{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T17:06:10Z","timestamp":1777482370653,"version":"3.51.4"},"reference-count":39,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer Biotherapy and Radiopharmaceuticals"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>The aim of the study was to perform PET imaging and radiotherapy with a novel neurotensin derivative for neurotensin receptor 1 (NTSR-1)-positive tumors in an animal model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>\n                      A di-DOTA analog of NT(6\u201313) with three unnatural amino acids was synthesized and radiolabeled with either\n                      <jats:sup>64<\/jats:sup>\n                      Cu or\n                      <jats:sup>68<\/jats:sup>\n                      Ga and tested for serum stability and tumor imaging in mice bearing NTSR-1-positive PC3, and HT29 xenografts. A dose\u2013response therapy study was performed with 18.5, 37, and 74 kBq of\n                      <jats:sup>225<\/jats:sup>\n                      Ac-di-DOTA-\u03b1,\u025b\u2212Lys-NT(6\u201313).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      <jats:sup>68<\/jats:sup>\n                      Ga-di-DOTA-\u03b1,\u025b\u2212Lys-NT(6\u201313) was &gt;99% stable in serum for 48\u2009h, had an IC\n                      <jats:sub>50<\/jats:sub>\n                      of 5\u2009nM using\n                      <jats:sup>125<\/jats:sup>\n                      I labeled NT(8\u201313) for binding to HT-29 cells, and high uptake in tumor models expressing NTSR-1.\n                      <jats:sup>68<\/jats:sup>\n                      Ga-di-DOTA-\u03b1,\u025b\u2212Lys-NT(6\u201313) had an average %ID\/g (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u20094) at 2\u2009h of 4.0 for tumor, 0.5 for blood, 12.0 for kidney, and &lt;1 for other tissues, resulting in a favorable T\/B of 8. Mean survivals of tumor-bearing mice treated with 18.5 or 37 kBq of\n                      <jats:sup>225<\/jats:sup>\n                      Ac-di-DOTA-\u03b1,\u025b\u2212Lys-NT(6\u201313) were 81 and 93 d, respectively, versus 53 d for controls. Whole-body toxicity was seen for the 74 kBq dose.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>\n                      Based on the results of the animal model, di-DOTA-\u03b1,\u025b\u2212Lys-NT(6\u201313) is a useful imaging agent for NTSR-1-positive tumors when radiolabeled with\n                      <jats:sup>68<\/jats:sup>\n                      Ga, and when radiolabeled with\n                      <jats:sup>225<\/jats:sup>\n                      Ac, a potent therapeutic agent.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/cbr.2020.3926","type":"journal-article","created":{"date-parts":[[2020,8,21]],"date-time":"2020-08-21T15:41:34Z","timestamp":1598024494000},"page":"651-661","source":"Crossref","is-referenced-by-count":4,"title":["Preclinical PET Imaging of NTSR-1-Positive Tumors with\n                    <sup>64<\/sup>\n                    Cu- and\n                    <sup>68<\/sup>\n                    Ga-DOTA-Neurotensin Analogs and Therapy with an\n                    <sup>225<\/sup>\n                    Ac-DOTA-Neurotensin Analog"],"prefix":"10.1177","volume":"36","author":[{"given":"Daneng","family":"Li","sequence":"first","affiliation":[{"name":"Department of Medical Oncology, City of Hope National Medical Center, Duarte, California, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Megan","family":"Minnix","sequence":"additional","affiliation":[{"name":"Deparment of Molecular Imaging and Therapy, Beckman Research Institute of City of Hope, Duarte, California, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebecca","family":"Allen","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, City of Hope National Medical Center, Duarte, California, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James","family":"Bading","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, City of Hope National Medical Center, Duarte, California, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junie","family":"Chea","sequence":"additional","affiliation":[{"name":"Radiopharmacy, Beckman Research Institute of the City of Hope, Duarte, California, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patty","family":"Wong","sequence":"additional","affiliation":[{"name":"Deparment of Molecular Imaging and Therapy, Beckman Research Institute of City of Hope, Duarte, California, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicole","family":"Bowles","sequence":"additional","affiliation":[{"name":"Radiopharmacy, Beckman Research Institute of the