{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T20:58:35Z","timestamp":1781557115377,"version":"3.54.5"},"reference-count":174,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2025,3,26]],"date-time":"2025-03-26T00:00:00Z","timestamp":1742947200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Child and Adolescent Psychopharmacology"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>Despite growing knowledge of the underlying neurobiology of autism spectrum disorder (ASD) and related neurogenetic syndromes, treatment discovery has remained elusive. In this review, we provide a blueprint for translational precision medicine in ASD and related neurogenetic syndromes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>The discovery of trofinetide for Rett syndrome (RTT) is described, and the role of nonmammalian, mammalian, and stem cell model systems in the identification of molecular targets and drug screening is discussed. We then provide a framework for translating preclinical findings to human clinical trials, including the role of biomarkers in selecting molecular targets and evaluating target engagement, and discuss how to leverage these findings for future ASD drug development.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Multiple preclinical model systems for ASD have been developed, each with tradeoffs with regard to suitability for high-throughput small molecule screening, conservation across species, and behavioral face validity. Future clinical trials should incorporate biomarkers and intermediate phenotypes to demonstrate target engagement. Factors that contributed to the approval of trofinetide for RTT included replicated findings in mouse models, a well-studied natural history of the syndrome, development of RTT-specific outcome measures, and strong engagement of the RTT family community.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>The translation of our growing understanding of the neurobiology of ASD to human drug discovery will require a precision medicine approach, including the use of multiple model systems for molecular target selection, evaluation of target engagement, and clinical trial design strategies that address heterogeneity, power, and the placebo response.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/cap.2025.0023","type":"journal-article","created":{"date-parts":[[2025,3,26]],"date-time":"2025-03-26T12:26:06Z","timestamp":1742991966000},"page":"178-193","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["A Blueprint for Translational Precision Medicine in Autism Spectrum Disorder and Related Neurogenetic Syndromes"],"prefix":"10.1177","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8026-6970","authenticated-orcid":false,"given":"Robyn P.","family":"Thom","sequence":"first","affiliation":[{"name":"Massachusetts General Hospital Lurie Center for Autism, Harvard Medical School, Lexington, Massachusetts, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tracy L.","family":"Warren","sequence":"additional","affiliation":[{"name":"Yale School of Medicine, New Haven, Connecticut, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suha","family":"Khan","sequence":"additional","affiliation":[{"name":"Child Study Center, Yale School of Medicine, New Haven, Connecticut, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca A.","family":"Muhle","sequence":"additional","affiliation":[{"name":"Columbia University and New York State Psychiatric Institute, New York, New York, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul P.","family":"Wang","sequence":"additional","affiliation":[{"name":"Yale School of Medicine, New Haven, Connecticut, USA."