{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T17:04:57Z","timestamp":1777482297265,"version":"3.51.4"},"reference-count":42,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer Biotherapy and Radiopharmaceuticals"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>Nanocapsules play a role in the targeted delivery of chemotherapy drugs. However, the traditional technology for preparation of nanocapsules is relatively complex with poor controllability, leading to large differences batch to batch. This study aimed to evaluate the quality of drugs-loaded nanocapsules (Drugs-NCs) fabricated by coaxial capillary microfluidic device, and inhibitory effect on malignant tumors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>\n                      In this study, oxaliplatin, irinotecan, and 5-fluorouracil were selected as chemotherapy drugs, and Drugs-NCs were prepared by coaxial glass capillary microfluidic device. Next, transmission electron microscope was utilized to characterize surface morphology and particle size distribution of Drugs-NCs. Then, high performance liquid chromatography was used to determine the drug loading and encapsulation efficiency. Dialysis method was performed to measure the drug release of Drugs-NCs\n                      <jats:italic toggle=\"yes\">in vitro<\/jats:italic>\n                      . To study the effects of Drugs + NCs on tumor growth\n                      <jats:italic toggle=\"yes\">in vivo<\/jats:italic>\n                      , BALB\/c (nu\/nu) nude mice were used\n                      <jats:italic toggle=\"yes\">in vivo<\/jats:italic>\n                      experiments.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The Drugs-NCs were spherical and uniform in size (103.4\u2009nm). Besides, the encapsulation efficiencies of oxaliplatin, irinotecan, and 5-fluorouracil were 97.0%, 95.7%, and 15.6%, respectively. Moreover, drugs encapsulated in the nanocapsules released less and was pH-dependent, with more rapid release being observed at pH 5.5 group compared with pH 7.4 group. MTT assay and\n                      <jats:italic toggle=\"yes\">in vivo<\/jats:italic>\n                      experiments indicated the inhibitory effect of Drugs-NCs on malignant tumors.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The prepared nanocapsules had potential tumor targeting. Furthermore, coaxial capillary microfluidic device could be used as a promising microfluidic technology to fabricate multiple Drug-NCs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/cbr.2019.3412","type":"journal-article","created":{"date-parts":[[2020,3,20]],"date-time":"2020-03-20T15:41:57Z","timestamp":1584718917000},"page":"570-580","source":"Crossref","is-referenced-by-count":5,"title":["Preparation of Biodegradable Polymeric Nanocapsules for Treatment of Malignant Tumor Using Coaxial Capillary Microfluidic Device"],"prefix":"10.1177","volume":"35","author":[{"given":"Yi","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Pharmacy, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, PR China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bingren","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, PR China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiong","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, PR China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianzhang","family":"Wu","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, PR China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bailiang","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, PR China."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2020,10,13]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrd2591"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2017.05.003"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s13346-014-0206-y"},{"key":"e_1_3_4_5_2","first-page":"423","article-title":"Nanonization: A novel approach for enhancement of bioavailability of poorly soluble drugs","volume":"453","author":"Prakash S","year":"2013","unstructured":"Prakash S, , Vidyadhara S, , Sasidhar RLC, et al. Nanonization: A novel approach for enhancement of bioavailability of poorly soluble drugs. Int J Pharm, 2013; 453:423.","journal-title":"Int J Pharm"},{"key":"e_1_3_4_6_2","first-page":"2180","article-title":"Enhanced efficacy of paclitaxel-loaded hyaluronic acid functional emulsion in the treatment of ovarian cancer","volume":"27","author":"Sun XF","year":"2018","unstructured":"Sun XF, , Yang SW, , Yang S, et al. Enhanced efficacy of paclitaxel-loaded hyaluronic acid functional emulsion in the treatment of ovarian cancer. Chin J New Drugs, 2018; 27:2180.","journal-title":"Chin J New Drugs"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2015.10.019"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.14701\/ahbps.2019.23.2.200"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1159\/000361031"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1080\/17425255.2019.1637417"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.7314\/APJCP.2013.14.8.4801"},{"key":"e_1_3_4_12_2","first-page":"527","article-title":"Multiple layer-by-layer lipid-polymer hybrid nanoparticles for improved FOLFIRINOX chemotherapy