{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T16:48:05Z","timestamp":1777481285253,"version":"3.51.4"},"reference-count":39,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2023,2,17]],"date-time":"2023-02-17T00:00:00Z","timestamp":1676592000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Cannabis &amp; Cannabinoid Research"],"published-print":{"date-parts":[[2024,4,1]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>\n                      \u0394\n                      <jats:sup>9<\/jats:sup>\n                      -Tetrahydrocannabinol (THC) acts as an agonist at cannabinoid receptors. Its chronic intake affects many behaviors, including cognitive processes. The aims of this study in rats are to assess the chronic effects of THC on impulsivity and on regional brain glucose uptake.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>\n                      For the determination of \u201cwaiting impulsivity,\u201d a total of 20 male Lister Hooded rats were trained to perform a reaction time task, followed by a baseline test of impulsivity and baseline glucose uptake measurements with [\n                      <jats:sup>18<\/jats:sup>\n                      F]-fluoro-2-deoxy-D-glucose and positron emission tomography (PET). Then, 10 rats each received 3\u2009mg\/kg THC or vehicle injected intraperitoneally daily for 21 days. Subsequently, a second behavioral test and PET measurements were performed, and blood THC concentrations were determined. Analyses of variance of brain regions of the impulsivity network with the parameter \u201cstandardized uptake value\u201d regarding glucose uptake and correlation analyses of the collected parameters were carried out.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion:<\/jats:title>\n                    <jats:p>\n                      After chronic THC treatment, decreased glucose uptake (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      -values &lt;0.05) was found in cingulate cortex, hippocampus, amygdala, thalamus, and cerebellar cortex, as compared with vehicle-treated rats. The number of correct no-go responses (increased waiting time) significantly increased (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt;0.05) in THC-treated rats. Furthermore, correct no-go responses correlated positively and strongly with the THC blood concentrations (Spearman's\n                      <jats:italic toggle=\"yes\">\u03c1<\/jats:italic>\n                      =0.79,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt;0.01).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>These findings reflect a specific reduction in impulsive behavior after chronic THC treatment, showing a functionally relevant influence of THC on \u201cwaiting impulsivity\u201d with reduced selective glucose uptake at the same time.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/can.2022.0268","type":"journal-article","created":{"date-parts":[[2023,2,17]],"date-time":"2023-02-17T11:46:52Z","timestamp":1676634412000},"page":"612-621","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Chronic Administration of \u0394\n                    <sup>9<\/sup>\n                    -Tetrahydrocannabinol Alters Brain Glucose Uptake and Improves Waiting Impulsivity in the Rat"],"prefix":"10.1177","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1148-7964","authenticated-orcid":false,"given":"Isabelle","family":"Miederer","sequence":"first","affiliation":[{"name":"Department of Nuclear Medicine, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulrich","family":"Schmitt","sequence":"additional","affiliation":[{"name":"Leibniz Institute for Resilience Research (LIR), Mainz, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicole","family":"Bausbacher","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00f6rg","family":"R\u00f6hrich","sequence":"additional","affiliation":[{"name":"Institute of Legal Medicine, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philipp","family":"Mildenberger","sequence":"additional","affiliation":[{"name":"Institute for Medical Biostatistics, Epidemiology and Informatics, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beat","family":"Lutz","sequence":"additional","affiliation":[{"name":"Leibniz Institute for Resilience Research (LIR), Mainz, Germany."},{"name":"Institute of Physiological Chemistry, and University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oliver","family":"T\u00fcscher","sequence":"additional","affiliation":[{"name":"Leibniz Institute for Resilience Research (LIR), Mainz, Germany."},{"name":"Department of Psychiatry and Psychotherapy, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mathias","family":"Schreckenberger","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2023,2,17]]},"reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2017.02.011"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0925-4927(91)90030-T"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/YCO.0b013e3280ba4989"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrn.2017.8"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2010.08.007"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1177\/1550059421993340"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2008.09.021"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(01)01212-2"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-006-0121-7"},{"key":"e_1_3_5_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/syn.10089"},{"key":"e_1_3_5_12_2","unstructured":"Widmark E. 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