{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T21:20:43Z","timestamp":1790630443429,"version":"4.1.0"},"reference-count":44,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2024,2,13]],"date-time":"2024-02-13T00:00:00Z","timestamp":1707782400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Cannabis &amp; Cannabinoid Research"],"published-print":{"date-parts":[[2025,2,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background and Aims:<\/jats:title>\n                    <jats:p>This investigation examined the association of pancreatitis and pancreatitis-related pain with serum levels of two endocannabinoid molecules such as anandamide (AEA) and 2-arachidonoylglycerol (2-AG) and two paracannabinoid molecules such as oleoylethanolamide (OEA) and palmitoylethanolamide (PEA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      A case\u2013control study was conducted within the Prospective Evaluation of Chronic Pancreatitis for Epidemiological and Translational Studies, including participants with no pancreas disease (\n                      <jats:italic toggle=\"yes\">N<\/jats:italic>\n                      = 56), chronic abdominal pain of suspected pancreatic origin or indeterminate chronic pancreatitis (CP) (\n                      <jats:italic toggle=\"yes\">N<\/jats:italic>\n                      = 22), acute pancreatitis (\n                      <jats:italic toggle=\"yes\">N<\/jats:italic>\n                      = 33), recurrent acute pancreatitis (\n                      <jats:italic toggle=\"yes\">N<\/jats:italic>\n                      = 57), and definite CP (\n                      <jats:italic toggle=\"yes\">N<\/jats:italic>\n                      = 63).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Circulating AEA concentrations were higher in women than in men (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = 0.0499), and PEA concentrations were higher in obese participants than those who were underweight\/normal or overweight (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = 0.003). Asymptomatic controls with no pancreatic disease had significantly (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = 0.03) lower concentrations of AEA compared with all disease groups combined. The highest concentrations of AEA were observed in participants with acute pancreatitis, followed by those with recurrent acute pancreatitis, chronic abdominal pain\/indeterminant CP, and definite CP. Participants with pancreatitis reporting abdominal pain in the past year had significantly (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = 0.04) higher concentrations of AEA compared with asymptomatic controls. Levels of 2-AG were significantly lower (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = 0.02) among participants reporting abdominal pain in the past week, and pain intensity was inversely associated with concentrations of 2-AG and OEA.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Endocannabinoid levels may be associated with stage of pancreatitis, perhaps through activation of the CB1 receptor. Validation of our findings would support the investigation of novel therapeutics, including cannabinoid receptor-1 antagonists, in this patient population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/can.2024.0079","type":"journal-article","created":{"date-parts":[[2024,9,18]],"date-time":"2024-09-18T04:36:21Z","timestamp":1726634181000},"page":"60-70","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Association of Serum Endocannabinoid Levels with Pancreatitis and Pancreatitis-Related Pain"],"prefix":"10.1177","volume":"10","author":[{"given":"Marc T.","family":"Goodman","sequence":"first","affiliation":[{"name":"Prevention and Control Program, Cancer Center, Cedars-Sinai Medical Center, Los Angeles, California, USA.."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Lombardi","sequence":"additional","affiliation":[{"name":"Prevention and Control Program, Cancer Center, Cedars-Sinai Medical Center, Los Angeles, California, USA.."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7075-5669","authenticated-orcid":false,"given":"Alexa","family":"Torrens","sequence":"additional","affiliation":[{"name":"Department and Anatomy and Neurobiology, University of California, Irvine, California, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Bresee","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Bioinformatics Research Center, Cedars-Sinai Medical Center, Los Angeles, California, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jami L.","family":"Saloman","sequence":"additional","affiliation":[{"name":"Center for Pain Research, Division of Gastroenterology, Hepatology and Nutrition, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunlong","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William E.","family":"Fisher","sequence":"additional","affiliation":[{"name":"Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evan L.","family":"Fogel","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Indiana University School of Medicine, Indianapolis, Indiana, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher E.","family":"Forsmark","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology, and Nutrition, University of Florida, Gainesville, Florida, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darwin L.","family":"Conwell","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Kentucky College of Medicine, Lexington, Kentucky, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phil A.","family":"Hart","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology, &amp; Nutrition, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter G.","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Gastroenterology and Hepatology, Stanford University Medical Center, Stanford, California, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4839-3021","authenticated-orcid":false,"given":"Mark","family":"Topazian","sequence":"additional","affiliation":[{"name":"Mayo Clinic, Rochester, Minnesota, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santhi S.","family":"Vege","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen K.","family":"Van Den Eeden","sequence":"additional","affiliation":[{"name":"Division of Research, Kaiser Permanente Northern California, Oakland, California, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melena D.","family":"Bellin","sequence":"additional","affiliation":[{"name":"Division of Pediatric Endocrinology, Department of Pediatrics, University of Minnesota Medical School, Minneapolis, Minnesota, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dana K.","family":"Andersen","sequence":"additional","affiliation":[{"name":"Division of Digestive Diseases and Nutrition, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose","family":"Serrano","sequence":"additional","affiliation":[{"name":"Division of Digestive Diseases and Nutrition, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dhiraj","family":"Yadav","sequence":"additional","affiliation":[{"name":"Department of Medicine Division of Gastroenterology, Hepatology &amp; 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