},{"name":"Simons Foundation Autism Research Initiative, New Haven, Connecticut, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristen","family":"Brennand","sequence":"additional","affiliation":[{"name":"Yale School of Medicine, New Haven, Connecticut, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole R.","family":"Z\u00fcrcher","sequence":"additional","affiliation":[{"name":"Massachusetts General Hospital Lurie Center for Autism, Harvard Medical School, Lexington, Massachusetts, USA."},{"name":"Athinoula A. Martinos Center for Biomedical Imaging, Boston, Massachusetts, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy","family":"Veenstra-VanderWeele","sequence":"additional","affiliation":[{"name":"Columbia University and New York State Psychiatric Institute, New York, New York, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen J.","family":"Hoffman","sequence":"additional","affiliation":[{"name":"Child Study Center, Yale School of Medicine, New Haven, Connecticut, USA."},{"name":"Department of Neuroscience, Yale School of Medicine, New Haven, Connecticut, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,3,26]]},"reference":[{"key":"e_1_3_3_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/HMG\/DDAB104"},{"key":"e_1_3_3_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/13810"},{"key":"e_1_3_3_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/1362361314542955"},{"key":"e_1_3_3_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/WCO.0000000000000542"},{"key":"e_1_3_3_6_1","doi-asserted-by":"publisher","DOI":"10.1126\/SCITRANSLMED.AAB4109"},{"key":"e_1_3_3_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/S11689-016-9181-6"},{"key":"e_1_3_3_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/NRD.2017.221"},{"key":"e_1_3_3_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.CELL.2014.06.017"},{"key":"e_1_3_3_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/FPSYT.2022.1079006"},{"key":"e_1_3_3_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/DBP.0000000000000351"},{"key":"e_1_3_3_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2008.12.003"},{"key":"e_1_3_3_13_1","doi-asserted-by":"publisher","DOI":"10.1101\/2024.02.28.582546"},{"key":"e_1_3_3_14_1","doi-asserted-by":"publisher","DOI":"10.1021\/ACS.JMEDCHEM.3C02165"},{"key":"e_1_3_3_15_1","doi-asserted-by":"publisher","DOI":"10.1242\/JEB.003939"},{"key":"e_1_3_3_16_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0615-07.2007"},{"key":"e_1_3_3_17_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1311685111"},{"key":"e_1_3_3_18_1","unstructured":"Cavazzoni P Marks P. FDA opens doors for more treatments for rare diseases through the new START pilot program | FDA. 2024. Available from: https:\/\/www.fda.gov\/drugs\/our-perspective\/fda-opens-doors-more-treatments-rare-diseases-through-new-start-pilot-program [Last accessed: February19 2025]."},{"key":"e_1_3_3_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.STEM.2020.06.004"},{"key":"e_1_3_3_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/NATURE09806"},{"key":"e_1_3_3_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/85906"},{"key":"e_1_3_3_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/S41586-024-07310-6"},{"key":"e_1_3_3_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.CELL.2017.04.035"},{"key":"e_1_3_3_24_1","doi-asserted-by":"publisher","DOI":"10.1001\/JAMA.2013.2270"},{"key":"e_1_3_3_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/BRAIN\/AWAA045"},{"key":"e_1_3_3_26_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmedgenet-2013-102113"},{"key":"e_1_3_3_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/HMG\/9.6.869"},{"key":"e_1_3_3_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stemcr.2018.10.003"},{"key":"e_1_3_3_29_1","doi-asserted-by":"publisher","DOI":"10.1053\/J.SEMNUCLMED.2017.05.006"},{"key":"e_1_3_3_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/DVG.23405"},{"key":"e_1_3_3_31_1","doi-asserted-by":"publisher","DOI":"10.1177\/1362361318804192"},{"key":"e_1_3_3_32_1","doi-asserted-by":"publisher","DOI":"10.1101\/2024.08.23.609190"},{"key":"e_1_3_3_33_1","doi-asserted-by":"publisher","DOI":"10.1101\/2023.10.28.564543"},{"key":"e_1_3_3_34_1","unstructured":"Fields R. Zolgensma creation story reveals truths about drug pricing\u2014ProPublica. 