{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:09:29Z","timestamp":1787008169575,"version":"build-2736575974"},"reference-count":32,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Cannabis &amp; Cannabinoid Research"],"published-print":{"date-parts":[[2024,10,1]]},"abstract":"<jats:p>\n                    To evaluate the anticaries and antigingivitis properties of cannabinoid-containing oral health products. A systematic research strategy was employed. Specific search terms were used, including \u201cCannabinoids AND dental caries,\u201d \u201cCannabinoids AND oral health,\u201d \u201cCannabinoids AND dental plaque,\u201d \u201cCannabinoids AND gingivitis AND periodontitis,\u201d \u201cCannabinoids AND S. mutans,\u201d \u201cCannabidiol AND oral health,\u201d and \u201cCannabidiol AND oral biofilm.\u201d The search was conducted in PubMed, Cochrane, and EBSCO Host databases. The search yielded a total of 73 articles, out of which 15 articles (20.5%) were relevant to the scope of this systematic review. Among the relevant articles, only eight (10.9%) directly addressed the research question. The findings from these articles suggest that cannabinoids have the potential to reduce the metabolism of cariogenic bacteria, specifically\n                    <jats:italic toggle=\"yes\">Streptococcus mutans<\/jats:italic>\n                    , and decrease the number of bacterial colonies in dental plaque.\n                    <jats:italic toggle=\"yes\">In vitro<\/jats:italic>\n                    studies also demonstrated a significant inhibitory effect of cannabinoids on oral biofilms and create a considerable inhibitory zone of growth when investigated on oral biofilms\n                    <jats:italic toggle=\"yes\">in vitro<\/jats:italic>\n                    . Furthermore, CBD exhibited antibacterial properties against\n                    <jats:italic toggle=\"yes\">Porphyromonas gingivalis<\/jats:italic>\n                    , a primary pathogen associated with periodontal disease. The current review shows insufficient data to conclude on the anticaries and antigingivitis effects of cannabinoids. Despite extensive research on their systemic therapeutic benefits, their oral health impact remains underexplored, lacking clinical trials and primary research.\n                  <\/jats:p>","DOI":"10.1089\/can.2023.0206","type":"journal-article","created":{"date-parts":[[2024,4,9]],"date-time":"2024-04-09T17:01:57Z","timestamp":1712682117000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Anticaries and Antigingivitis Properties of Cannabinoid-Containing Oral Health Products: A Review"],"prefix":"10.1177","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3763-8772","authenticated-orcid":false,"given":"Jila","family":"Torabi","sequence":"first","affiliation":[{"name":"West Coast University, Dental Hygiene Program, Anaheim, CA, USA."},{"name":"Unidade de Investiga\u00e7\u00e3o em Ci\u00eancias Orais e Biom\u00e9dicas (UICOB), RHODes\u2014Dental Hygienists for Science, Faculdade de Medicina Dent\u00e1ria, Universidade de Lisboa, Lisboa, Portugal."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1092-7825","authenticated-orcid":false,"given":"Henrique","family":"Luis","sequence":"additional","affiliation":[{"name":"Unidade de Investiga\u00e7\u00e3o em Ci\u00eancias Orais e Biom\u00e9dicas (UICOB), RHODes\u2014Dental Hygienists for Science, Faculdade de Medicina Dent\u00e1ria, Universidade de Lisboa, Lisboa, Portugal."},{"name":"Center for Innovative Care and Health Technology (ciTechcare), Polytechnic of Leiria, Leiria, Portugal."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Hurlbutt","sequence":"additional","affiliation":[{"name":"West Coast University, Dental Hygiene Program, Anaheim, CA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,10,7]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)31146-8"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1177\/0022034517693567"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1159\/000503309"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.01403"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12906-020-2812-1"},{"issue":"2","key":"e_1_3_4_7_2","first-page":"107","article-title":"Diagnosis and prevention strategies for dental caries","volume":"3","author":"Lee Y","year":"2013","unstructured":"Lee Y. 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