{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T19:14:10Z","timestamp":1790018050944,"version":"4.0.1"},"reference-count":53,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Child and Adolescent Psychopharmacology"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>Investigation into parental decision-making processes involving ketamine is of high priority, given the necessary role of parents in consenting to treatment. In this study, we examined parental attitudes toward the emerging use of ketamine in adolescent mood disorders and suicidality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Two hundred eighty-three English-speaking parents completed an online survey using Amazon Mechanical Turk on psychiatric use of ketamine, acceptability of treatment, and their perceptions of ketamine treatment. Data quality control measures were used to mitigate invalid reporting.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Parents reported high acceptability toward use of ketamine for suicidality, major depressive disorder, and bipolar disorder in adolescents. Primary concerns around ketamine involved its potential side effects and lack of United States Food and Drug Administration (FDA) approval. Responses indicated a preference for short-term applications and less invasive routes of administration for ketamine. Parent history of mental illness, familiarity with psychological treatments, and comfort using other mental health interventions in their children predicted greater acceptability of ketamine.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Although ketamine is not currently approved by the FDA for psychiatric use in children nor recommended outside of research protocols, these findings suggest that parents have interest in the application of ketamine as a treatment for pediatric mood disorders and point to future directions for research and clinical orientation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/cap.2021.0078","type":"journal-article","created":{"date-parts":[[2021,10,19]],"date-time":"2021-10-19T15:59:49Z","timestamp":1634659189000},"page":"553-561","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":14,"title":["Parental Attitudes Toward Use of Ketamine in Adolescent Mood Disorders and Suicidality"],"prefix":"10.1177","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9972-601X","authenticated-orcid":false,"given":"David S.","family":"Mathai","sequence":"first","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexis G.","family":"McCathern","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Western Psychiatric Hospital, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew G.","family":"Guzick","sequence":"additional","affiliation":[{"name":"Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, Texas, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1469-7764","authenticated-orcid":false,"given":"Sophie C.","family":"Schneider","sequence":"additional","affiliation":[{"name":"Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, Texas, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saira A.","family":"Weinzimmer","sequence":"additional","affiliation":[{"name":"Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, Texas, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra L.","family":"Cepeda","sequence":"additional","affiliation":[{"name":"Department of Psychology, University of Miami, Miami, Florida, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert","family":"Garcia-Romeu","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7631-3703","authenticated-orcid":false,"given":"Eric A.","family":"Storch","sequence":"additional","affiliation":[{"name":"Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, Texas, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,10,14]]},"reference":[{"key":"e_1_3_4_2_1","unstructured":"American Academy of Child and Adolescent Psychiatry: AACAP Psychopharmacology Committee Statement on Ketamine. Available at https:\/\/www.aacap.org\/AACAP\/Latest_News\/statement_ketmamine.aspx 2018."},{"key":"e_1_3_4_3_1","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326-5377.2007.tb01329.x"},{"key":"e_1_3_4_4_1","doi-asserted-by":"publisher","unstructured":"Bonaventura J Lam S Carlton M Boehm MA Gomez JL Sol\u00eds O S\u00e1nchez-Soto M Morris PJ Fredriksson I Thomas CJ Sibley DR Shaham Y Zarate CA Michaelides M: Pharmacological and behavioral divergence of ketamine enantiomers: Implications for abuse liability. Mol Psychiatry 2021. [Epub ahead of print]; DOI: 10.1038\/s41380-021-01093-2","DOI":"10.1038\/s41380-021-01093-2"},{"key":"e_1_3_4_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2032994"},{"key":"e_1_3_4_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2017.03.002"},{"key":"e_1_3_4_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.janxdis.2018.03.011"},{"key":"e_1_3_4_8_1","first-page":"464","article-title":"An