{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T09:58:03Z","timestamp":1792144683105,"version":"4.4.0"},"reference-count":21,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2011,6,1]],"date-time":"2011-06-01T00:00:00Z","timestamp":1306886400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Child and Adolescent Psychopharmacology"],"published-print":{"date-parts":[[2011,6]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>The objective of this study was to explore whether the addition of olanzapine versus placebo increases weight gain and improves psychological symptoms in adolescents with anorexia nervosa-restricting type who are participating in a comprehensive eating disorders treatment program.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Twenty underweight females participated in this 10-week, double-blind, placebo-controlled pilot study of olanzapine. The primary efficacy measure was change in percentage of median body weight measured at baseline and weeks 5 and 10. Secondary efficacy measures included clinician-rated and self-reported measures of psychological functioning measured at 2-week intervals and eating disorder symptoms measured at baseline and weeks 5 and 10 as well as laboratory assessments (including indirect calorimetry), which were also performed at baseline and weeks 5 and 10. A mixed models approach to repeated measures analysis of variance was utilized to detect any treatment-by-time interaction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Fifteen of 20 enrolled females (median age, 17.1 years; range, 12.3\u201321.8 years; mean body mass index, 16.3) completed this 10-week pilot study. Change in % median body weight did not differ between the treatment groups at midpoint or end of study. Both groups gained weight at a similar rate and had similar improvements in eating attitudes and behaviors, psychological functioning, and resting energy expenditure. A trend of increasing fasting glucose and insulin levels was found only in the olanzapine group at week 10.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>These preliminary findings do not support a role for adjunctive olanzapine for underweight adolescent females with anorexia nervosa-restricting type who are receiving standard care in an eating disorder treatment program (clinical trials.gov; no. NCT00592930).<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/cap.2010.0139","type":"journal-article","created":{"date-parts":[[2011,6,10]],"date-time":"2011-06-10T15:10:35Z","timestamp":1307718635000},"page":"207-212","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":131,"title":["A Placebo-Controlled Pilot Study of Adjunctive Olanzapine for Adolescents with Anorexia Nervosa"],"prefix":"10.1177","volume":"21","author":[{"given":"Vivian","family":"Kafantaris","sequence":"first","affiliation":[{"name":"The Zucker Hillside Hospital"},{"name":"Hofstra North Shore-LIJ School of Medicine at Hofstra University, Hempstead, New York."},{"name":"The Feinstein Institute for Medical Research"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen","family":"Leigh","sequence":"additional","affiliation":[{"name":"Medford, Massachusetts."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stanley","family":"Hertz","sequence":"additional","affiliation":[{"name":"Private Practice, Roslyn, New York."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alison","family":"Berest","sequence":"additional","affiliation":[{"name":"The Zucker Hillside Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janet","family":"Schebendach","sequence":"additional","affiliation":[{"name":"New York State Psychiatric Institute"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendy Meyer","family":"Sterling","sequence":"additional","affiliation":[{"name":"Cohen Children's Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ema","family":"Saito","sequence":"additional","affiliation":[{"name":"The Zucker Hillside Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzanne","family":"Sunday","sequence":"additional","affiliation":[{"name":"Hofstra North Shore-LIJ School of Medicine at Hofstra University, Hempstead, New York."},{"name":"The Feinstein Institute for Medical Research"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudine","family":"Higdon","sequence":"additional","affiliation":[{"name":"The Zucker Hillside Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neville H.","family":"Golden","sequence":"additional","affiliation":[{"name":"Stanford University School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anil K.","family":"Malhotra","sequence":"additional","affiliation":[{"name":"The Zucker Hillside Hospital"},{"name":"Hofstra North Shore-LIJ School of Medicine at Hofstra University, Hempstead, New York."},{"name":"The Feinstein Institute for Medical Research"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2011,6,1]]},"reference":[{"key":"e_1_3_3_2_1","volume-title":"Diagnostic and Statistical Manual of Mental Disorders","author":"American Psychiatric Association","year":"1994","unstructured":"American Psychiatric Association. 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