{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T16:44:47Z","timestamp":1777481087417,"version":"3.51.4"},"reference-count":30,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer Biotherapy and Radiopharmaceuticals"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Circular RNA (circRNA) plays a regulatory role in the malignancy of papillary thyroid cancer (PTC). However, the role of a novel circRNA, hsa_circ_0118578, in PTC is not yet fully understood. This report focuses on unveiling hsa_circ_0118578\u2019s effect on PTC cell malignancy and reveals its mechanism in PTC progression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      Levels of hsa_circ_0118578 in PTC were assessed by quantitative real-time polymerase chain reaction (qRT-PCR). The functional roles of hsa_circ_0118578 in PTC cell malignancy were evaluated through Transwell, 5-ethynyl-2\n                      <jats:bold>\u2032<\/jats:bold>\n                      -deoxyuridine (EdU), and wound healing assays. A xenograft model in nude mice was used to examine the effects of hsa_circ_0118578\u2019s\n                      <jats:italic toggle=\"yes\">in vivo<\/jats:italic>\n                      . The interaction between eukaryotic translation initiation factor 4A3 (EIF4A3) and hsa_circ_0118578 was confirmed using RNA-binding protein immunoprecipitation, qRT-PCR, and Western blotting.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Hsa_circ_0118578 with high expression in PTC tissues was associated with higher tumor node metastasis stage, lymph node metastasis, as well as poor differentiation. Cell functional assays demonstrated that silencing hsa_circ_0118578 inhibited PTC cell proliferation, invasion, and migration. In the xenograft assay, tumorigenicity of PTC cells\n                      <jats:italic toggle=\"yes\">in vivo<\/jats:italic>\n                      was reduced following hsa_circ_0118578 suppression. Additionally, EIF4A3, as an RNA-binding protein, was shown to interact with hsa_circ_0118578 to stabilize its expression in PTC cells.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Upregulated hsa_circ_0118578 in PTC interacts with EIF4A3 to exert oncogenic effects by enhancing hsa_circ_0118578 stability, contributing to PTC development. These findings shed light on the oncogenic role of hsa_circ_0118578 in PTC and suggest it as a potential therapeutic target.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/cbr.2024.0133","type":"journal-article","created":{"date-parts":[[2024,12,17]],"date-time":"2024-12-17T19:04:27Z","timestamp":1734462267000},"page":"285-292","source":"Crossref","is-referenced-by-count":2,"title":["EIF4A3-Induced hsa_circ_0118578 Expression Enhances the Tumorigenesis of Papillary Thyroid Cancer"],"prefix":"10.1177","volume":"40","author":[{"given":"Chan","family":"Li","sequence":"first","affiliation":[{"name":"Department of Tradition Chinese Medicine, Wuhan Third Hospital (Tongren Hospital of Wuhan University), Wuhan, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ping","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Tradition Chinese Medicine, Wuhan Third Hospital (Tongren Hospital of Wuhan University), Wuhan, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meng","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Tradition Chinese Medicine, Wuhan Third Hospital (Tongren Hospital of Wuhan University), Wuhan, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kun","family":"Lv","sequence":"additional","affiliation":[{"name":"Department of Tradition Chinese Medicine, Wuhan Third Hospital (Tongren Hospital of Wuhan University), Wuhan, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-3885-1601","authenticated-orcid":false,"given":"Zewei","family":"Cong","sequence":"additional","affiliation":[{"name":"Department of Tradition Chinese Medicine, Wuhan Third Hospital (Tongren Hospital of Wuhan University), Wuhan, China."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,5,12]]},"reference":[{"key":"e_1_3_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecl.2018.10.002"},{"key":"e_1_3_6_3_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.959840"},{"key":"e_1_3_6_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12325-020-01391-1"},{"key":"e_1_3_6_5_2","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2020.00102"},{"key":"e_1_3_6_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00432-022-04541-w"},{"key":"e_1_3_6_7_2","doi-asserted-by":"publisher","DOI":"10.1042\/EBC20200032"},{"key":"e_1_3_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2023.110455"},{"key":"e_1_3_6_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/543183a"},{"key":"e_1_3_6_10_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-020-01286-3"},{"key":"e_1_3_6_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcla.24688"},{"key":"e_1_3_6_12_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13046-018-0936-7"},{"key":"e_1_3_6_13_2","doi-asserted-by":"publisher","DOI":"10.1042\/BST20150163"},{"key":"e_1_3_6_14_2","doi-asserted-by":"publisher","DOI":"10.1158\/1541-7786.MCR-22-0984"},{"key":"e_1_3_6_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/ctm2.1102"},{"key":"e_1_3_6_16_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13046-022-02368-4"},{"key":"e_1_3_6_17_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-020-01183-9"},{"key":"e_1_3_6_18_2","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/noaa214"},{"key":"e_1_3_6_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41420-022-00892-y"},{"issue":"12","key":"e_1_3_6_20_2","first-page":"5868","article-title":"EIF4A3 induced circGRIK2 promotes the malignancy of glioma by regulating the miR-1303\/HOXA10 axis","volume":"13","author":"Li F","year":"2023","unstructured":"Li F, , Song W, , Wu L, et al. EIF4A3 induced circGRIK2 promotes the malignancy of glioma by regulating the miR-1303\/HOXA10 axis. Am J Cancer Res, 2023; 13(12):5868\u20135886.","journal-title":"Am J Cancer Res"},{"key":"e_1_3_6_21_2","doi-asserted-by":"publisher","DOI":"10.3390\/genes14071314"},{"key":"e_1_3_6_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcla.23819"},{"key":"e_1_3_6_23_2","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.644011"},{"key":"e_1_3_6_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41420-021-00798-1"},{"key":"e_1_3_6_25_2","doi-asserted-by":"publisher","DOI":"10.2103\/7\/gs-21-481"},{"key":"e_1_3_6_26_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1009798"},{"key":"e_1_3_6_27_2","doi-asserted-by":"publisher","DOI":"10.1261\/rna.070565.119"},{"key":"e_1_3_6_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2017.07.045"},{"key":"e_1_3_6_29_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-21-2988"},{"issue":"2","key":"e_1_3_6_30_2","first-page":"602","article-title":"EIF4A3 induced circABCA5 promotes the gastric cancer progression by SPI1 mediated IL6\/JAK2\/STAT3 signaling","volume":"13","author":"Hou G","year":"2023","unstructured":"Hou G, , Zuo H, , Shi J, et al. EIF4A3 induced circABCA5 promotes the gastric cancer progression by SPI1 mediated IL6\/JAK2\/STAT3 signaling. 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