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The placenta supplies oxygen and nutrients to the fetus, and alterations in placental development can lead to FGR. While there has been some investigation into the effects of \u0394\n                      <jats:sup>9<\/jats:sup>\n                      -THC, there has been limited investigation into the impacts of\n                      <jats:italic toggle=\"yes\">in utero<\/jats:italic>\n                      gestational CBD exposure on the placenta.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This study used histological and transcriptomic analysis of embryonic day (E)19.5 rat placentas from vehicle and CBD (3\u2009mg\/kg intraperitoneal injection) exposed pregnancies (E6.5-18.5).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>The study revealed that pups from CBD-exposed pregnancies were 10% smaller, with the placentae displaying a decreased fetal blood space perimeter-to-area ratio. The transcriptomic analysis supported compromised angiogenesis and blood vessel formation with downregulated biological processes, including tube morphogenesis, angiogenesis, blood vessel morphogenesis, blood vessel development and vasculature development. Further, the CBD-exposed placentas displayed changed expression of glucose transporters (decreased GLUT1 and GR expression and increased GLUT3 expression). Transcriptomic analysis further revealed upregulated biological processes associated with metabolism. Finally, histological and transcriptomic analysis revealed altered cell populations within the placenta, specifically to syncytiotrophoblast layer II and endothelial cells.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Together these results suggest that the structural changes in CDB-exposed placentae, including the altered expression of nutrient transporters and the changes to the placental fetal vasculature, may underlie the reduced fetal growth.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/can.2023.0166","type":"journal-article","created":{"date-parts":[[2024,2,16]],"date-time":"2024-02-16T15:41:25Z","timestamp":1708098085000},"page":"766-780","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":20,"title":["Cannabidiol Exposure During Rat Pregnancy Leads to Labyrinth-Specific Vascular Defects in the Placenta and Reduced Fetal Growth"],"prefix":"10.1177","volume":"9","author":[{"given":"Sofia","family":"Allen","sequence":"first","affiliation":[{"name":"Department of Biomedical and Molecular Sciences, Queen's University, Kingston, Ontario, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bryony V.","family":"Natale","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Queen's University, Kingston, Ontario, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexis O.","family":"Ejeckam","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Molecular Sciences, Queen's University, Kingston, Ontario, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kendrick","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology, The University of Western Ontario, London, Ontario, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5445-273X","authenticated-orcid":false,"given":"Daniel B.","family":"Hardy","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology, The University of Western Ontario, London, Ontario, Canada."},{"name":"The Children's Health Research Institute, The University of Western Ontario, London, Ontario, Canada."},{"name":"Lawson Health Research Institute, The University of Western Ontario, London, Ontario, Canada."},{"name":"Department of Obstetrics and Gynaecology, The University of Western Ontario, London, Ontario, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8365-455X","authenticated-orcid":false,"given":"David R.C.","family":"Natale","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Molecular Sciences, Queen's University, Kingston, Ontario, Canada."},{"name":"Department of Obstetrics and Gynaecology, Queen's University, Kingston, Ontario, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,6,18]]},"reference":[{"key":"e_1_3_6_2_2","doi-asserted-by":"publisher","DOI":"10.1177\/2045125312457586"},{"key":"e_1_3_6_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2017.198"},{"key":"e_1_3_6_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2019.7982"},{"key":"e_1_3_6_5_2","doi-asserted-by":"publisher","DOI":"10.1159\/000320550"},{"key":"e_1_3_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2010.01.007"},{"key":"e_1_3_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2015.03.021"},{"key":"e_1_3_6_8_2","doi-asserted-by":"publisher","DOI":"10.4172\/2155-6105.1000135"},{"key":"e_1_3_6_9_2","doi-asserted-by":"publisher","DOI":"10.17269\/s41997-018-0148-0"},{"key":"e_1_3_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2013.09.008"},{"key":"e_1_3_6_11_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2017.17225"},{"key":"e_1_3_6_12_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0021932017000062"},{"key":"e_1_3_6_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11916-020-00872-w"},{"key":"e_1_3_6_14_2","doi-asserted-by":"publisher","DOI":"10.31887\/DCNS.2007.9.4\/nkogan"},{"key":"e_1_3_6_15_2","unstructured":"National Academies of Sciences Engineering and Medicine; Health and Medicine Division; Board on Population Health and Public Health Practice; Committee on the Health Effects of Marijuana: An Evidence Review and Research Agenda. 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