{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T16:36:45Z","timestamp":1789576605041,"version":"build-2803163510"},"reference-count":32,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer Biotherapy and Radiopharmaceuticals"],"published-print":{"date-parts":[[2026,5,1]]},"abstract":"<jats:p>\n                    Ovarian cancer (OC) is known to be the most malignant gynecologic cancers.\n                    <jats:italic toggle=\"yes\">Wnt2B<\/jats:italic>\n                    , a member of the Wnt family, plays a critical role in tumor development. However, the effect of\n                    <jats:italic toggle=\"yes\">Wnt2B<\/jats:italic>\n                    on the occurrence and development of OC remains largely uncharacterized. In this study, immunohistochemistry assay indicated that\n                    <jats:italic toggle=\"yes\">Wnt2B<\/jats:italic>\n                    was increased in our study cohort (OC). In addition, the expression of\n                    <jats:italic toggle=\"yes\">Wnt2B<\/jats:italic>\n                    was positively correlated with TNM stages and metastasis of OC patients.\n                    <jats:italic toggle=\"yes\">Wnt2B<\/jats:italic>\n                    markedly mediated the regulation of OC proliferation, invasion, and angiogenesis. Moreover,\n                    <jats:italic toggle=\"yes\">Wnt2B<\/jats:italic>\n                    knockdown inactivated the Wnt\/\u03b2-catenin signaling pathway. More importantly, the Wnt\/\u03b2-catenin signaling pathway activator LiCl reversed the effect of\n                    <jats:italic toggle=\"yes\">Wnt2B<\/jats:italic>\n                    knockdown on OC cell proliferation, angiogenesis, and invasion. Our data indicated that\n                    <jats:italic toggle=\"yes\">Wnt2B<\/jats:italic>\n                    silencing could inhibit the proliferation, invasion, and angiogenesis of OC cells through downregulating the activity of Wnt\/\u03b2-catenin pathway.\n                  <\/jats:p>","DOI":"10.1089\/cbr.2021.0004","type":"journal-article","created":{"date-parts":[[2022,2,7]],"date-time":"2022-02-07T02:51:55Z","timestamp":1644202315000},"page":"348-353","source":"Crossref","is-referenced-by-count":7,"title":["Downregulated\n                    <i>Wnt2B<\/i>\n                    Expression Suppresses Proliferation, Invasion, and Angiogenesis of Ovarian Cancer Cells Through Inhibiting the Wnt\/\u03b2-Catenin Signaling Pathway"],"prefix":"10.1177","volume":"41","author":[{"given":"Shengsheng","family":"Yu","sequence":"first","affiliation":[{"name":"Department of Obstetrics, The Affiliated Huaian No. 1 People's Hospital of Nanjing Medical University, Huai'an, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing","family":"Pen","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, The Affiliated Huaian No. 1 People's Hospital of Nanjing Medical University, Huai'an, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haoyu","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, The Affiliated Huaian No. 1 People's Hospital of Nanjing Medical University, Huai'an, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiong","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, The Affiliated Huaian No. 1 People's Hospital of Nanjing Medical University, Huai'an, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3157-0244","authenticated-orcid":false,"given":"Haidong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, The Affiliated Huaian No. 1 People's Hospital of Nanjing Medical University, Huai'an, China."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,5,28]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21551"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2003.02.153"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2016.61"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.cellbio.20.010403.113126"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2013.09.034"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-16-1115"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2012.290"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2016.15"},{"key":"e_1_3_4_10_2","first-page":"1103","article-title":"WNT2B: Comparative integromics and clinical applications (Review)","volume":"16","author":"Katoh M","year":"2005","unstructured":"Katoh M. WNT2B: Comparative integromics and clinical applications (Review). Int J Mol Med, 2005; 16:1103.","journal-title":"Int J Mol Med"},{"key":"e_1_3_4_11_2","first-page":"4531","article-title":"Expression of Gli1 and Wnt2B correlates with progression and clinical outcome of pancreatic cancer","volume":"7","author":"Jiang H","year":"2014","unstructured":"Jiang H, , Li F, , He C, et al. Expression of Gli1 and Wnt2B correlates with progression and clinical outcome of pancreatic cancer. Int J Clin Exp Pathol, 2014; 7:4531.","journal-title":"Int J Clin Exp Pathol"},{"key":"e_1_3_4_12_2","first-page":"2753","article-title":"miR-577 suppresses cell proliferation and epithelial-mesenchymal transition by regulating the WNT2B mediated Wnt\/\u03b2-catenin pathway in non-small cell lung cancer","volume":"18","author":"Wang B","year":"2018","unstructured":"Wang B, , Sun L, , Li J, et al. miR-577 suppresses cell proliferation and epithelial-mesenchymal transition by regulating the WNT2B mediated Wnt\/\u03b2-catenin pathway in non-small cell lung cancer. Mol Med Rep, 2018; 18:2753.","journal-title":"Mol Med Rep"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.3349\/ymj.2019.60.12.1146"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/IGC.0b013e3182540284"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-019-1549-6"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.28942"},{"key":"e_1_3_4_17_2","first-page":"94","article-title":"Effect and mechanism of miR-217 on drug resistance, invasion and metastasis of ovarian cancer cells through a regulatory axis of CUL4B gene silencing\/inhibited Wnt\/\u03b2-catenin signaling pathway activation","volume":"25","author":"Liu HR","year":"2021","unstructured":"Liu HR, , Zhao J. Effect and mechanism of miR-217 on drug resistance, invasion and metastasis of ovarian cancer cells through a regulatory axis of CUL4B gene silencing\/inhibited Wnt\/\u03b2-catenin signaling pathway activation. Eur Rev Med Pharmacol Sci, 2021; 25:94.","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-20-2041"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2020.10.031"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-020-01244-z"},{"key":"e_1_3_4_21_2","first-page":"22034521994756","article-title":"LiCl promotes recovery of radiation-induced oral mucositis and dysgeusia","author":"Zhu J","year":"2021","unstructured":"Zhu J, , Zhang H, , Li J, et al. LiCl promotes recovery of radiation-induced oral mucositis and dysgeusia. J Dent Res, 2021:22034521994756.","journal-title":"J Dent Res"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00223-021-00833-4"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1111\/cas.12555"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2018.08.079"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.2147\/CMAR.S225911"},{"key":"e_1_3_4_26_2","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.12923"},{"key":"e_1_3_4_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2018.03.008"},{"key":"e_1_3_4_28_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-17-0749"},{"key":"e_1_3_4_29_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-018-0972-4"},{"key":"e_1_3_4_30_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-017-3298-1"},{"key":"e_1_3_4_31_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13046-018-0973-2"},{"key":"e_1_3_4_32_2","first-page":"393","article-title":"SFRP1 inhibited the epithelial ovarian cancer through inhibiting Wnt\/\u03b2-catenin signaling","volume":"66","author":"Zhang H","year":"2019","unstructured":"Zhang H, , Sun D, , Qiu J, et al. SFRP1 inhibited the epithelial ovarian cancer through inhibiting Wnt\/\u03b2-catenin signaling. 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