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In a previous transmission disequilibrium study in which 75 complete trios were included, single-nucleotide polymorphisms (SNPs) in serotoninergic and GABAergic genes were associated with early-onset OCD. Our aim was to assess those findings in an extended collection of early-onset OCD trios.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      A transmission disequilibrium test for SNPs in\n                      <jats:italic toggle=\"yes\">HTR1B<\/jats:italic>\n                      (rs2000292),\n                      <jats:italic toggle=\"yes\">SLC18A1<\/jats:italic>\n                      (rs6586896),\n                      <jats:italic toggle=\"yes\">GAD1<\/jats:italic>\n                      (rs3791860), and\n                      <jats:italic toggle=\"yes\">GAD2<\/jats:italic>\n                      (rs8190748) was performed in a total of 101 early-onset OCD trios, from which 26 trios were newly recruited for the purpose of the present analysis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      All the SNPs were overtransmitted from parents to OCD probands (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.012, significant after Bonferroni correction).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>These results are consistent with the previous findings and constitute more evidence of the role of genetic factors related to serotoninergic and GABAergic pathways in the pathophysiology of early-onset OCD.<\/jats:p>\n                  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