{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T19:12:27Z","timestamp":1790795547978,"version":"4.1.0"},"reference-count":54,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Child and Adolescent Psychopharmacology"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>While available for decades, the use of bupropion has increased in recent years. To provide an updated review on the use of bupropion, this article aimed to describe bupropion prescription details, potential indication, and treatment duration in children, young adults, and adults starting bupropion treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Individuals aged 6\u201364 newly initiating bupropion hydrochloride treatment were identified from commercial claims data (MarketScan, 1\/1\/2016\u201312\/31\/2022). New bupropion use was defined as at least 1 year without any prior bupropion dispensed prescription. Potential indications for bupropion treatment were identified from inpatient\/outpatient records (ICD-10-CM diagnoses) in the 30 days prior to bupropion initiation. All analyses were stratified by age: children (6\u201317 years), young adults (18\u201329 years), and adults (30\u201364 years) and treatment duration up to 1 year was estimated with Kaplan\u2013Meier estimation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>The study sample included 39,833 children, 177,710 young adults, and 548,557 adults newly initiating bupropion treatment. Bupropion extended-release 24-hour 150 mg was the most common (62%) formulation and dose at initiation. Depression was the most prevalent potential indication (children = 57%, young adults = 47%, adults = 36%) and attention-deficit\/hyperactivity disorder (ADHD) was the next most common potential indication in children (25%) and young adults (12%); tobacco cessation and weight loss also identified as potential indications. Twenty-two percent of bupropion initiators were on concurrent selective serotonin reuptake inhibitor treatment. In children, suicidal ideation (16.3%), poisoning (5.9%), and anorexia or bulimia nervosa (2.2%) were relatively common diagnoses prior to bupropion initiation. Overall, 39%\u201345% remained on bupropion treatment for at least 6 months, with variation by potential indication.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The antidepressant bupropion is prescribed to children, young adults, and adults for a variety of indications in the United States, with depression and ADHD the most common indications in children. As the prescribing of bupropion becomes more widespread, additional safety and effectiveness data will be necessary to inform prescribing decisions, particularly in populations with unknown efficacy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/cap.2024.0111","type":"journal-article","created":{"date-parts":[[2024,12,20]],"date-time":"2024-12-20T11:54:04Z","timestamp":1734695644000},"page":"135-144","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Current Utilization of Bupropion Treatment in Children, Young Adults, and Adults in the United States"],"prefix":"10.1177","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4056-8405","authenticated-orcid":false,"given":"Greta A.","family":"Bushnell","sequence":"first","affiliation":[{"name":"Center for Pharmacoepidemiology and Treatment Science, Health Care Policy and Aging Research, Rutgers Institute for Health, New Brunswick, New Jersey, USA."},{"name":"Department of Biostatistics and Epidemiology, Rutgers University School of Public Health, Piscataway, New Jersey, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel B.","family":"Horton","sequence":"additional","affiliation":[{"name":"Center for Pharmacoepidemiology and Treatment Science, Health Care Policy and Aging Research, Rutgers Institute for Health, New Brunswick, New Jersey, USA."},{"name":"Department of Biostatistics and Epidemiology, Rutgers University School of Public Health, Piscataway, New Jersey, USA."},{"name":"Department of Pediatrics, Rutgers Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Olfson","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Columbia University Irving Medical Center, New York, New York, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hillary","family":"Samples","sequence":"additional","affiliation":[{"name":"Center for Pharmacoepidemiology and Treatment Science, Health Care Policy and Aging Research, Rutgers Institute for Health, New Brunswick, New Jersey, USA."},{"name":"Department of Health Behavior, Society and Policy, Rutgers University School of Public Health, Piscataway, New Jersey, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth A.","family":"Suarez","sequence":"additional","affiliation":[{"name":"Center for Pharmacoepidemiology and Treatment Science, Health Care Policy and Aging Research, Rutgers Institute for Health, New Brunswick, New Jersey, USA."},{"name":"Department of Biostatistics and Epidemiology, Rutgers University School of Public Health, Piscataway, New Jersey, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diane P.","family":"Calello","sequence":"additional","affiliation":[{"name":"New Jersey Poison Information and Education System, Department of Emergency Medicine, New Jersey Medical School Rutgers Biomedical and Health Sciences, Newark, New Jersey, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,4,9]]},"reference":[{"key":"e_1_3_4_2_1","volume-title":"Practice Guideline for the Treatment of Patients with Major Depressive Disorder","author":"American Psychiatric Association","year":"2010","unstructured":"American Psychiatric Association. 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