{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T11:42:23Z","timestamp":1790854943311,"version":"4.1.0"},"reference-count":36,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2010,7,14]],"date-time":"2010-07-14T00:00:00Z","timestamp":1279065600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2010,7,14]],"date-time":"2010-07-14T00:00:00Z","timestamp":1279065600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cellular Reprogramming"],"published-print":{"date-parts":[[2010,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Induced pluripotent Huntington's disease monkey stem cells (rHD-iPSCs) were established by the overexpression of rhesus macaque transcription factors (Oct4, Sox2, and Klf4) in transgenic Huntington's monkey skin fibroblasts. The rHD-iPSCs were pluripotent and capable of differentiating into neuronal cell types\n                    <jats:italic toggle=\"yes\">in vitro<\/jats:italic>\n                    and developed teratoma in immune compromised mice. We also demonstrated the upregulation of endogenous Oct4 and Sox2 after successful reprogramming to pluripotency in rHD-iPSCs, which was not expressed in skin fibroblasts. rHD-iPSCs also developed cellular features comparable to Huntington's disease (HD), including the accumulation of mutant huntingtin (htt) aggregate and the formation of intranuclear inclusions (NIs) paralleling neural differentiation\n                    <jats:italic toggle=\"yes\">in vitro<\/jats:italic>\n                    . Induced pluripotent stem cells from transgenic HD monkeys open a new era of nonhuman primate modeling of human diseases. rHD-iPSCs that develop key HD cellular features and parallel neural differentiation can be a powerful platform for investigating the developmental impact on HD pathogenesis and developing new therapies, which can be evaluated in HD monkeys from whom the rHD-iPSCs were derived.\n                  <\/jats:p>","DOI":"10.1089\/cell.2010.0019","type":"journal-article","created":{"date-parts":[[2010,7,14]],"date-time":"2010-07-14T20:58:39Z","timestamp":1279141119000},"page":"509-517","source":"Crossref","is-referenced-by-count":54,"title":["Reprogramming Huntington Monkey Skin Cells into Pluripotent Stem Cells"],"prefix":"10.1177","volume":"12","author":[{"given":"Anthony W.S.","family":"Chan","sequence":"first","affiliation":[{"name":"Emory University School of Medicine","place":["Georgia"]},{"name":"Emory University School of Medicine","place":["Georgia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei-Hsun","family":"Cheng","sequence":"additional","affiliation":[{"name":"Emory University School of Medicine","place":["Georgia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam","family":"Neumann","sequence":"additional","affiliation":[{"name":"Emory University School of Medicine","place":["Georgia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-Jing","family":"Yang","sequence":"additional","affiliation":[{"name":"Emory University School of Medicine","place":["Georgia"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2010,7,14]]},"reference":[{"key":"e_1_3_3_2_1","doi-asserted-by":"publisher","DOI":"10.1042\/bst0260471"},{"key":"e_1_3_3_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature06357"},{"key":"e_1_3_3_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7827-2-39"},{"key":"e_1_3_3_5_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI41801"},{"key":"e_1_3_3_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/mp.54.6.409"},{"key":"e_1_3_3_7_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1158799"},{"key":"e_1_3_3_8_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.19-07-02522.1999"},{"key":"e_1_3_3_9_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1152092"},{"key":"e_1_3_3_10_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI40553"},{"key":"e_1_3_3_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-59745-536-7_8"},{"key":"e_1_3_3_12_1","doi-asserted-by":"publisher","DOI":"10.1089\/scd.2007.0026"},{"key":"e_1_3_3_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2121-11-12"},{"key":"e_1_3_3_14_1","doi-asserted-by":"publisher","DOI":"10.1634\/stemcells.2007-1081"},{"key":"e_1_3_3_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1326-1-19"},{"key":"e_1_3_3_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2008.10.014"},{"key":"e_1_3_3_17_1","first-page":"237","article-title":"Therapeutic perspectives for the treatment of Huntington's disease: treating the whole body","volume":"23","author":"Martin B.","year":"2008","unstructured":"Martin B., , Golden E., , Keselman A. et al. 2008. 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