{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T21:53:03Z","timestamp":1790200383651,"version":"4.1.0"},"reference-count":23,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2013,11,1]],"date-time":"2013-11-01T00:00:00Z","timestamp":1383264000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2013,11,1]],"date-time":"2013-11-01T00:00:00Z","timestamp":1383264000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer Biotherapy and Radiopharmaceuticals"],"published-print":{"date-parts":[[2013,11]]},"abstract":"<jats:p>\n                    <jats:sup>131<\/jats:sup>\n                    I is widely used for therapy in the clinic and\n                    <jats:sup>125<\/jats:sup>\n                    I and\n                    <jats:sup>131<\/jats:sup>\n                    I, and increasingly\n                    <jats:sup>211<\/jats:sup>\n                    At, are often used in experimental studies. It is important to know the biodistribution and dosimetry for these radionuclides to determine potential risk organs when using radiopharmaceuticals containing these radionuclides. The purpose of this study was to investigate the biodistribution of\n                    <jats:sup>125<\/jats:sup>\n                    I\n                    <jats:sup>\u2212<\/jats:sup>\n                    ,\n                    <jats:sup>131<\/jats:sup>\n                    I\n                    <jats:sup>\u2212<\/jats:sup>\n                    , and free\n                    <jats:sup>211<\/jats:sup>\n                    At in rats and to determine absorbed doses to various organs and tissues. Male Sprague Dawley rats were injected simultaneously with 0.1\u20130.3\u2009MBq\n                    <jats:sup>125<\/jats:sup>\n                    I\n                    <jats:sup>\u2212<\/jats:sup>\n                    and 0.1\u20130.3\u2009MBq\n                    <jats:sup>131<\/jats:sup>\n                    I\n                    <jats:sup>\u2212<\/jats:sup>\n                    , or 0.05\u20130.2\u2009MBq\n                    <jats:sup>211<\/jats:sup>\n                    At and sacrificed 1 hour to 7 days after injection. The activities and activity concentrations in organs and tissues were determined and mean absorbed doses were calculated. The biodistribution of\n                    <jats:sup>125<\/jats:sup>\n                    I\n                    <jats:sup>\u2212<\/jats:sup>\n                    was similar to that of\n                    <jats:sup>131<\/jats:sup>\n                    I\n                    <jats:sup>\u2212<\/jats:sup>\n                    but the biodistribution of free\n                    <jats:sup>211<\/jats:sup>\n                    At was different compared to\n                    <jats:sup>125<\/jats:sup>\n                    I\n                    <jats:sup>\u2212<\/jats:sup>\n                    and\n                    <jats:sup>131<\/jats:sup>\n                    I\n                    <jats:sup>\u2212<\/jats:sup>\n                    . The activity concentration of radioiodine was higher compared with\n                    <jats:sup>211<\/jats:sup>\n                    At in the thyroid and lower in all extrathyroidal tissues. The mean absorbed dose per unit injected activity was highest to the thyroid.\n                    <jats:sup>131<\/jats:sup>\n                    I gave the highest absorbed dose to the thyroid, and\n                    <jats:sup>211<\/jats:sup>\n                    At gave the highest absorbed dose to all other tissues studied.\n                  <\/jats:p>","DOI":"10.1089\/cbr.2013.1483","type":"journal-article","created":{"date-parts":[[2013,6,22]],"date-time":"2013-06-22T08:26:16Z","timestamp":1371889576000},"page":"657-664","source":"Crossref","is-referenced-by-count":57,"title":["Biodistribution and Dosimetry of Free\n                    <sup>211<\/sup>\n                    At,\n                    <sup>125<\/sup>\n                    I\n                    <sup>\u2212<\/sup>\n                    and\n                    <sup>131<\/sup>\n                    I\n                    <sup>\u2212<\/sup>\n                    in Rats"],"prefix":"10.1177","volume":"28","author":[{"given":"Johan","family":"Spetz","sequence":"first","affiliation":[{"name":"Sahlgrenska Academy at the University of Gothenburg","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nils","family":"Rudqvist","sequence":"additional","affiliation":[{"name":"Sahlgrenska Academy at the University of Gothenburg","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Forssell-Aronsson","sequence":"additional","affiliation":[{"name":"Sahlgrenska Academy at the University of Gothenburg","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2013,11,1]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1210\/er.2001-0029"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.26.8.483"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0969-8051(00)00179-7"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1103\/PhysRev.58.672"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0020-708X(82)90155-7"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0883-2889(86)90273-X"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-662-05868-8_5"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0167-8140(88)90057-6"},{"key":"e_1_3_3_10_2","first-page":"3514","article-title":"Comparative tissue distribution in mice of the alpha-emitter 211At and 131I as labels of a monoclonal antibody and F(ab\u2032)2 fragment","volume":"50","author":"Garg PK","year":"1990","unstructured":"Garg PK, , Harrison CL, , Zalutsky MR. 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