2025. Available from: https:\/\/www.propublica.org\/article\/zolgensma-sma-novartis-drug-prices-gene-therapy-avexis [Last accessed: February19 2025]."},{"key":"e_1_3_3_35_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMOA1702752"},{"key":"e_1_3_3_36_1","unstructured":"Food and Drug Administration. CDER Pilot Grant Program: Standard Core Clinical Outcome Assessments (COAs) and Their Related Endpoints | FDA. 2024. Available from: https:\/\/www.fda.gov\/drugs\/development-approval-process-drugs\/cder-pilot-grant-program-standard-core-clinical-outcome-assessments-coas-and-their-related-endpoints [Last accessed: February19 2025]."},{"key":"e_1_3_3_37_1","unstructured":"Food and Drug Administration. Demonstrating Substantial Evidence of Effectiveness for Human Drug and Biological Products Guidance for Industry DRAFT GUIDANCE. 2023a. Available from: https:\/\/www.fda.gov\/vaccines-blood-biologics\/guidance-compliance-regulatory-information-biologics [Last accessed: February19 2025]."},{"key":"e_1_3_3_38_1","unstructured":"Food and Drug Administration. Demonstrating Substantial Evidence of Effectiveness With One Adequate and Well-Controlled Clinical Investigation and Confirmatory Evidence Guidance for Industry DRAFT GUIDANCE. 2023b. Available from: https:\/\/www.fda.gov\/vaccines-blood-biologics\/guidance-compliance-regulatory-information-biologics\/biologics-guidances [Last accessed: February19 2025]."},{"key":"e_1_3_3_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/S41588-022-01104-0"},{"key":"e_1_3_3_40_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000007316"},{"key":"e_1_3_3_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.PEDIATRNEUROL.2017.07.002"},{"key":"e_1_3_3_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/NN.4592"},{"key":"e_1_3_3_43_1","doi-asserted-by":"publisher","DOI":"10.1126\/SCIENCE.ABN3943"},{"key":"e_1_3_3_44_1","doi-asserted-by":"publisher","DOI":"10.1097\/JCP.0000000000000536"},{"key":"e_1_3_3_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/S41588-019-0344-8"},{"key":"e_1_3_3_46_1","doi-asserted-by":"publisher","DOI":"10.1517\/17460440902988464"},{"key":"e_1_3_3_47_1","volume-title":"ECDEU Assessment Manual for Psychopharmacology","author":"Guy W","year":"1976","unstructured":"Guy W. ECDEU Assessment Manual for Psychopharmacology. National Institute of Mental Health: Washington, DC; 1976."},{"key":"e_1_3_3_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.NEUBIOREV.2020.04.012"},{"key":"e_1_3_3_49_1","doi-asserted-by":"publisher","DOI":"10.1038\/S41398-019-0457-Y"},{"key":"e_1_3_3_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.STEMCR.2017.09.006"},{"key":"e_1_3_3_51_1","doi-asserted-by":"publisher","DOI":"10.1038\/NATURE21369"},{"key":"e_1_3_3_52_1","doi-asserted-by":"publisher","DOI":"10.3390\/BIOTECH13010001"},{"key":"e_1_3_3_53_1","doi-asserted-by":"publisher","DOI":"10.1038\/S41398-023-02317-5"},{"key":"e_1_3_3_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.STEMCR.2017.06.012"},{"key":"e_1_3_3_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.NEURON.2015.12.039"},{"key":"e_1_3_3_56_1","doi-asserted-by":"publisher","DOI":"10.1146\/ANNUREV-BIOENG-062117-121056"},{"key":"e_1_3_3_57_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-0716-1759-5_9"},{"key":"e_1_3_3_58_1","doi-asserted