{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T16:43:17Z","timestamp":1777480997318,"version":"3.51.4"},"reference-count":24,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer Biotherapy and Radiopharmaceuticals"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>\n                      The aim of this study was to evaluate the potential role of [\n                      <jats:sup>18<\/jats:sup>\n                      F]FDG positron emission tomography\/computed tomography (PET\/CT) in the characterization of thymic epithelial tumors (TETs).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>\n                      A total of 73 patients who underwent preoperative [\n                      <jats:sup>18<\/jats:sup>\n                      F]FDG PET\/CT were included in this study. Visual total score (VTS), maximum standard uptake values (SUV\n                      <jats:sub>max<\/jats:sub>\n                      ), metabolic tumor volume (MTV), total lesion glycolysis (TLG), and heterogeneity index (HI) parameters were analyzed to investigate the prediction of histopathologic grade and advanced stage.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The cohort included 26 patients with low-grade thymoma (LGT), 36 patients with high-grade thymoma (HGT), and 11 patients with thymic carcinoma (TC). Ninety-one percent of TC had VTS &gt;2, whereas 31% of LGT and 75% of HGT had VTS &gt;2. SUV\n                      <jats:sub>max<\/jats:sub>\n                      , MTV, and TLG were statistically significantly higher in the TC group than in both thymoma and HGT. Using the cutoff value of 7.25 for SUV\n                      <jats:sub>max<\/jats:sub>\n                      , TC was differentiated from thymomas with 91% sensitivity and 74% specificity. TC had significantly lower HI values than thymomas. HI parameters showed good diagnostic ability to differentiate TC from thymoma and TC from HGT. SUV\n                      <jats:sub>max<\/jats:sub>\n                      , MTV, and TLG were significantly higher in advanced-stage disease than in early-stage disease.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>\n                      Visual and quantitative parameters can reliably predict both advanced disease and the grade of primary tumor in TETs. Therefore, as a promising metabolic imaging method, [\n                      <jats:sup>18<\/jats:sup>\n                      F]FDG PET\/CT makes important contributions to preoperative evaluation in routine clinical practice.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/cbr.2023.0192","type":"journal-article","created":{"date-parts":[[2024,3,14]],"date-time":"2024-03-14T16:53:40Z","timestamp":1710435220000},"page":"373-380","source":"Crossref","is-referenced-by-count":1,"title":["The Role of [\n                    <sup>18<\/sup>\n                    F]FDG PET\/CT in the Characterization of Thymic Epithelial Tumors at Initial Stage"],"prefix":"10.1177","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4745-3501","authenticated-orcid":false,"given":"Caner","family":"Civan","sequence":"first","affiliation":[{"name":"Department of Nuclear Medicine and Istanbul Faculty of Medicine, Istanbul UniversityIstanbul, T\u00fcrkiye."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0360-358X","authenticated-orcid":false,"given":"Zeynep Gozde","family":"Ozkan","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine and Istanbul Faculty of Medicine, Istanbul UniversityIstanbul, T\u00fcrkiye."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2157-4778","authenticated-orcid":false,"given":"Berker","family":"Ozkan","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Istanbul Faculty of Medicine, Istanbul UniversityIstanbul, T\u00fcrkiye."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3786-8052","authenticated-orcid":false,"given":"Emine Goknur","family":"Isik","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine and Istanbul Faculty of Medicine, Istanbul UniversityIstanbul, T\u00fcrkiye."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8153-0107","authenticated-orcid":false,"given":"Eren","family":"Erdogdu","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Istanbul Faculty of Medicine, Istanbul UniversityIstanbul, T\u00fcrkiye."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6945-2003","authenticated-orcid":false,"given":"Duygu","family":"Has Simsek","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine and Istanbul Faculty of Medicine, Istanbul UniversityIstanbul, T\u00fcrkiye."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5755-7449","authenticated-orcid":false,"given":"Salih","family":"Duman","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Istanbul Faculty of Medicine, Istanbul UniversityIstanbul, 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