MTurk crisis?","volume":"11","author":"Chmielewski M","year":"2020","unstructured":"Chmielewski M, , Kucker SC: An MTurk crisis?. Shifts in data quality and the impact on study results. Soc Psychol Personal Sci, 11:464\u2013473, 2020.","journal-title":"Shifts in data quality and the impact on study results. Soc Psychol Personal Sci"},{"key":"e_1_3_4_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)30385-3"},{"key":"e_1_3_4_10_1","doi-asserted-by":"crossref","unstructured":"Collishaw S Sellers R: Trends in child and adolescent mental health prevalence outcomes and inequalities. In: Mental Health and Illness of Children and Adolescents. Edited by Taylor E Verhulst F Wong J Yoshida K. Springer 2020.","DOI":"10.1007\/978-981-10-2348-4_9"},{"key":"e_1_3_4_11_1","article-title":"Death rates due to suicide and homicide among persons aged 10\u201324: United States, 2000-2017","author":"Curtin SC","year":"2019","unstructured":"Curtin SC, , Heron M: Death rates due to suicide and homicide among persons aged 10\u201324: United States, 2000-2017. NCHS Data Brief. Hyattsville, MD: National Center for Health Statistics, 2019.","journal-title":"NCHS Data Brief. Hyattsville,"},{"key":"e_1_3_4_12_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2019.19070684"},{"key":"e_1_3_4_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40272-014-0088-y"},{"key":"e_1_3_4_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2021.02.058"},{"key":"e_1_3_4_15_1","doi-asserted-by":"publisher","DOI":"10.1080\/02791072.2019.1587556"},{"key":"e_1_3_4_16_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.188.3.216"},{"key":"e_1_3_4_17_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2020.20010018"},{"key":"e_1_3_4_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpp.13202"},{"key":"e_1_3_4_19_1","doi-asserted-by":"publisher","DOI":"10.1159\/000510703"},{"key":"e_1_3_4_20_1","article-title":"Safe use of SSRIs in young adults: How strong is evidence for new suicide warning?","volume":"6","author":"Grunebaum MF","year":"2007","unstructured":"Grunebaum MF, , Mann JJ: Safe use of SSRIs in young adults: How strong is evidence for new suicide warning?. Curr psychiatry, 6:nihpa81089\u2013nihpa81089, 2007.","journal-title":"Curr psychiatry"},{"key":"e_1_3_4_21_1","doi-asserted-by":"publisher","DOI":"10.1037\/a0023536"},{"key":"e_1_3_4_22_1","article-title":"Who are these people?","volume":"2","author":"Huff C","year":"2015","unstructured":"Huff C, , Tingley D: \u201cWho are these people?\u201d Evaluating the demographic characteristics and political preferences of MTurk survey respondents. Res Polit, 2:2053168015604648, 2015.","journal-title":"Evaluating the demographic characteristics and political preferences of MTurk survey respondents. Res Polit"},{"key":"e_1_3_4_23_1","unstructured":"Janssen Research & Development LLC: Study to evaluate the efficacy and safety of 3 fixed doses of intranasal esketamine in addition to comprehensive standard of care for the rapid reduction of the symptoms of major depressive disorder including suicidal ideation in pediatric participants assessed to be at imminent risk for suicide. Identifier NCT03185819. https:\/\/clinicaltrials.gov\/ct2\/show\/NCT03185819 2021."},{"key":"e_1_3_4_24_1","doi-asserted-by":"publisher","DOI":"10.1177\/0269881108093587"},{"key":"e_1_3_4_25_1","unstructured":"Kepple A Madaan V: Ethics and pediatric psychopharmacology. American Academy of Child and Adolescent Psychiatry. Available at https:\/\/www.aacap.org\/app_themes\/aacap\/docs\/member_resources\/ethics\/in_workplace\/kepple_madaan_ethics_and_pediatric_psychopharmacology.pdf 2012."},{"key":"e_1_3_4_26_1","doi-asserted-by":"publisher","unstructured":"Kim S Rush BS Rice TR: A systematic review of therapeutic ketamine use in children and adolescents with treatment-resistant mood disorders. Eur Child Adolesc Psychiatry 2020. [Epub ahead of print]; DOI: 10.1007\/s00787-020-01542-3.","DOI":"10.1007\/s00787-020-01542-3"},{"key":"e_1_3_4_27_1","doi-asserted-by":"publisher","DOI":"10.1080\/02791072.1997.10400185"},{"key":"e_1_3_4_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s43440-020-00097-z"},{"key":"e_1_3_4_29_1","first-page":"199","article-title":"Subanesthetic effects of the noncompetitive NMDA antagonist, ketamine, in humans","volume":"51","author":"Krystal JH","year":"1994","unstructured":"Krystal JH, , Karper LP, , Seibyl JP, , Freeman GK, , Delaney R, , Bremner JD, , Heninger GR, , Bowers MB, , Charney DS: Subanesthetic effects of the noncompetitive NMDA antagonist, ketamine, in humans. Psychotomimetic, perceptual, cognitive, and neuroendocrine responses. Arch Gen Psychiatry, 51:199\u2013214, 1994.","journal-title":"Psychotomimetic, perceptual, cognitive, and neuroendocrine responses. Arch Gen