{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T11:51:28Z","timestamp":1784893888754,"version":"3.55.0"},"reference-count":68,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2025,5,12]],"date-time":"2025-05-12T00:00:00Z","timestamp":1747008000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Cannabis &amp; Cannabinoid Research"],"published-print":{"date-parts":[[2025,10,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>\n                      Epilepsy is a neurological chronic disorder that affects about 70 million people worldwide.\n                      <jats:italic toggle=\"yes\">Status epilepticus<\/jats:italic>\n                      (SE) are neural disturbances that cause intense glutamatergic excitatory discharges that modulate changes in normal brain physiological activity. Cannabidiol (CBD) is the main nonpsychomimetic compound present in\n                      <jats:italic toggle=\"yes\">Cannabis sativa<\/jats:italic>\n                      and exhibits a wide spectrum of neuroprotective properties. The use of zebrafish (\n                      <jats:italic toggle=\"yes\">Danio rerio<\/jats:italic>\n                      ) is regarded as an important alternative animal model for studies on seizures, as it has neuronal mechanisms similar to humans.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>This study aims to evaluate the effects of CBD on SE induced by kainic acid (KA) in zebrafish.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      Animals received CBD (5, 10, or 40 mg\u00b7L\n                      <jats:sup>\u22121<\/jats:sup>\n                      tank water) for 24 h followed by KA administration (5 mg\/kg intraperitoneally). The convulsive pattern of alterations was then assessed. After 12 h, cerebral glutamate transport and oxidative stress were also verified.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      CBD at 5 and 40 mg\u00b7L\n                      <jats:sup>\u22121<\/jats:sup>\n                      induced a significant decrease in the seizure intensity (26.1% and 29.9%) and an increase in the latency to reach SE (from 10.71 min to 17.5 and 25 min), respectively. In addition, CBD administration (40 mg\u00b7L\n                      <jats:sup>\u22121<\/jats:sup>\n                      ) attenuated the decrease in cerebral glutamate transport following 12 h KA-induced seizure. The KA-induced seizure was also able to alter the oxidative stress parameters 2\u2032,7\u2032-dichlorofluorescin, and catalase activity. However, CBD (40 mg\u00b7L\n                      <jats:sup>\u22121<\/jats:sup>\n                      ) did not influence these markers. The present study indicates that CBD promotes a neuroprotective response against the epileptic profile in zebrafish. These findings contribute to the understanding of the influence of CBD on the modulation of excitatory\/inhibitory disruption on zebrafish seizure.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/can.2024.0189","type":"journal-article","created":{"date-parts":[[2025,5,12]],"date-time":"2025-05-12T13:16:37Z","timestamp":1747055797000},"page":"609-620","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Cannabidiol Pretreatment Reduces Status Epilepticus and Glutamate Uptake Induced by Kainic Acid in Adult Zebrafish"],"prefix":"10.1177","volume":"10","author":[{"given":"Karolyne","family":"de Pieri Pickler","sequence":"first","affiliation":[{"name":"Translational Psychiatry Laboratory, Graduate Program in Health Sciences, University of Southern Santa Catarina (UNESC), Crici\u00fama, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Caroline Salvador","family":"de Farias","sequence":"additional","affiliation":[{"name":"Translational Psychiatry Laboratory, Graduate Program in Health Sciences, University of Southern Santa Catarina (UNESC), Crici\u00fama, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guilherme","family":"Lodetti","sequence":"additional","affiliation":[{"name":"Translational Psychiatry Laboratory, Graduate Program in Health Sciences, University of Southern Santa Catarina (UNESC), Crici\u00fama, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrique Teza","family":"Bernardo","sequence":"additional","affiliation":[{"name":"Translational Psychiatry Laboratory, Graduate Program in Health Sciences, University of Southern Santa Catarina (UNESC), Crici\u00fama, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samira Leila","family":"Baldin","sequence":"additional","affiliation":[{"name":"Translational Psychiatry Laboratory, Graduate Program in Health Sciences, University of Southern Santa Catarina (UNESC), Crici\u00fama, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo Ronconi","family":"Dondossola","sequence":"additional","affiliation":[{"name":"Translational Psychiatry Laboratory, Graduate Program in Health Sciences, University of Southern Santa Catarina (UNESC), Crici\u00fama, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaime Eduardo","family":"Hallak","sequence":"additional","affiliation":[{"name":"Department of Neuroscience and Behavior, Ribeir\u00e3o Preto Medical School, University of S\u00e3o Paulo, Ribeir\u00e3o Preto, Brazil."},{"name":"National Institute for Science and Technology Translational in Medicine (INCT TM), CNPq\/FAPESP\/CAPES, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9520-6746","authenticated-orcid":false,"given":"Jos\u00e9 Alexandre","family":"Crippa","sequence":"additional","affiliation":[{"name":"Department of Neuroscience and Behavior, Ribeir\u00e3o Preto Medical School, University of S\u00e3o Paulo, Ribeir\u00e3o Preto, Brazil."},{"name":"National Institute for Science and Technology Translational in Medicine (INCT TM), CNPq\/FAPESP\/CAPES, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Henrique","family":"Cararo","sequence":"additional","affiliation":[{"name":"Translational Psychiatry Laboratory, Graduate Program in Health Sciences, University of Southern Santa Catarina (UNESC), Crici\u00fama, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josiane","family":"Budni","sequence":"additional","affiliation":[{"name":"Experimental Neurology Laboratory, Graduate Program in Health Sciences, University of Southern Santa Catarina (UNESC), Crici\u00fama, 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