{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T20:21:25Z","timestamp":1777494085510,"version":"3.51.4"},"reference-count":48,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Child and Adolescent Psychopharmacology"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Antipsychotics carry a higher-risk profile than other psychotropic medications and may be prescribed for youth with conditions in which other first-line treatments are more appropriate. This study aimed to evaluate the population-level effect of the Safer Use of Antipsychotics in Youth (SUAY) trial, which aimed to reduce person-days of antipsychotic use among participants.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We conducted an interrupted time series analysis using segmented regression to measure changes in prescribing trends of antipsychotic initiation rates pre-SUAY and post-SUAY trial at four U.S. health systems between 2013 and 2020.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      In our overall model, adjusted for age and insurance type, antipsychotic initiation rates decreased by 0.73 (95% confidence interval [CI]: 0.30, 1.16,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = 0.002) prescriptions per 10,000 person-months before the SUAY trial. In the first quarter following the start of the trial, there was an immediate decrease in the rate of antipsychotic initiations of 6.57 (95% CI: 0.99, 12.15) prescriptions per 10,000 person-months. When comparing the posttrial period to the pretrial period, there was an increase of 1.09 (95% CI: 0.32, 1.85) prescriptions per 10,000 person-months, but the increasing rate in the posttrial period alone was not statistically significant (0.36 prescriptions per 10,000 person-months, 95% CI: \u22120.27, 0.99).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The declining trend of antipsychotic initiation seen between 2013 and 2018 (pre-SUAY trial) may have naturally reached a level at which prescribing was clinically warranted and appropriate, resulting in a floor effect. The COVID-19 pandemic, which began in the final three quarters of the posttrial period, may also be related to increased antipsychotic medication initiation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/cap.2024.0007","type":"journal-article","created":{"date-parts":[[2024,5,14]],"date-time":"2024-05-14T13:18:40Z","timestamp":1715692720000},"page":"310-318","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Evaluation of the Safer Use of Antipsychotics in Youth Study on Population Level Antipsychotic Initiation: An Interrupted Time Series Analysis"],"prefix":"10.1177","volume":"34","author":[{"given":"Laura M.","family":"West","sequence":"first","affiliation":[{"name":"Department of Epidemiology, University of Washington Seattle, Seattle, Washington, USA."},{"name":"Kaiser Permanente Washington Health Research Institute, Seattle, Washington, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen J.","family":"Mooney","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, University of Washington Seattle, Seattle, Washington, USA."},{"name":"Harborview Injury Prevention &amp; Research Center, University of Washington, Seattle, Washington, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1565-2346","authenticated-orcid":false,"given":"Laura","family":"Chavez","sequence":"additional","affiliation":[{"name":"Center for Child Health Equity and Outcomes Research, The Abigail Wexner Research Institute at Nationwide Children\u2019s Hospital, Columbus, Ohio, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arne","family":"Beck","sequence":"additional","affiliation":[{"name":"Kaiser Permanente Colorado, Institute for Health Research, Denver, Colorado, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregory N.","family":"Clarke","sequence":"additional","affiliation":[{"name":"Kaiser Permanente Northwest Center for Health Research, Portland, Oregon, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chester J.","family":"Pabiniak","sequence":"additional","affiliation":[{"name":"Kaiser Permanente Washington Health Research Institute, Seattle, Washington, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne D.","family":"Renz","sequence":"additional","affiliation":[{"name":"Kaiser Permanente Washington Health Research Institute, Seattle, Washington, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4795-7902","authenticated-orcid":false,"given":"Robert B.","family":"Penfold","sequence":"additional","affiliation":[{"name":"Kaiser Permanente Washington Health Research Institute, Seattle, Washington, USA."},{"name":"Department of Health Systems and Population Health, University of Washington, Seattle, Washington, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2024,9,16]]},"reference":[{"key":"e_1_3_5_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/1475-6773.13297"},{"key":"e_1_3_5_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/1475-6773.12539"},{"key":"e_1_3_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jadohealth.2020.09.002"},{"key":"e_1_3_5_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyw098"},{"key":"e_1_3_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.encep.2020.05.011"},{"key":"e_1_3_5_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-019-1346-1"},{"key":"e_1_3_5_8_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ps.201700536"},{"key":"e_1_3_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaac.2020.09.023"},{"key":"e_1_3_5_10_1","doi-asserted-by":"publisher","DOI":"10.1089\/cap.2020.0190"},{"key":"e_1_3_5_11_1","doi-asserted-by":"publisher","DOI":"10.1089\/cap.2004.14.372"},{"key":"e_1_3_5_12_1","unstructured":"Christian R Saavedra L Gaynes BN et al. 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