Psychiatry"},{"key":"e_1_3_4_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/braincomms\/fcz025"},{"key":"e_1_3_4_31_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2016.00612"},{"key":"e_1_3_4_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaac.2011.05.011"},{"key":"e_1_3_4_33_1","article-title":"Distinction without a difference?","volume":"7","author":"Loepp E","year":"2020","unstructured":"Loepp E, , Kelly JT: Distinction without a difference?. An assessment of MTurk Worker types. Res Polit, 7:2053168019901185, 2020.","journal-title":"An assessment of MTurk Worker types. Res Polit"},{"key":"e_1_3_4_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2019.12.023"},{"key":"e_1_3_4_35_1","unstructured":"McElrath K Martin M: Bachelor's Degree Attainment in the United States: 2005 to 2019. The United States Census Bureau Washington DC USA 2021."},{"key":"e_1_3_4_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2020.06.050"},{"key":"e_1_3_4_37_1","doi-asserted-by":"publisher","unstructured":"McIntyre RS Rosenblat JD Nemeroff CB Sanacora G Murrough JW Berk M Brietzke E Dodd S Gorwood P Ho R Iosifescu DV Lopez Jaramillo C Kasper S Kratiuk K Lee JG Lee Y Lui LMW Mansur RB Papakostas GI Subramaniapillai M Thase M Vieta E Young AH Zarate CA Stahl S : Synthesizing the evidence for ketamine and esketamine in treatment-resistant depression: An International Expert Opinion on the Available Evidence and Implementation. Am J Psychiatry 2021. [Epub ahead of print]; DOI: 10.1176\/appi.ajp.2020.20081251","DOI":"10.1176\/appi.ajp.2020.20081251"},{"key":"e_1_3_4_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/add.15032"},{"key":"e_1_3_4_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-021-01336-3"},{"key":"e_1_3_4_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1300342"},{"key":"e_1_3_4_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10459-010-9222-y"},{"key":"e_1_3_4_42_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2020.21020172"},{"key":"e_1_3_4_43_1","doi-asserted-by":"publisher","DOI":"10.3758\/s13428-013-0434-y"},{"key":"e_1_3_4_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2016.193"},{"key":"e_1_3_4_45_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e31825ae442"},{"key":"e_1_3_4_46_1","first-page":"25","article-title":"The ethics and science of medicating children","volume":"6","author":"Sparks JA","year":"2004","unstructured":"Sparks JA, , Duncan BL: The ethics and science of medicating children. Ethical Hum Psychol Psychiatry, 6:25\u201339, 2004.","journal-title":"Ethical Hum Psychol Psychiatry"},{"key":"e_1_3_4_47_1","doi-asserted-by":"publisher","DOI":"10.1089\/cap.2019.0134"},{"key":"e_1_3_4_48_1","doi-asserted-by":"publisher","DOI":"10.1089\/cap.2020.0008"},{"key":"e_1_3_4_49_1","doi-asserted-by":"publisher","DOI":"10.1037\/pha0000235"},{"key":"e_1_3_4_50_1","doi-asserted-by":"crossref","unstructured":"Sumner RL Chacko E McMillan R Spriggs MJ Anderson C Chen J French A Jung S Rajan A Malpas G Hay J Ponton R Muthukumaraswamy SD Sundram F: A qualitative and quantitative account of patient's experiences of ketamine and its antidepressant properties. J Psychopharmacol 269881121998321 2021.","DOI":"10.1177\/0269881121998321"},{"key":"e_1_3_4_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addbeh.2005.05.028"},{"issue":"2","key":"e_1_3_4_52_1","first-page":"S19","article-title":"The factors of ketamine that affect sedation in children with oncology procedures: Parent satisfaction perspective","volume":"97","author":"Traivaree C","year":"2014","unstructured":"Traivaree C, , Jindakam W, , Monsereenusorn C, , Rujkijyanont P, , Lumkul R: The factors of ketamine that affect sedation in children with oncology procedures: Parent satisfaction perspective. J Med Assoc Thai, 97 Suppl 2:S19\u2013S24, 2014.","journal-title":"J Med Assoc Thai"},{"key":"e_1_3_4_53_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2017.17040472"},{"key":"e_1_3_4_54_1","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.1058"}],"container-title":["Journal of Child and Adolescent Psychopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/cap.2021.0078","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/cap.2021.0078","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/cap.2021.0078","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T14:56:13Z","timestamp":1777388173000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/cap.2021.0078"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10]]},"references-count":53,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2021,10]]}},"alternative-id":["10.1089\/cap.2021.0078"],"URL":"https:\/\/doi.org\/10.1089\/cap.2021.0078","relation":{},"ISSN":["1044-5463","1557-8992"],"issn-type":[{"value":"1044-5463","type":"print"},{"value":"1557-8992","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10]]}}}