-by":"publisher","DOI":"10.1007\/S40265-019-01162-5"},{"key":"e_1_3_3_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.EBIOM.2016.05.011"},{"key":"e_1_3_3_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.JAAC.2016.06.008"},{"key":"e_1_3_3_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/BS.ACDB.2022.10.005"},{"key":"e_1_3_3_62_1","doi-asserted-by":"publisher","DOI":"10.1038\/S41467-018-04882-6"},{"key":"e_1_3_3_63_1","doi-asserted-by":"publisher","DOI":"10.1525\/2\/EMBR.202050958"},{"key":"e_1_3_3_64_1","doi-asserted-by":"publisher","DOI":"10.1001\/JAMA.2023.13295"},{"key":"e_1_3_3_65_1","doi-asserted-by":"publisher","DOI":"10.3389\/FPSYT.2021.709382"},{"key":"e_1_3_3_66_1","doi-asserted-by":"publisher","DOI":"10.1038\/NATURE19357"},{"key":"e_1_3_3_67_1","doi-asserted-by":"publisher","DOI":"10.1176\/APPI.AJP.22010014"},{"key":"e_1_3_3_68_1","doi-asserted-by":"publisher","DOI":"10.1007\/S11910-024-01394-3"},{"key":"e_1_3_3_69_1","doi-asserted-by":"publisher","DOI":"10.1080\/14737175.2023.2245568"},{"key":"e_1_3_3_70_1","doi-asserted-by":"publisher","DOI":"10.3389\/FPHAR.2023.1341746"},{"key":"e_1_3_3_71_1","doi-asserted-by":"publisher","DOI":"10.1001\/JAMAPEDIATRICS.2013.2698"},{"key":"e_1_3_3_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.CELL.2021.10.003"},{"key":"e_1_3_3_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.NEURON.2024.09.020"},{"key":"e_1_3_3_74_1","doi-asserted-by":"publisher","DOI":"10.1038\/S41467-021-21713-3"},{"key":"e_1_3_3_75_1","doi-asserted-by":"publisher","DOI":"10.3389\/FNMOL.2016.00055"},{"key":"e_1_3_3_76_1","doi-asserted-by":"publisher","DOI":"10.1038\/NRD.2018.222"},{"key":"e_1_3_3_77_1","doi-asserted-by":"publisher","DOI":"10.1038\/S41591-020-0806-7"},{"key":"e_1_3_3_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.CELL.2012.02.060"},{"key":"e_1_3_3_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.TIPS.2006.04.004"},{"key":"e_1_3_3_80_1","doi-asserted-by":"publisher","DOI":"10.1038\/S41586-023-06473-Y"},{"key":"e_1_3_3_81_1","doi-asserted-by":"publisher","DOI":"10.1038\/S41421-023-00525-3"},{"key":"e_1_3_3_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0306-4522(01)00378-5"},{"key":"e_1_3_3_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.NEURON.2015.01.010"},{"key":"e_1_3_3_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.CELL.2018.01.012"},{"key":"e_1_3_3_85_1","doi-asserted-by":"publisher","DOI":"10.1007\/S12264-014-1434-8"},{"key":"e_1_3_3_86_1","doi-asserted-by":"publisher","DOI":"10.1007\/S10803-005-5035-X"},{"key":"e_1_3_3_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.CELL.2017.10.021"},{"key":"e_1_3_3_88_1","doi-asserted-by":"publisher","DOI":"10.7554\/ELIFE.52629"},{"key":"e_1_3_3_89_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2012.01.011"},{"key":"e_1_3_3_90_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0306-4522(98)00143-2"},{"key":"e_1_3_3_91_1","doi-asserted-by":"publisher","DOI":"10.1038\/S41380-024-02776-2"},{"key":"e_1_3_3_92_1","doi-asserted-by":"publisher","DOI":"10.1242\/DMM.019620"},{"key":"e_1_3_3_93_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.EURONEURO.2021.05.010"},{"key":"e_1_3_3_94_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.EURONEURO.2021.05.010"},{"key":"e_1_3_3_95_1","doi-asserted-by":"publisher","DOI":"10.1073\/PNAS.1912049116\/-\/DCSUPPLEMENTAL"},{"key":"e_1_3_3_96_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1206593"},{"key":"e_1_3_3_97_1","doi-asserted-by":"publisher","DOI":"10.3389\/FNINT.2020.00016"},{"key":"e_1_3_3_98_1","doi-asserted-by":"publisher","DOI":"10.1186\/S13024-018-0297-X"},{"key":"e_1_3_3_99_1","doi-asserted-by":"publisher","DOI":"10.1038\/NATURE13975"},{"key":"e_1_3_3_100_1","doi-asserted-by":"publisher","DOI":"10.1038\/S41586-023