGill University Health Centre, Montreal, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yola","family":"Moride","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, University of Montreal, Montreal, Canada."},{"name":"Rutgers The State University of New Jersey, Center for Pharmacoepidemiology and Treatment Science, New Brunswick, New Jersey, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3475-8915","authenticated-orcid":false,"given":"Yasmina","family":"Hachem","sequence":"additional","affiliation":[{"name":"Medical Cannabis Program in Oncology, Cedars Cancer Center, McGill University Health Centre, Montreal, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Canac-Marquis","sequence":"additional","affiliation":[{"name":"Research Institute of the McGill University Health Centre, Montreal, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rihab","family":"Gamaoun","sequence":"additional","affiliation":[{"name":"Medical Cannabis Program in Oncology, Cedars Cancer Center, McGill University Health Centre, Montreal, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3628-5197","authenticated-orcid":false,"given":"Maja","family":"Kalaba","sequence":"additional","affiliation":[{"name":"Canopy Growth Corporation, Smiths Falls, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc O.","family":"Martel","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry &amp; Department of Anesthesia, McGill University, Montreal, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordi","family":"Perez","sequence":"additional","affiliation":[{"name":"Alan Edwards Pain Management Unit, McGill University Health Centre, Montreal, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9e","family":"N\u00e9ron","sequence":"additional","affiliation":[{"name":"McGill University Health Centre, Montreal, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Beaulieu","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology &amp; Pain Medicine, Universit\u00e9 de Montr\u00e9al Facult\u00e9 de Medecine, Montreal, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Desroches","sequence":"additional","affiliation":[{"name":"D\u00e9partement de Pharmacologie, Universit\u00e9 de Montr\u00e9al, Montreal, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Ware","sequence":"additional","affiliation":[{"name":"Department of Family Medicine, McGil University, Montreal, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,12,4]]},"reference":[{"key":"e_1_3_8_2_2","unstructured":"Government of Canada. 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