{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T20:11:12Z","timestamp":1777493472883,"version":"3.51.4"},"reference-count":49,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2019,1,25]],"date-time":"2019-01-25T00:00:00Z","timestamp":1548374400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Child and Adolescent Psychopharmacology"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>Methylphenidate and atomoxetine are efficacious in reducing core symptoms of attention-deficit\/hyperactivity disorder (ADHD), but little is known about their efficacy in improving emotional\/behavioral problems among youths with ADHD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      One hundred sixty drug-na\u00efve youths with DSM-IV-defined ADHD, aged 7\u201316 years, were recruited and randomly assigned to osmotic-release oral system methylphenidate (OROS-methylphenidate;\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u200980) and atomoxetine (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u200980) in a 24-week, open-label, head-to-head clinical trial. The primary efficacy measure was parent-reported Child Behavior Checklist (CBCL), and the secondary efficacy measures included Youth Self Report (YSR) and Strengths and Difficulties Questionnaire (SDQ), which was based on the ratings of parents, teachers, and subjects.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>For CBCL, both methylphenidate and atomoxetine groups showed significant improvement in all scores at weeks 8 and 24 except Somatic Complaints in the atomoxetine group. For SDQ, both treatment groups showed significant improvements in the Hyperactive and Conduct subscales for parent ratings, and the Externalizing subscale for teacher ratings at week 24. Methylphenidate was associated with greater improvements in Aggressive Behavior and Somatic Complaints of CBCL and in Conduct subscale of self-reported SDQ at week 24 compared with atomoxetine.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Our findings provide evidence to support that both methylphenidate and atomoxetine were effective in improving a wide range of emotional\/behavioral problems in youths with ADHD after 24 weeks of treatment, with greater improvement in aggressive behavior, somatic complaints, and conduct problems in the methylphenidate group.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/cap.2018.0076","type":"journal-article","created":{"date-parts":[[2018,11,20]],"date-time":"2018-11-20T10:33:39Z","timestamp":1542710019000},"page":"9-19","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":15,"title":["Comparative Efficacy of Methylphenidate and Atomoxetine on Emotional and Behavioral Problems in Youths with Attention-Deficit\/Hyperactivity Disorder"],"prefix":"10.1177","volume":"29","author":[{"given":"Hsien-Hsueh","family":"Shih","sequence":"first","affiliation":[{"name":"National Taiwan University Hospital","place":["Taiwan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chi-Yung","family":"Shang","sequence":"additional","affiliation":[{"name":"National Taiwan University Hospital","place":["Taiwan"]},{"name":"National Taiwan University","place":["Taiwan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan Shur-Fen","family":"Gau","sequence":"additional","affiliation":[{"name":"National Taiwan University Hospital","place":["Taiwan"]},{"name":"National Taiwan University","place":["Taiwan"]},{"name":"National Taiwan University","place":["Taiwan"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2019,1,25]]},"reference":[{"key":"e_1_3_4_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/15374416.2011.533416"},{"key":"e_1_3_4_3_1","doi-asserted-by":"publisher","DOI":"10.1037\/0022-006X.69.4.699"},{"key":"e_1_3_4_4_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2006-1880"},{"key":"e_1_3_4_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-006-0565-2"},{"key":"e_1_3_4_6_1","first-page":"508","article-title":"Are stimulants effective in the treatment of executive function deficits?","volume":"21","author":"Biederman J","year":"2011","unstructured":"Biederman J, , Mick E, , Fried R, , Wilner N, , Spencer TJ, , Faraone SV: Are stimulants effective in the treatment of executive function deficits?. 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