{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T03:20:02Z","timestamp":1788405602186,"version":"build-2803163510"},"reference-count":40,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer Biotherapy and Radiopharmaceuticals"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>\n                      Prostate-specific membrane antigen (PSMA) has emerged as a promising target for developing radionuclide therapy (RNT) in prostate cancer; however, accumulation of PSMA-RNT in salivary glands can result in irreversible xerostomia. Methods to prevent PSMA-RNT-related xerostomia could be clinically useful; however, little is known about PSMA expression in salivary glands of preclinical animal models. Using [\n                      <jats:sup>18<\/jats:sup>\n                      F]DCFPyL autoradiography\/biodistribution, PSMA expression levels were determined in salivary glands of various preclinical monkey and rodent species and compared with humans.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      Binding affinities (K\n                      <jats:sub>d<\/jats:sub>\n                      ) and PSMA levels (B\n                      <jats:sub>max<\/jats:sub>\n                      ) were determined by\n                      <jats:italic toggle=\"yes\">in vitro<\/jats:italic>\n                      [\n                      <jats:sup>18<\/jats:sup>\n                      F]DCFPyL autoradiography studies.\n                      <jats:italic toggle=\"yes\">In vivo<\/jats:italic>\n                      rodent tissue uptakes (%ID\/g) were determined from [\n                      <jats:sup>18<\/jats:sup>\n                      F]DCFPyL biodistributions.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      [\n                      <jats:sup>18<\/jats:sup>\n                      F]DCFPyL exhibited low nanomolar K\n                      <jats:sub>d<\/jats:sub>\n                      for submandibular gland (SMG) PSMA across all the species. PSMA levels in human SMG (B\n                      <jats:sub>max<\/jats:sub>\n                      \u2009=\u200960.91\u2009nM) were approximately two-fold lower compared with baboon SMG but were two- to three-fold higher than SMG PSMA levels of cynomolgus and rhesus. Rodents had the lowest SMG PSMA levels, with the mouse being 10-fold higher than the rat.\n                      <jats:italic toggle=\"yes\">In vivo<\/jats:italic>\n                      rodent biodistribution studies confirmed these results.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>SMG of monkeys exhibited comparable PSMA expression to human SMG whereas rodents were lower. However, the results suggest that mice are relatively a better small animal preclinical model than rats for PSMA salivary gland studies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/cbr.2019.3079","type":"journal-article","created":{"date-parts":[[2020,2,19]],"date-time":"2020-02-19T17:10:06Z","timestamp":1582132206000},"page":"284-291","source":"Crossref","is-referenced-by-count":20,"title":["Comparison of Prostate-Specific Membrane Antigen Expression Levels in Human Salivary Glands to Non-Human Primates and Rodents"],"prefix":"10.1177","volume":"35","author":[{"given":"Jyoti","family":"Roy","sequence":"first","affiliation":[{"name":"Molecular Imaging Program, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Blake M.","family":"Warner","sequence":"additional","affiliation":[{"name":"National Institute of Dental and Craniofacial Surgery, National Institutes of Health, Bethesda, Maryland, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Falguni","family":"Basuli","sequence":"additional","affiliation":[{"name":"Imaging Probe Development Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Rockville, Maryland, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Imaging Probe Development Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Rockville, Maryland, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Wong","sequence":"additional","affiliation":[{"name":"Molecular Imaging Program, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Pranzatelli","sequence":"additional","affiliation":[{"name":"National Institute of Dental and Craniofacial Surgery, National Institutes of Health, Bethesda, Maryland, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anita T.","family":"Ton","sequence":"additional","affiliation":[{"name":"Molecular Imaging Program, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John A.","family":"Chiorini","sequence":"additional","affiliation":[{"name":"National Institute of Dental and Craniofacial Surgery, National Institutes of Health, Bethesda, Maryland, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter L.","family":"Choyke","sequence":"additional","affiliation":[{"name":"Molecular Imaging Program, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank I.","family":"Lin","sequence":"additional","affiliation":[{"name":"Molecular Imaging Program, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elaine M.","family":"Jagoda","sequence":"additional","affiliation":[{"name":"Molecular Imaging Program, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2020,5,13]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0502101102"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(98)00278-7"},{"key":"e_1_3_4_4_2","first-page":"2256","article-title":"Prostate specific membrane antigen expression in prostatic intraepithelial neoplasia and adenocarcinoma - A study of 184 cases","volume":"82","author":"Bostwick DG","year":"1998","unstructured":"Bostwick DG, , Pacelli A, , Blute M, et al. 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