-06564-W"},{"key":"e_1_3_3_101_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.NEURON.2012.03.009"},{"key":"e_1_3_3_102_1","doi-asserted-by":"publisher","DOI":"10.1186\/S13229-017-0121-4"},{"key":"e_1_3_3_103_1","doi-asserted-by":"publisher","DOI":"10.1111\/1469-7610.00236"},{"key":"e_1_3_3_104_1","doi-asserted-by":"publisher","DOI":"10.3389\/FPHYS.2019.00154"},{"key":"e_1_3_3_105_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.22124"},{"key":"e_1_3_3_106_1","doi-asserted-by":"publisher","DOI":"10.1177\/0883073815579707"},{"key":"e_1_3_3_107_1","doi-asserted-by":"publisher","DOI":"10.1038\/S41591-023-02398-1"},{"key":"e_1_3_3_108_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.PEDIATRNEUROL.2023.11.005"},{"key":"e_1_3_3_109_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.CELL.2014.01.027"},{"key":"e_1_3_3_110_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.EJPS.2017.05.032"},{"key":"e_1_3_3_111_1","doi-asserted-by":"publisher","DOI":"10.1002\/acn3.533"},{"key":"e_1_3_3_112_1","doi-asserted-by":"publisher","DOI":"10.1176\/APPI.AJP.21100992"},{"key":"e_1_3_3_113_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22179610"},{"key":"e_1_3_3_114_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.CCELL.2021.01.011"},{"key":"e_1_3_3_115_1","doi-asserted-by":"publisher","DOI":"10.1038\/S41586-021-04358-6"},{"key":"e_1_3_3_116_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.TIPS.2023.09.008"},{"key":"e_1_3_3_117_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000201897"},{"key":"e_1_3_3_118_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.MEDJ.2024.06.007"},{"key":"e_1_3_3_119_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.MEDJ.2024.05.018"},{"key":"e_1_3_3_120_1","doi-asserted-by":"publisher","DOI":"10.1093\/NAR\/GKAE974"},{"key":"e_1_3_3_121_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.XGEN.2022.100250"},{"key":"e_1_3_3_122_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.CELREP.2017.03.052"},{"key":"e_1_3_3_123_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0953-816X.2004.03320.x"},{"key":"e_1_3_3_124_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4332-06.2006"},{"key":"e_1_3_3_125_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1366-14.2014"},{"key":"e_1_3_3_126_1","doi-asserted-by":"publisher","DOI":"10.1038\/NRN2719"},{"key":"e_1_3_3_127_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.TINS.2009.01.007"},{"key":"e_1_3_3_128_1","doi-asserted-by":"publisher","DOI":"10.1038\/NPROT.2013.143"},{"key":"e_1_3_3_129_1","doi-asserted-by":"publisher","DOI":"10.1101\/GR.169101"},{"key":"e_1_3_3_130_1","doi-asserted-by":"publisher","DOI":"10.1126\/SCIENCE.1183090"},{"key":"e_1_3_3_131_1","doi-asserted-by":"publisher","DOI":"10.1034\/J.1601-183X.2003.00037.X"},{"key":"e_1_3_3_132_1","doi-asserted-by":"publisher","DOI":"10.1038\/S41593-021-00906-5"},{"key":"e_1_3_3_133_1","doi-asserted-by":"publisher","DOI":"10.1007\/S40273-021-01065-Y"},{"key":"e_1_3_3_134_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5193-09.2010"},{"key":"e_1_3_3_135_1","doi-asserted-by":"publisher","DOI":"10.1111\/JCPP.12837"},{"key":"e_1_3_3_136_1","doi-asserted-by":"publisher","DOI":"10.1002\/DVDY.24398"},{"key":"e_1_3_3_137_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(02)00768-7"},{"key":"e_1_3_3_138_1","doi-asserted-by":"publisher","DOI":"10.1038\/NPROT.2014.171"},{"key":"e_1_3_3_139_1","doi-asserted-by":"publisher","DOI":"10.1176\/APPI.AJP.21090896"},{"key":"e_1_3_3_140_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.JAAC.2010.08.018"},{"key":"e_1_3_3_141_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.NEURON.2015.12.008"},{"key":"e_1_3_3_142_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.OMTM.2017.04.006"},{"key":"e_1_3_3_143