City of Hope, Duarte, California, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erasmus","family":"Poku","sequence":"additional","affiliation":[{"name":"Radiopharmacy, Beckman Research Institute of the City of Hope, Duarte, California, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John E.","family":"Shively","sequence":"additional","affiliation":[{"name":"Deparment of Molecular Imaging and Therapy, Beckman Research Institute of City of Hope, Duarte, California, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2021,10,13]]},"reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1259\/bjr.20189004"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1259\/bjr.20170893"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.116.185587"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.116.186361"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1188\/18.CJON.565-568"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.semnuclmed.2015.09.005"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1089\/cbr.2007.0435"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.2174\/1874471012666190201164132"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.2147\/OTT.S97584"},{"key":"e_1_3_5_11_2","doi-asserted-by":"publisher","DOI":"10.1259\/bjr.20180308"},{"key":"e_1_3_5_12_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-09-1252"},{"key":"e_1_3_5_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.peptides.2008.04.014"},{"key":"e_1_3_5_14_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.42.4.546"},{"key":"e_1_3_5_15_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-06-0450"},{"key":"e_1_3_5_16_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-10-0659"},{"key":"e_1_3_5_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.23710"},{"key":"e_1_3_5_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-6147(99)01357-7"},{"key":"e_1_3_5_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/cmdc.201500468"},{"key":"e_1_3_5_20_2","doi-asserted-by":"publisher","DOI":"10.1021\/jm030081k"},{"key":"e_1_3_5_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nucmedbio.2015.07.010"},{"key":"e_1_3_5_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0969-8051(00)00190-6"},{"key":"e_1_3_5_23_2","doi-asserted-by":"publisher","DOI":"10.1021\/bc900151z"},{"key":"e_1_3_5_24_2","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.115.170530"},{"key":"e_1_3_5_25_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.8b00175"},{"key":"e_1_3_5_26_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1834523100"},{"key":"e_1_3_5_27_2","doi-asserted-by":"publisher","DOI":"10.1080\/07391102.2012.736776"},{"key":"e_1_3_5_28_2","doi-asserted-by":"publisher","DOI":"10.1021\/ml1000728"},{"key":"e_1_3_5_29_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.molpharmaceut.9b00283"},{"key":"e_1_3_5_30_2","doi-asserted-by":"publisher","DOI":"10.1177\/1536012117711369"},{"key":"e_1_3_5_31_2","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.114.137489"},{"key":"e_1_3_5_32_2","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.116.185140"},{"key":"e_1_3_5_33_2","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.117.193847"},{"key":"e_1_3_5_34_2","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.115.171371"},{"key":"e_1_3_5_35_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2019.37.15_suppl.TPS3152"},{"key":"e_1_3_5_36_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-003-1189-y"},{"key":"e_1_3_5_37_2","doi-asserted-by":"publisher","DOI":"10.1021\/bc200078p"},{"key":"e_1_3_5_38_2","doi-asserted-by":"publisher","DOI":"10.2337\/db18-1009"},{"key":"e_1_3_5_39_2","doi-asserted-by":"publisher","DOI":"10.1039\/C4DT02983F"},{"key":"e_1_3_5_40_2","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.114.138347"}],"container-title":["Cancer Biotherapy and Radiopharmaceuticals"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/cbr.2020.3926","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/cbr.2020.3926","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/cbr.2020.3926","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T14:15:57Z","timestamp":1777385757000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/cbr.2020.3926"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10]]},"references-count":39,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2021,10]]}},"alternative-id":["10.1089\/cbr.2020.3926"],"URL":"https:\/\/doi.org\/10.1089\/cbr.2020.3926","relation":{},"ISSN":["1084-9785","1557-8852"],"issn-type":[{"value":"1084-9785","type":"print"},{"value":"1557-8852","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10]]}}}