{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T03:56:25Z","timestamp":1773287785043,"version":"3.50.1"},"reference-count":88,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Computational Biology"],"published-print":{"date-parts":[[2025,1,1]]},"abstract":"<jats:p>In this study, we develop a comprehensive model to investigate the intricate relationship between the bone remodeling process, tumor growth, and bone diseases such as multiple myeloma. By analyzing different scenarios within the Basic Multicellular Unit, we uncover the dynamic interplay between remodeling and tumor progression. The model developed developed in the paper are based on the well accepted Komarova\u2019s and Ayati\u2019s models for the bone remodeling process, then these models were modified to include the effects of the tumor growth. Our in silico experiments yield results consistent with existing literature, providing valuable insights into the complex dynamics at play. This research aims to improve the clinical management of bone diseases and metastasis, paving the way for targeted interventions and personalized treatment strategies to enhance the quality of life for affected individuals.<\/jats:p>","DOI":"10.1089\/cmb.2023.0390","type":"journal-article","created":{"date-parts":[[2024,12,26]],"date-time":"2024-12-26T10:52:32Z","timestamp":1735210352000},"page":"104-124","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Is Tumor Growth Influenced by the Bone Remodeling Process?"],"prefix":"10.1177","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7821-5234","authenticated-orcid":false,"given":"Juan Felipe","family":"S\u00e1nchez","sequence":"first","affiliation":[{"name":"Biotechnology Institute, Universidad Nacional de Colombia, Bogota, Colombia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salah","family":"Ramtani","sequence":"additional","affiliation":[{"name":"Laboratoire CSPBAT, equipe LBPS, CNRS (UMR 7244), Universit e Sorbonne Paris Nord, Villetaneuse, France."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdelkader","family":"Boucetta","sequence":"additional","affiliation":[{"name":"Laboratoire CSPBAT, equipe LBPS, CNRS (UMR 7244), Universit e Sorbonne Paris Nord, Villetaneuse, France."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco Antonio","family":"Velasco","sequence":"additional","affiliation":[{"name":"Universidad Distrital Francisco Jos\u00e9 de Caldas, Bogota, Colombia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan Jairo","family":"Vaca-Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Escuela de Pregrado - Direccion Acad\u00e9mica, Universidad Nacional de Colombia, La Paz, Colombia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos A.","family":"Duque-Daza","sequence":"additional","affiliation":[{"name":"Biotechnology Institute, Universidad Nacional de Colombia, Bogota, Colombia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diego A.","family":"Garz\u00f3n-Alvarado","sequence":"additional","affiliation":[{"name":"Biotechnology Institute, Universidad Nacional de Colombia, Bogota, Colombia."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,1,9]]},"reference":[{"key":"e_1_3_5_2_1","unstructured":"Abd Rahman N. Apoptosis and cell cycle mechanisms of ampelopsin e on triple negative breast cancer cells. 2017."},{"key":"e_1_3_5_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20020280"},{"key":"e_1_3_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gastrohep.2008.10.011"},{"key":"e_1_3_5_5_1","unstructured":"Arias Moreno AJ. Modelo computacional para simulaci\u00f3n del proceso de osteog\u00e9nesis y la curaci\u00f3n \u00f3sea despu\u00e9s de la fractura. PhD thesis 2011."},{"key":"e_1_3_5_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.23203"},{"key":"e_1_3_5_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/1745-6150-5-28"},{"key":"e_1_3_5_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrclinonc.2015.204"},{"key":"e_1_3_5_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-29182-6_4"},{"key":"e_1_3_5_10_1","doi-asserted-by":"publisher","DOI":"10.1109\/JBHI.2015.2453437"},{"key":"e_1_3_5_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.12258"},{"key":"e_1_3_5_12_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-05-2630"},{"key":"e_1_3_5_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbi.2015.07.011"},{"key":"e_1_3_5_14_1","article-title":"The bone ecosystem facilitates multiple myeloma relapse and the evolution of heterogeneous proteasome inhibitor resistant disease","author":"Bishop RT","year":"2023","unstructured":"Bishop RT, , Miller AK, , Froid M, et