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It was tested whether the combination of iodine-131(\n                    <jats:sup>131<\/jats:sup>\n                    I)-metuximab with chemoembolization could improve outcomes in patients with intermediate HCC. Between April 2008 and April 2009, 110 patients with unresectable HCC were treated with 113 intra-arterial\n                    <jats:sup>131<\/jats:sup>\n                    I-metuximab injections combined with chemoembolization (mean, 1.03 per patient; median, 1; range, 1\u20132), followed by 264 sessions of transcatheter arterial chemoembolization (mean, 2.4 per patient; median, 3; range, 1\u20136). The survival rates at 6, 12, and 18 months were 88.2%, 79.1%, and 57.4%, respectively, by the Kaplan-Meier method. Of these patients, 12% exhibited grade 3\/4 bilirubin toxicity, 5% exhibited grade 3\/4 white blood count toxicity, and 7% exhibited grade 3\/4 platelet toxicity. Response rates based on World Health Organization and European Association for the Study of the Liver criteria were 42.73% and 61.82%, respectively. The combination of\n                    <jats:sup>131<\/jats:sup>\n                    I-metuximab and chemoembolization appeared to extend survival in patients with unresectable HCC compared with historical controls, as well as being well tolerated by patients with Child-Pugh A and B. This combination may represent a promising treatment modality for patients with intermediate HCC.\n                  <\/jats:p>","DOI":"10.1089\/cbr.2010.0801","type":"journal-article","created":{"date-parts":[[2011,1,5]],"date-time":"2011-01-05T07:10:35Z","timestamp":1294211435000},"page":"657-663","source":"Crossref","is-referenced-by-count":15,"title":["Hepatic Arterial Iodine-131\u2013Labeled Metuximab Injection Combined with Chemoembolization for Unresectable Hepatocellular Carcinoma: Interim Safety and Survival Data from 110 Patients"],"prefix":"10.1177","volume":"25","author":[{"given":"Lu","family":"Wu","sequence":"first","affiliation":[{"name":"Second Military Medical University","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ye-Fa","family":"Yang","sequence":"additional","affiliation":[{"name":"Second Military Medical University","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nai-Jian","family":"Ge","sequence":"additional","affiliation":[{"name":"Second Military Medical University","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shu-Qun","family":"Shen","sequence":"additional","affiliation":[{"name":"Second Military Medical University","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Liang","sequence":"additional","affiliation":[{"name":"Second Military Medical University","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Wang","sequence":"additional","affiliation":[{"name":"Second Military Medical University","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei-Ping","family":"Zhou","sequence":"additional","affiliation":[{"name":"Second Military Medical University","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feng","family":"Shen","sequence":"additional","affiliation":[{"name":"Second Military Medical University","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meng-Chao","family":"Wu","sequence":"additional","affiliation":[{"name":"Second Military Medical University","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2010,12,1]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.3322\/canjclin.55.2.74"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199903113401001"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199603143341104"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.04.009"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2004.045203"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.20426"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)08649-X"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(08)70285-7"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0708857"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2004.05.048"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2005.02.033"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.21811"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2005.12.034"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.4161\/cbt.5.3.2431"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0070-2153(03)54015-7"},{"key":"e_1_3_3_17_2","article-title":"HAb18G\/CD147, it's agonist and application. 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