{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T17:13:56Z","timestamp":1790097236019,"version":"4.0.1"},"reference-count":27,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2023,9,28]],"date-time":"2023-09-28T00:00:00Z","timestamp":1695859200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Childhood Obesity"],"published-print":{"date-parts":[[2023,10,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Performance of vibration-controlled transient elastography (VCTE) is inadequately validated in pediatric nonalcoholic fatty liver disease (NAFLD). We aimed to assess the technical performance of VCTE in pediatric NAFLD and define the agreement between VCTE and reference standards of imaging and\/or biopsy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This prospective study recruited participants with known or suspected NAFLD who underwent a research VCTE examination (FibroScan Mini 430). Ten valid VCTE liver stiffness measurements (kPa) and controlled attenuation parameter (CAP) (dB\/m) measurements were obtained for each participant. Available clinically acquired MR elastography and magnetic resonance imaging proton density fat fraction (PDFF), liver ultrasound shear wave elastography, and biopsy served as references standards.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Eighty-four consecutive participants were included (55 males, mean age 15.0\u2009\u00b1\u20093.5 years, mean BMI 36.6\u2009\u00b1\u20099.4\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      ). VCTE examinations were complete in 80\/83 participants. 37\/83 participants were examined with an XL probe. There was no significant correlation between CAP and PDFF [\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u200916;\n                      <jats:italic toggle=\"yes\">r<\/jats:italic>\n                      \u2009=\u20090.17 (95% confidence interval [CI]: \u22120.34 to 0.61),\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.5] or between VCTE liver stiffness and MR elastography stiffness [\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u200927;\n                      <jats:italic toggle=\"yes\">r<\/jats:italic>\n                      \u2009=\u20090.31 (95% CI: \u22120.07 to 0.62),\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.10]. For prediction of any fibrosis stage \u22651 on biopsy (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u20099\/15 participants), VCTE median liver stiffness &gt;5.1 kPA had an area under receiver operating characteristic curve of 0.52 (95% CI: 0.26\u20130.78) with a sensitivity of 88.9% and specificity of 16.6% (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&gt;\u20090.99).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Complete VCTE examinations could be obtained in most pediatric patients with NAFLD. Neither VCTE liver stiffness nor CAP correlated well with measures of liver fat or stiffness by established imaging modalities and biopsy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/chi.2022.0136","type":"journal-article","created":{"date-parts":[[2022,10,21]],"date-time":"2022-10-21T11:48:47Z","timestamp":1666352927000},"page":"461-469","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":22,"title":["Clinical Performance of Transient Elastography With Comparison to Quantitative Magnetic Resonance Imaging, Ultrasound, and Biopsy in Children and Adolescents With Known or Suspected Fatty Liver Disease"],"prefix":"10.1177","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8772-4770","authenticated-orcid":false,"given":"Vinicius","family":"P.V. 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Trout","sequence":"additional","affiliation":[{"name":"Department of Radiology and Hepatology and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA."},{"name":"Department of Radiology and University of Cincinnati College of Medicine, Cincinnati, OH, USA."},{"name":"Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morgan","family":"Dewit","sequence":"additional","affiliation":[{"name":"Department of Radiology and Hepatology and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marialena","family":"Mouzaki","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA."},{"name":"Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Catalina","family":"Arce-Clachar","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA."},{"name":"Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristin","family":"S. Bramlage","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA."},{"name":"Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"R. Dillman","sequence":"additional","affiliation":[{"name":"Department of Radiology and Hepatology and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA."},{"name":"Department of Radiology and University of Cincinnati College of Medicine, Cincinnati, OH, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stavra","family":"A. 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