al. The bone ecosystem facilitates multiple myeloma relapse and the evolution of heterogeneous proteasome inhibitor resistant disease. bioRxiv, 2023; doi: 10.1101\/2022.11.13.516335","journal-title":"bioRxiv"},{"issue":"10","key":"e_1_3_5_15_1","first-page":"717","article-title":"Mod\u00e9lisation du remodelage osseux","volume":"1","author":"Bonfoh N","year":"2008","unstructured":"Bonfoh N, , Bilasse M, , Lipinski P. Mod\u00e9lisation du remodelage osseux. Revue de, 2008; 1(10):717\u2013726.","journal-title":"Revue de"},{"key":"e_1_3_5_16_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1331360100"},{"key":"e_1_3_5_17_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.21.0807"},{"issue":"3","key":"e_1_3_5_18_1","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1002\/cncr.11144","article-title":"Bone cancer pain","volume":"97","author":"Clohisy DR","year":"2003","unstructured":"Clohisy DR, , Mantyh PW. Bone cancer pain. Cancer: Interdiscipl Internat J Ameri Can Society, 2003; 97(S3):866\u2013873.","journal-title":"Cancer: Interdiscipl Internat J Ameri Can Society"},{"key":"e_1_3_5_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtbi.2015.11.024"},{"key":"e_1_3_5_20_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-06-0931"},{"key":"e_1_3_5_21_1","doi-asserted-by":"publisher","DOI":"10.1053\/ctrv.2000.0210"},{"key":"e_1_3_5_22_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111663200"},{"key":"e_1_3_5_23_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-03-0576"},{"key":"e_1_3_5_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.12378"},{"key":"e_1_3_5_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/cgt.2009.40"},{"key":"e_1_3_5_26_1","unstructured":"Durie DBG. Bone disease 2021. Available from: https:\/\/www.myeloma.org\/bone-disease#:\u223c:text=Focal%20lesions%20are%20early%2C%20abnormal the%20next%2018%2D24%20months"},{"key":"e_1_3_5_27_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pathol-011110-130203"},{"key":"e_1_3_5_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.33588"},{"key":"e_1_3_5_29_1","volume-title":"Global cancer observatory: cancer today","author":"Ferlay J","year":"2018","unstructured":"Ferlay J, , Ervik M, , Lam F, et al. Global cancer observatory: cancer today. International Agency for Research on Cancer: lyon, france; 2018."},{"issue":"8","key":"e_1_3_5_30_1","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1002\/(SICI)1097-0142(19971015)80:8+<1581::AID-CNCR8>3.0.CO;2-N","article-title":"Mechanisms of the development of osteoblastic metastases","volume":"80","author":"Goltzman D","year":"1997","unstructured":"Goltzman D. Mechanisms of the development of osteoblastic metastases. Canc: Interdisci Inter J American Can Soci, 1997; 80(S8):1581\u20131587.","journal-title":"Canc: Interdisci Inter J American Can Soci"},{"key":"e_1_3_5_31_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI118947"},{"key":"e_1_3_5_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1043-2760(00)00256-3"},{"key":"e_1_3_5_33_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1365.035"},{"key":"e_1_3_5_34_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005373-196511000-00015"},{"key":"e_1_3_5_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/74999"},{"key":"e_1_3_5_36_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2020.00165"},{"key":"e_1_3_5_37_1","doi-asserted-by":"publisher","DOI":"10.1148\/rg.317115093"},{"key":"e_1_3_5_38_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M202561200"},{"key":"e_1_3_5_39_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0506517102"},{"key":"e_1_3_5_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1535-6108(03)00132-6"},{"key":"e_1_3_5_41_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1015599831232"},{"key":"e_1_3_5_42_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.25.9820"},{"key":"e_1_3_5_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.03.041"},{"key":"e_1_3_5_44_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1346.052"},{"key":"e_1_3_5_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/S8756-3282(03)00157-1"},{"key":"e_1_3_5_46_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCO.0b013e3282f54cf2"},{"key":"e_1_3_5_47_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22062911"},{"key":"e_1_3_5_48_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0015482"},{"key":"e_1_3_5_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2012.03.021"},{"key":"e_1_3_5_50_1","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-08-0497"},{"key":"e_1_3_5_51_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-06-4130"},{"issue":"3","key":"e_1_3_5_52_1","first-page":"555","article-title":"Functional