in pancreatic tumor models","volume":"12","author":"Li F","year":"2016","unstructured":"Li F, , Zhao X, , Wang H, et al. Multiple layer-by-layer lipid-polymer hybrid nanoparticles for improved FOLFIRINOX chemotherapy in pancreatic tumor models. Adv Funct Mater, 2016; 12:527.","journal-title":"Adv Funct Mater"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11095-019-2621-8"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2015.10.022"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.5b07075"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00396-015-3767-5"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.28651"},{"key":"e_1_3_4_18_2","first-page":"198","article-title":"Preparation and characterization of eugenol nanocapsules by self-assembly method","volume":"39","author":"Zhang L","year":"2018","unstructured":"Zhang L, , Zhang J, , Lingyan MA, et al. Preparation and characterization of eugenol nanocapsules by self-assembly method. Food Sci, 2018; 39:198.","journal-title":"Food Sci"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.3390\/molecules22111892"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10404-014-1415-x"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1109164"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1109164"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ces.2015.06.025"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201405408"},{"key":"e_1_3_4_25_2","first-page":"283","article-title":"Development and characterization of nanoparticles of glibenclamide by solvent displacement method","volume":"67","author":"Dora CP","year":"2010","unstructured":"Dora CP, , Singh SK, , Kumar S, et al. Development and characterization of nanoparticles of glibenclamide by solvent displacement method. Acta Pol Pharm, 2010; 67:283.","journal-title":"Acta Pol Pharm"},{"key":"e_1_3_4_26_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11164-017-2879-6"},{"key":"e_1_3_4_27_2","first-page":"1090","article-title":"Recent progress in targeted drug delivery nanosystems for pancreatic cancer treatment","volume":"53","author":"Li MR","year":"2018","unstructured":"Li MR, , Li T, , Mo R. Recent progress in targeted drug delivery nanosystems for pancreatic cancer treatment. Acta Pharm Sin B, 2018; 53:1090.","journal-title":"Acta Pharm Sin B"},{"key":"e_1_3_4_28_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.7b01026"},{"key":"e_1_3_4_29_2","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201570093"},{"key":"e_1_3_4_30_2","doi-asserted-by":"publisher","DOI":"10.1021\/ma100653u"},{"key":"e_1_3_4_31_2","doi-asserted-by":"publisher","DOI":"10.1039\/C8RA06659K"},{"key":"e_1_3_4_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2009.09.036"},{"key":"e_1_3_4_33_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1234139"},{"key":"e_1_3_4_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2015.10.022"},{"key":"e_1_3_4_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.indcrop.2015.11.082"},{"key":"e_1_3_4_36_2","doi-asserted-by":"publisher","DOI":"10.2174\/1381612821666150531165059"},{"key":"e_1_3_4_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2016.05.044"},{"key":"e_1_3_4_38_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-med-040210-162544"},{"key":"e_1_3_4_39_2","doi-asserted-by":"publisher","DOI":"10.1615\/CritRevTherDrugCarrierSyst.2017017845"},{"key":"e_1_3_4_40_2","article-title":"Synthesis and characterization of chitosan-coated magnetite nanoparticles and their application in curcumin drug delivery","volume":"7","author":"Pham XN","year":"2017","unstructured":"Pham XN, , Nguyen TP, , Pham TN, et al. Synthesis and characterization of chitosan-coated magnetite nanoparticles and their application in curcumin drug delivery. Adv Nat Sci Nanosci Nanotechnol, 2017; 7:045010.","journal-title":"Adv Nat Sci Nanosci Nanotechnol"},{"key":"e_1_3_4_41_2","first-page":"3525","article-title":"Polymer-based drug delivery systems for cancer treatment","volume":"54","author":"Guo X","year":"2016","unstructured":"Guo X, , Wang L, , Wei X, et al. Polymer-based drug delivery systems for cancer treatment. Crit Rev Ther Drug Carrier Syst, 2016; 54:3525.","journal-title":"Crit Rev Ther Drug Carrier Syst"},{"key":"e_1_3_4_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2015.12.025"},{"key":"e_1_3_4_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nano.2015.12.226"}],"container-title":["Cancer Biotherapy and Radiopharmaceuticals"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/cbr.2019.3412","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/cbr.2019.3412","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/cbr.2019.3412","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T14:15:35Z","timestamp":1777385735000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/cbr.2019.3412"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10]]},"references-count":42,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2020,10]]}},"alternative-id":["10.1089\/cbr.2019.3412"],"URL":"https:\/\/doi.org\/10.1089\/cbr.2019.3412","relation":{},"ISSN":["1084-9785","1557-8852"],"issn-type":[{"value":"1084-9785","type":"print"},{"value":"1557-8852","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10]]}}}