{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T16:44:01Z","timestamp":1777481041512,"version":"3.51.4"},"reference-count":38,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer Biotherapy and Radiopharmaceuticals"],"published-print":{"date-parts":[[2025,1]]},"abstract":"\n Background:<\/jats:title>\n Adult acute leukemia most commonly manifests as acute myeloid leukemia (AML), a highly heterogeneous malignant tumor of the blood system. The application of genetic diagnostic technology is currently prevalent in numerous clinical sectors. According to recent research, the presence of specific gene mutations or rearrangements in leukemia cells is the primary cause of the disease. As different types of leukemia are caused by atypical mutated genes, testing for these mutations or rearrangements can help diagnose leukemia and identify the disease\u2019s molecular targets for treatment.<\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n \n Using the search fields \u201c\n WT1<\/jats:italic>\n ,\u201d \u201c\n DNMT3A<\/jats:italic>\n ,\u201d \u201cAcute myeloid leukemia,\u201d and \u201csurvival,\u201d the CBM, Cochrane Library, Scopus, EMBASE, and PUBMED databases were separately reviewed. The methodology for evaluating the risk of bias developed by the Cochrane Collaboration was used in conjunction with a methodical evaluation of pertinent literature. Excluded studies with the following characteristics: (1) incomplete and repetitive publications, (2) unable to retrieve or convert data, (3) non-English or Chinese articles.\n <\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n This analysis included 13 studies covering a total of 3478 subjects. The frequency of Wilms\u2019 Tumor 1 (\n WT1<\/jats:italic>\n ) mutations is 6.7%\u201335.73%, and the frequency of\n DNMT3A<\/jats:italic>\n mutations is 12.06%\u201351.1%. The remission rate of patients with\n WT1<\/jats:italic>\n mutations was less than that of patients without\n WT1<\/jats:italic>\n mutations (OR = 0.22; 95% confidence interval [CI]: 0.14, 0.36;\n p<\/jats:italic>\n < 0.00001;\n I<\/jats:italic>\n 2<\/jats:sup>\n = 55%). The\n DNMT3A<\/jats:italic>\n mutation has no statistical significance for the prognosis of AML (OR = 1.21; 95% CI: 0.93, 1.58;\n p<\/jats:italic>\n = 0.16;\n I<\/jats:italic>\n 2<\/jats:sup>\n = 80%). After removing one study, the heterogeneity of the indicator (mitigation rate) among other studies of\n DNMT3A<\/jats:italic>\n mutation was dramatically reduced (OR = 0.63; 95% CI: 0.43, 0.93;\n p<\/jats:italic>\n = 0.02;\n I<\/jats:italic>\n 2<\/jats:sup>\n = 0%).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions:<\/jats:title>\n \n Our meta-analysis shows that\n WT1<\/jats:italic>\n mutations hurt the remission rate of AML. Moreover, the impact of\n DNMT3A<\/jats:italic>\n mutations on AML needs to be treated with caution. Gene diagnosis is critical for the prognosis and clinical management of AML.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1089\/cbr.2024.0093","type":"journal-article","created":{"date-parts":[[2024,8,29]],"date-time":"2024-08-29T14:20:15Z","timestamp":1724941215000},"page":"22-30","source":"Crossref","is-referenced-by-count":0,"title":["WT1<\/i>\n and\n DNMT3A<\/i>\n Mutations in Prognostic Significance of Acute Myeloid Leukemia: A Meta-Analysis"],"prefix":"10.1177","volume":"40","author":[{"given":"Shiyue","family":"Ma","sequence":"first","affiliation":[{"name":"Department of Clinical Laboratory, Affiliated Hospital of Guilin Medical University, Guangxi Zhuang Autonomous Region, Guilin, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lingjian","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Rehabilitative Medicine, Affiliated Hospital of Guilin Medical University, Guangxi Zhuang Autonomous Region, Guilin, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Affiliated Hospital of Guilin Medical University, Guangxi Zhuang Autonomous Region, Guilin, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chaoli","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Affiliated Hospital of Guilin Medical University, Guangxi Zhuang Autonomous Region, Guilin, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xue","family":"Pu","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Affiliated Hospital of Guilin Medical University, Guangxi Zhuang Autonomous Region, Guilin, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-0520-978X","authenticated-orcid":false,"given":"Jun","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Affiliated Hospital of Guilin Medical University, Guangxi Zhuang Autonomous Region, Guilin, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ninhong","family":"Niu","sequence":"additional","affiliation":[{"name":"Department of Medical Administration, Nanxishan Hospital of Guangxi Zhuang Autonomous Region, Guangxi Zhuang Autonomous Region, Guilin, China."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,1,30]]},"reference":[{"issue":"3","key":"e_1_3_5_2_2","first-page":"38","article-title":"Acute myeloid leukemia: A review","volume":"103","author":"Pelcovits A","year":"2020","unstructured":"Pelcovits A, , Niroula R. Acute myeloid leukemia: A review. R I Med J (2013), 2020; 103(3):38\u201340.","journal-title":"R I Med J (2013)"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hoc.2017.08.006"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2012.43.4738"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.186536"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s13311-020-00835-4"},{"issue":"5","key":"e_1_3_5_7_2","first-page":"675","article-title":"The WT1 gene\u2013its role in tumourigenesis and prospects for immunotherapeutic advances","volume":"28","author":"Lindstedt I","year":"2014","unstructured":"Lindstedt I, , Lindgren MA, , Andersson E, et al. The WT1 gene\u2013its role in tumourigenesis and prospects for immunotherapeutic advances. 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WT1 mutation in 470 adult patients with acute myeloid leukemia: Stability during disease evolution and implication of its incorporation into a survival scoring system. Blood, The Journal of the American Society of Hematology, 2010; 115(25):5222\u20135231.","journal-title":"Blood, The Journal of the American Society of Hematology"},{"key":"e_1_3_5_32_2","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2014.243"},{"issue":"23","key":"e_1_3_5_33_2","first-page":"5951","article-title":"Clinical relevance of Wilms tumor 1 gene mutations in childhood acute myeloid leukemia","volume":"113","author":"Hollink IHIM","year":"2009","unstructured":"Hollink IHIM, , van den Heuvel-Eibrink MM, , Zimmermann M, et al. Clinical relevance of Wilms tumor 1 gene mutations in childhood acute myeloid leukemia. 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