adaptation of bone as an optimal control problem","volume":"43","author":"Lekszycki T","year":"2005","unstructured":"Lekszycki T. Functional adaptation of bone as an optimal control problem. J Theoretical Applied Mechanics, 2005; 43(3):555\u2013574.","journal-title":"J Theoretical Applied Mechanics"},{"key":"e_1_3_5_53_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10237-015-0705-x"},{"key":"e_1_3_5_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2011.11.002"},{"key":"e_1_3_5_55_1","doi-asserted-by":"publisher","DOI":"10.4081\/oncol.2017.321"},{"key":"e_1_3_5_56_1","doi-asserted-by":"crossref","unstructured":"Maldonado S Borchers S Findeisen R et al. Mathematical modeling and analysis of force induced bone growth. In 2006 International Conference of the IEEE Engineering in Medicine and Biology Society pages 3154\u20133157. IEEE 2006.","DOI":"10.1109\/IEMBS.2006.260532"},{"key":"e_1_3_5_57_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.240560312"},{"key":"e_1_3_5_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.matcom.2006.06.014"},{"key":"e_1_3_5_59_1","doi-asserted-by":"publisher","DOI":"10.5114\/aoms.2019.84732"},{"key":"e_1_3_5_60_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc867"},{"key":"e_1_3_5_61_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers10110398"},{"key":"e_1_3_5_62_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22136865"},{"key":"e_1_3_5_63_1","doi-asserted-by":"publisher","DOI":"10.1111\/fcp.12259"},{"key":"e_1_3_5_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2022.116450"},{"key":"e_1_3_5_65_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar2168"},{"key":"e_1_3_5_66_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-07-1243"},{"key":"e_1_3_5_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2019.04.030"},{"key":"e_1_3_5_68_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.240550303"},{"key":"e_1_3_5_69_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.R109.041087"},{"key":"e_1_3_5_70_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10237-023-01689-3"},{"key":"e_1_3_5_71_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00109-015-1329-4"},{"key":"e_1_3_5_72_1","doi-asserted-by":"publisher","DOI":"10.1038\/psp.2014.12"},{"key":"e_1_3_5_73_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-12-0084"},{"key":"e_1_3_5_74_1","doi-asserted-by":"publisher","DOI":"10.1088\/0031-9155\/55\/12\/001"},{"key":"e_1_3_5_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cct.2006.05.011"},{"key":"e_1_3_5_76_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra030831"},{"key":"e_1_3_5_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2008.04.140"},{"key":"e_1_3_5_78_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1022627421000"},{"key":"e_1_3_5_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2005.03.011"},{"key":"e_1_3_5_80_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2004.00.6908"},{"key":"e_1_3_5_81_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660"},{"key":"e_1_3_5_82_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6604125"},{"key":"e_1_3_5_83_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.289.5484.1504"},{"key":"e_1_3_5_84_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00774-004-0533-z"},{"key":"e_1_3_5_85_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-08-3863"},{"key":"e_1_3_5_86_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-14-2945"},{"key":"e_1_3_5_87_1","doi-asserted-by":"publisher","DOI":"10.1088\/0031-9155\/58\/17\/5851"},{"key":"e_1_3_5_88_1","doi-asserted-by":"publisher","DOI":"10.1002\/psp4.12450"},{"key":"e_1_3_5_89_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI3523"}],"container-title":["Journal of Computational Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/cmb.2023.0390","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/cmb.2023.0390","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/cmb.2023.0390","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T12:13:49Z","timestamp":1773231229000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/cmb.2023.0390"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,1]]},"references-count":88,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1,1]]}},"alternative-id":["10.1089\/cmb.2023.0390"],"URL":"https:\/\/doi.org\/10.1089\/cmb.2023.0390","relation":{},"ISSN":["1066-5277","1557-8666"],"issn-type":[{"value":"1066-5277","type":"print"},{"value":"1557-8666","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,1]]}}}