_1","doi-asserted-by":"publisher","DOI":"10.1038\/NPP.2017.236"},{"key":"e_1_3_3_144_1","doi-asserted-by":"publisher","DOI":"10.1038\/NRN3707"},{"key":"e_1_3_3_145_1","doi-asserted-by":"publisher","DOI":"10.1101\/2023.12.22.573108"},{"key":"e_1_3_3_146_1","doi-asserted-by":"publisher","DOI":"10.1038\/NMETH.1625"},{"key":"e_1_3_3_147_1","doi-asserted-by":"publisher","DOI":"10.1007\/S00259-016-3476-4"},{"key":"e_1_3_3_148_1","doi-asserted-by":"publisher","DOI":"10.1093\/HMG\/DDT500"},{"key":"e_1_3_3_149_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.NEUROPHARM.2018.12.024"},{"key":"e_1_3_3_150_1","doi-asserted-by":"publisher","DOI":"10.2165\/00023210-200115090-00001"},{"key":"e_1_3_3_151_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.STEMCR.2017.06.018"},{"key":"e_1_3_3_152_1","doi-asserted-by":"publisher","DOI":"10.1038\/S41386-023-01573-9"},{"key":"e_1_3_3_153_1","doi-asserted-by":"publisher","DOI":"10.1038\/S41591-024-03057-9"},{"key":"e_1_3_3_154_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mp.4002076"},{"key":"e_1_3_3_155_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0812394106"},{"key":"e_1_3_3_156_1","doi-asserted-by":"publisher","DOI":"10.1525\/2\/EMMM.202012523"},{"key":"e_1_3_3_157_1","doi-asserted-by":"publisher","DOI":"10.1001\/JAMANEUROL.2015.0443"},{"key":"e_1_3_3_158_1","doi-asserted-by":"publisher","DOI":"10.1038\/NPP.2016.237"},{"key":"e_1_3_3_159_1","doi-asserted-by":"publisher","DOI":"10.1176\/APPI.AJP.20230153"},{"key":"e_1_3_3_160_1","doi-asserted-by":"publisher","DOI":"10.1007\/S00213-013-3334-Z"},{"key":"e_1_3_3_161_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.NEURON.2024.01.029"},{"key":"e_1_3_3_162_1","doi-asserted-by":"publisher","DOI":"10.1176\/APPI.AJP.21050485"},{"key":"e_1_3_3_163_1","doi-asserted-by":"publisher","DOI":"10.1186\/1742-2094-6-19"},{"key":"e_1_3_3_164_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.CELREP.2023.112243"},{"key":"e_1_3_3_165_1","doi-asserted-by":"publisher","DOI":"10.1089\/HUM.2020.182"},{"key":"e_1_3_3_166_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.NEURON.2021.03.030"},{"key":"e_1_3_3_167_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.CELL.2013.10.020"},{"key":"e_1_3_3_168_1","doi-asserted-by":"publisher","DOI":"10.3390\/GENES15070821"},{"key":"e_1_3_3_169_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.MOLCEL.2020.05.016"},{"key":"e_1_3_3_170_1","doi-asserted-by":"publisher","DOI":"10.1038\/GT.2017.64"},{"key":"e_1_3_3_171_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.NEURON.2013.05.029"},{"key":"e_1_3_3_172_1","doi-asserted-by":"publisher","DOI":"10.1038\/S41588-022-01148-2"},{"key":"e_1_3_3_173_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2257-10.2010"},{"key":"e_1_3_3_174_1","doi-asserted-by":"publisher","DOI":"10.1136\/JMEDGENET-2012-101203"},{"key":"e_1_3_3_175_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.NEUBIOREV.2015.02.002"}],"container-title":["Journal of Child and Adolescent Psychopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/cap.2025.0023","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/cap.2025.0023","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/cap.2025.0023","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T20:48:44Z","timestamp":1781556524000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/cap.2025.0023"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,26]]},"references-count":174,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,5]]}},"alternative-id":["10.1089\/cap.2025.0023"],"URL":"https:\/\/doi.org\/10.1089\/cap.2025.0023","relation":{},"ISSN":["1044-5463","1557-8992"],"issn-type":[{"value":"1044-5463","type":"print"},{"value":"1557-8992","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,26]]}}}