{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T07:07:03Z","timestamp":1779692823243,"version":"3.53.1"},"reference-count":60,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2017,2,1]],"date-time":"2017-02-01T00:00:00Z","timestamp":1485907200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Child and Adolescent Psychopharmacology"],"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>Emotional dysregulation is an important element in the pathophysiology of childhood anxiety disorders and can distinguish anxious subjects from controls. Treatment with selective serotonin inhibitors (SSRIs) has been found to lessen anxiety, but its effects on emotional reactivity and regulation are less documented. The aim of the study was to prospectively assess changes in emotional reactivity and regulation in response to citalopram in children and adolescents with anxiety disorders, with special focus on the mechanism of reappraisal.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      The sample included 70 children and adolescents (38 boys, 32 girls) 10\u201317 years of age, divided into three groups: Those with anxiety disorder treated with citalopram for 8 weeks (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u200935); untreated subjects with anxiety disorder on the waiting list for cognitive behavioral therapy (CBT) (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u200915); and subjects without anxiety disorder (controls) (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u200920). Emotional reactivity and regulation (i.e., reappraisal), were assessed at baseline and after 8 weeks (follow-up) with validated computer-based instruments, Reactivity and Regulation-Situations (REAR-S) and Reactivity and Regulation-Images (REAR-I).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Citalopram-treated subjects showed significantly greater improvement in reappraisal ability than CBT-waitlisted subjects. Improvement in the ability to reappraise threatening images correlated significantly with the decrease in anxiety. There was a decrease in negative emotional reactivity between assessments, which was positively correlated with clinical improvement. Higher intensity of baseline reactivity (on the REAR-S) predicted more severe symptoms at follow-up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Citalopram therapy improves reappraisal ability in children and adolescents with anxiety. However, the improvement in other examined emotional reactivity indices occurred in both medicated and waitlisted groups. It is possible that these findings may have implications for understanding the pathophysiology of anxiety in children and adolescents.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/cap.2015.0067","type":"journal-article","created":{"date-parts":[[2016,1,15]],"date-time":"2016-01-15T17:17:53Z","timestamp":1452878273000},"page":"43-51","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Emotional Reactivity and Regulation Following Citalopram Therapy in Children and Adolescents with Anxiety Disorders"],"prefix":"10.1177","volume":"27","author":[{"given":"Tal","family":"Carthy","sequence":"first","affiliation":[{"name":"Schneider Children's Medical Center of Israel","place":["Israel"]},{"name":"Interdisciplinary Center","place":["Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noa","family":"Benaroya-Milshtein","sequence":"additional","affiliation":[{"name":"Schneider Children's Medical Center of Israel","place":["Israel"]},{"name":"Tel Aviv University","place":["Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Avi","family":"Valevski","sequence":"additional","affiliation":[{"name":"Tel Aviv University","place":["Israel"]},{"name":"Tel Aviv University","place":["Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan","family":"Apter","sequence":"additional","affiliation":[{"name":"Schneider Children's Medical Center of Israel","place":["Israel"]},{"name":"Tel Aviv University","place":["Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2017,2,1]]},"reference":[{"key":"e_1_3_3_2_1","unstructured":"American Psychiatric Association: Diagnostic and Statistical Manual of Mental Disorders 4th ed. 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