{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T20:15:50Z","timestamp":1777493750956,"version":"3.51.4"},"reference-count":53,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Child and Adolescent Psychopharmacology"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>A preliminary investigation of the impact of a serotonergic agent (fluoxetine) on symptom profile and neural response in youths with disruptive behavior disorders (DBDs) and a history of trauma exposure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      There were three participant groups: (i) Youths with DBDs and trauma exposure who received fluoxetine treatment for 8 weeks (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u200911); (ii) A matched group of youths with DBDs and trauma exposure who received routine regular follow-up in an outpatient clinic (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u200910); and (iii) Typically developing youths (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u200918). All participants conducted an expression processing functional magnetic resonance imaging task twice, 8 weeks apart: (pretreatment and post-treatment for youths with DBDs).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Youths with DBDs and trauma exposure who received fluoxetine treatment compared to the other two groups showed: (i) significant improvement in externalizing, oppositional defiant disorder, irritability, anxiety-depression, and trauma-related symptoms; (ii) as a function of fearful expression intensity, significantly decreased amygdala response and increased recruitment of regions implicated in top-down attention control (insula cortex, inferior parietal lobule, and postcentral gyrus) and emotional regulation (ventromedial prefrontal cortex [vmPFC]); and (iii) correlation between DBD\/irritability symptom improvement and increased activation of top-down attention control areas (inferior parietal lobule, insula cortex, and postcentral gyrus) and an emotion regulation area (vmPFC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>This study provides preliminary evidence that a serotonergic agent (fluoxetine) can reduce disruptive behavior and mood symptoms in youths with DBDs and trauma exposure and that this may be mediated by enhanced activation of top-down attention control and emotion regulation areas (inferior parietal lobule, insula cortex, and vmPFC).<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/cap.2020.0174","type":"journal-article","created":{"date-parts":[[2021,6,2]],"date-time":"2021-06-02T11:58:11Z","timestamp":1622635091000},"page":"562-571","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Neural Responses to Fluoxetine in Youths with Disruptive Behavior and Trauma Exposure: A Pilot Study"],"prefix":"10.1177","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5117-2468","authenticated-orcid":false,"given":"Soonjo","family":"Hwang","sequence":"first","affiliation":[{"name":"Department of Psychiatry, University of Nebraska Medical Center, Omaha, Nebraska, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Unsun","family":"Chung","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Department of Radiology, Kyoungbook National University Hospital, Daegu, Republic of Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongmin","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Department of Radiology, Kyoungbook National University Hospital, Daegu, Republic of Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eunji","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Department of Radiology, Kyoungbook National University Hospital, Daegu, Republic of Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji-Woo","family":"Suk","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of Nebraska Medical Center, Omaha, Nebraska, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harma","family":"Meffert","sequence":"additional","affiliation":[{"name":"Target Holding, Groningen, The Netherlands."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher","family":"Kratochvil","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of Nebraska Medical Center, Omaha, Nebraska, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ellen","family":"Leibenluft","sequence":"additional","affiliation":[{"name":"Emotion and Development Branch, National Institute of Mental Health, Bethesda, Maryland, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6377-2361","authenticated-orcid":false,"given":"James","family":"Blair","sequence":"additional","affiliation":[{"name":"Center for Neurobehavioral Research, Boys Town National Research Hospital, Boys Town, Nebraska, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2021,10,14]]},"reference":[{"key":"e_1_3_3_2_1","unstructured":"Achenbach TM: Manual for the Child Behavior Checklist\/4\u201318 and 1991 Profile. 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