{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T16:44:46Z","timestamp":1777481086803,"version":"3.51.4"},"reference-count":22,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer Biotherapy and Radiopharmaceuticals"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>\n                      To evaluate the use of yttrium-90 (\n                      <jats:sup>90<\/jats:sup>\n                      Y) dosimetry in predicting treatment outcomes when used following transarterial radioembolization with SIR-Spheres\u00ae (Resin\n                      <jats:sup>90<\/jats:sup>\n                      Y) in patients with hepatic tumors.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>\n                      This single institution retrospective analysis included 100 patients with hepatocellular carcinoma, colorectal carcinoma or other liver metastases who underwent transarterial radioembolization with resin\n                      <jats:sup>90<\/jats:sup>\n                      Y and had imaging follow-up within one year of treatment. Mean tumor dose and mean dose to nontumor was calculated using voxel-based dosimetry software. Descriptive statistics were reported and methods of analyses included simple and multivariable linear regression, contingency table analyses, Kaplan\u2212Meier estimation, and Cox proportional hazards models.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Of 100 patients included, 65 demonstrated tumor shrinkage following transarterial radioembolization. Of these, 20 (30.8%) had hepatocellular carcinoma, 22 (33.8%) had colorectal carcinoma, and 23 (35.4%) had other types of metastases. There was an association between tumor shrinkage and mean tumor dose (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = 0.0285) and mean dose to nontumor (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = 0.0028) in hepatocellular carcinoma patients, but not colorectal carcinoma, or the other subgroup. For all 100 patients, time to death and mean tumor dose was associated only in the other subgroup (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = 0.0260), but not in the hepatocellular or colorectal carcinoma groups. Time to death and mean dose to nontumor was associated in hepatocellular carcinoma patients (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = 0.0421), but not the colorectal carcinoma or other subgroup.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Voxel-based dosimetry assessment is a tool that may be utilized to assist in predicting treatment outcomes in responders to transarterial radioembolization.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/cbr.2024.0194","type":"journal-article","created":{"date-parts":[[2025,1,29]],"date-time":"2025-01-29T15:21:16Z","timestamp":1738164076000},"page":"244-253","source":"Crossref","is-referenced-by-count":0,"title":["Dosimetry Assessment in Predicting Treatment Outcomes Following Yttrium-90 Transarterial Radioembolization of Hepatic Tumors"],"prefix":"10.1177","volume":"40","author":[{"given":"Christina","family":"Ward","sequence":"first","affiliation":[{"name":"Department of Interventional Radiology, University of Kansas Medical Center, Kansas City, Kansas, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-9811-4641","authenticated-orcid":false,"given":"Sandon","family":"Scott","sequence":"additional","affiliation":[{"name":"Department of Interventional Radiology, University of Kansas Medical Center, Kansas City, Kansas, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William","family":"Wesson","sequence":"additional","affiliation":[{"name":"Department of Interventional Radiology, University of Kansas Medical Center, Kansas City, Kansas, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jared","family":"Mazurek","sequence":"additional","affiliation":[{"name":"Department of Interventional Radiology, University of Kansas Medical Center, Kansas City, Kansas, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ian","family":"Kozlowski","sequence":"additional","affiliation":[{"name":"Department of Interventional Radiology, University of Kansas Medical Center, Kansas City, Kansas, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregg","family":"Werner","sequence":"additional","affiliation":[{"name":"Department of Interventional Radiology, University of Kansas Medical Center, Kansas City, Kansas, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arshan","family":"Dehbozorgi","sequence":"additional","affiliation":[{"name":"Department of Interventional Radiology, University of Kansas Medical Center, Kansas City, Kansas, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Milind","family":"Phadnis","sequence":"additional","affiliation":[{"name":"Department of Biostatistics &amp; Data Science, University of Kansas School Medical Center, Kansas City, Kansas, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carissa","family":"Walter","sequence":"additional","affiliation":[{"name":"Department of Interventional Radiology, University of Kansas Medical Center, Kansas City, Kansas, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aaron","family":"Rohr","sequence":"additional","affiliation":[{"name":"Department of Interventional Radiology, University of Kansas Medical Center, Kansas City, Kansas, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zachary","family":"Collins","sequence":"additional","affiliation":[{"name":"Department of Interventional Radiology, University of Kansas Medical Center, Kansas City, Kansas, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,5,12]]},"reference":[{"key":"e_1_3_6_2_2","unstructured":"About SIRT. 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