{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T16:43:09Z","timestamp":1777480989649,"version":"3.51.4"},"reference-count":27,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer Biotherapy and Radiopharmaceuticals"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>\n                      This study evaluated the effect of an increase in the time interval between hepatic intra-arterial injection of\n                      <jats:sup>99m<\/jats:sup>\n                      Tc-macroaggregated albumin (MAA) and hepatic artery perfusion scintigraphy (HAPS) on the lung shunt fraction (LSF) and perfused volume (PV) calculations in the treatment planning of selective internal radiation therapy (SIRT).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      The authors enrolled 51 HAPS sessions from 40 patients diagnosed with primary or metastatic liver malignancy. All patients underwent scan at the first and fourth hour after hepatic arterial injection of\n                      <jats:sup>99m<\/jats:sup>\n                      Tc-MAA. Based on single-photon emission computed tomography images, LSF values were measured from each patient's first and fourth hour images. PV1 and PV4 were also calculated based on three-dimensional images using 5% and 10% cutoff threshold values and compared with each other.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The authors found that the median of LSF4 was statistically significantly higher than LSF1 (3.05 vs. 4.14,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009\u2264\u20090.01). There was no statistically significant difference between PV1 and PV4 on the 10% (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.72) thresholds.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>LSF values can be overestimated in case of delayed HAPS, potentially leading to treatment cancellation due to incorrectly high results in patients who could benefit from SIRT. Threshold-based PV values do not significantly change over time; nevertheless, keeping the short interval time would be safer.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/cbr.2023.0149","type":"journal-article","created":{"date-parts":[[2024,1,24]],"date-time":"2024-01-24T11:31:47Z","timestamp":1706095907000},"page":"330-336","source":"Crossref","is-referenced-by-count":1,"title":["Influence of Early Versus Delayed Hepatic Artery Perfusion Scan on\n                    <sup>90<\/sup>\n                    Y Selective Internal Radiation Therapy Planning"],"prefix":"10.1177","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4431-8358","authenticated-orcid":false,"given":"Bilal","family":"Kovan","sequence":"first","affiliation":[{"name":"Department of Nuclear Medicine, Istanbul Faculty of Medicine, Istanbul University, Fatih\/\u0130stanbul, Turkey."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8270-9480","authenticated-orcid":false,"given":"Dilara","family":"Denizmen","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Istanbul Faculty of Medicine, Istanbul University, Fatih\/\u0130stanbul, Turkey."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4745-3501","authenticated-orcid":false,"given":"Caner","family":"Civan","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Istanbul Faculty of Medicine, Istanbul University, Fatih\/\u0130stanbul, Turkey."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1158-5361","authenticated-orcid":false,"given":"Serkan","family":"Kuyumcu","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Istanbul Faculty of Medicine, Istanbul University, Fatih\/\u0130stanbul, Turkey."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3786-8052","authenticated-orcid":false,"given":"Emine Goknur","family":"Isik","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Istanbul Faculty of Medicine, Istanbul University, Fatih\/\u0130stanbul, Turkey."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6945-2003","authenticated-orcid":false,"given":"Duygu","family":"Has Simsek","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Istanbul Faculty of Medicine, Istanbul University, Fatih\/\u0130stanbul, Turkey."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0360-358X","authenticated-orcid":false,"given":"Zeynep Gozde","family":"Ozkan","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Istanbul Faculty of Medicine, Istanbul University, Fatih\/\u0130stanbul, Turkey."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8851-1109","authenticated-orcid":false,"given":"Arzu","family":"Poyanli","sequence":"additional","affiliation":[{"name":"Department of Radiology, Istanbul Faculty of Medicine, Istanbul University, Fatih\/\u0130stanbul, Turkey."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6815-6384","authenticated-orcid":false,"given":"Bayram","family":"Demir","sequence":"additional","affiliation":[{"name":"Department of Physics, Faculty of Science, Istanbul University, Fatih\/\u0130stanbul, Turkey."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1267-2379","authenticated-orcid":false,"given":"Yasemin","family":"Sanli","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Istanbul Faculty of Medicine, Istanbul University, Fatih\/\u0130stanbul, 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Measuring lung shunting in hepatocellular carcinoma with intrahepatic-arterial technetium-99m macroaggregated albumin. 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